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Tumor Discovery Mechanism of Buddleja officinalis against ESCC

key components acacetin, linarin, and procyanidin B1 Consent for publication
as ligands. The results showed that linarin had a good
binding ability to AKT1, and its interaction with AKT1 Not applicable.
was more stable than that of acacetin or procyanidin B1. Availability of data
In the current study, we used a network pharmacology
approach to systematically uncover the inhibitory effect of Data used in this work are available from the corresponding
a TCM medicine on ESCC. However, several noteworthy author on reasonable request.
limitations in this study are worth highlighting. For References
example, we did not validate target genes experimentally
to eliminate irrelevant targets. Moreover, experimental 1. Short MW, Burgers KG, Fry VT. Esophageal cancer. Am Fam
validation analysis of the mechanisms was not integrated Physician. 2017;95(1):22-28.
into this study; therefore, further basic or clinical studies 2. Domper Arnal MJ, Ferrandez Arenas A, Lanas Arbeloa A.
are required to validate the molecular mechanisms by Esophageal cancer: Risk factors, screening and endoscopic
which BO inhibits ESCC. treatment in Western and Eastern countries. World J
Gastroenterol. 2015;21(26):7933-7943.
5. Conclusion doi: 10.3748/wjg.v21.i26.7933
Acacetin, linarin, luteolin, butyrospermyl acetate, 3. Huang FL, Yu SJ. Esophageal cancer: Risk factors, genetic
procyanidin B1, and neobyakangelicol are potential active association, and treatment. Asian J Surg. 2018;41(3):210-
components of BO. In addition, AKT1 is a potential 215.
therapeutic target of BO, and its effects on ESCC may be doi: 10.1016/j.asjsur.2016.10.005
mediated by MAPK signaling pathway.
4. Pan Y, Sun Z, Wang W, et al. Automatic detection of
Acknowledgments squamous cell carcinoma metastasis in esophageal lymph
nodes using semantic segmentation. Clin Transl Med.
None. 2020;10(3):e129.

Funding doi: 10.1002/ctm2.129
This research was financially supported by the Henan 5. Hou X, Wen J, Ren Z, Zhang G. Non-coding RNAs: New
biomarkers and therapeutic targets for esophageal cancer.
Province Medical Science and Technology Research Oncotarget. 2017;8(26):43571-43578.
Program Joint Construction Project (NO. LHGJ20210696),
and General Program of Natural Science Foundation of doi: 10.18632/oncotarget.16721
Henan Province (NO. 212300410393). 6. Zhong R, Chen Z, Mo T, Li Z, Zhang P. Potential role of
circPVT1 as a proliferative factor and treatment target in
Conflict of interest esophageal carcinoma. Cancer Cell Int. 2019;19:267.
The authors declare no conflicts of interest. doi: 10.1186/s12935-019-0985-9
Author contributions 7. Cao S, Chen G, Yan L, Li L, Huang X. Contribution
of dysregulated circRNA_100876 to proliferation and
Conceptualization: Zhen-Zhen Yang, Na Gao, Yin-Sen Song metastasis of esophageal squamous cell carcinoma. Onco
Targets Ther. 2018;11:7385-7394.
Formal analysis: Zhen-Zhen Yang, Na Gao
doi: 10.2147/OTT.S177524
Investigation: Zhen-Zhen Yang, Na Gao, Xiao-Lin Zhang
8. Houghton PJ, Mensah AY, Iessa N, Hong LY. Terpenoids in
Writing – original draft: Zhen-Zhen Yang Buddleja: relevance to chemosystematics, chemical ecology
Writing – review & editing: Yin-Sen Song, Xiao-Lin Zhang and biological activity. Phytochemistry. 2003;64(2):385-393.
doi: 10.1016/s0031-9422(03)00264-4
Data visualization: Cheng Chang, Hao-Zhe Zhang
9. Lee YJ, Kang DG, Kim JS, Lee HS. Buddleja officinalis
Data analysis: Tian-Li Fan inhibits high glucose-induced matrix metalloproteinase
All authors have read and agreed to the published version activity in human umbilical vein endothelial cells. Phytother
of the manuscript. Res. 2008;22(12):1655-1659.
doi: 10.1002/ptr.2547
Ethics approval and consent to participate
10. Tai BH, Jung BY, Cuong NM, et al. Total peroxynitrite
Not applicable. scavenging capacity of phenylethanoid and flavonoid

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