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Tumor Discovery MMP-1 as a potential biomarker for gastric cancer

to improve patient prognosis and survival. In addition, the Taicang Science and Technology Bureau
medical imaging and mathematical modeling techniques (TC2019JCYL18), and the Taicang Science and Technology
have been used to diagnose gastric cancer at an early Bureau (TC2018JCYL20).
stage. 58-62 Bioinformatics methods have shown that ITGAX,
CCL14, ADHFE1, and HOXB13 are expressed at significantly Conflict of interest
higher levels in gastric cancer tumor tissues than in adjacent The authors declare that they have no competing interests.
normal tissues. Furthermore, immunohistochemistry was
63
employed to study the low expression of MLL2 in tissue Author contributions
microarrays of 529 cases of human gastric cancer and its Conceptualization: Qing Li, Ke Yi
correlation with early-stage cancer. These genes may serve
64
as gastric cancer marker genes, providing ideas for future Data analysis: Xiaoli Zhu
Formal analysis: Ke Yi
experimental studies, and similar stories abound.
Investigation: Ke Yi
Metastasis is a leading contributor to cancer Methodology: Yan Hu
morbidity and mortality, resulting in approximately 90% Writing – original draft: Ke Yi
of cancer-related deaths. The biochemical events and Writing – review & editing: Xiaoli Zhu, Qing Li
parameters involved in the metastatic process and tumor
microenvironment have been targeted or can be potential Ethics approval and consent to participate
targets for metastasis prevention and inhibition. 65-67 Not applicable.
Epithelial-mesenchymal transition is a process that is
required for the progression of many types of malignant Consent for publication
tumors. 68-72 Matrix metalloproteinases are involved in
various essential functions, including cell regeneration, Not applicable.
programmed cell death, and angiogenesis, as well as Availability of data
normal developmental and pathological processes such
as EMT. MMP-1 is a critical factor in the development The datasets analyzed in the current study are available
73
of several tumors, and several articles have reported that from the corresponding author on reasonable request.
MMP-1 is involved in EMT-associated processes, including
9
hepatocellular carcinoma, head-and-neck cancer, References
74
75
cervical cancer, and colorectal cancer. Furthermore, 1. Rahman R, Asombang AW, Ibdah JA. Characteristics
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increased expression levels of MMP-1 have been observed of gastric cancer in Asia. World J Gastroenterol.
in the tumor cells and tumor-associated stroma of breast 2014;20(16):4483-4490.
cancer individuals with EMT markers present in the doi: 10.3748/wjg.v20.i16.4483
peripheral blood compared to those without EMT markers.
In addition, tumor grade is independently correlated with 2. Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R.
MMP-1 expression in cancer cells, 77,78 suggesting that Gastric cancer: Epidemiology, risk factors, classification,
genomic characteristics and treatment strategies. Int J Mol
MMP-1 plays an essential role in tumor EMT and staging. Sci. 2020;21(11):4012.
5. Conclusion doi: 10.3390/ijms21114012
This study demonstrated that MMP-1 holds promise as a 3. Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H.
specific diagnostic marker for EGC. In addition, it illustrated Gastric cancer. Lancet. 2016;388(10060):2654-2664.
the effects of MMP-1 modulation on the proliferation and doi: 10.1016/s0140-6736(16)30354-3
migration of gastric cancer cells, a finding that has not 4. Yang MD, Lin KC, Lu MC, et al. Contribution of matrix
been reported previously. Therefore, these findings provide metalloproteinases-1 genotypes to gastric cancer
important insights for setting future research directions. susceptibility in Taiwan. BioMedicine (Taipei). 2017;7(2):10.
Acknowledgments doi: 10.1051/bmdcn/2017070203

None. 5. Cui N, Hu M, Khalil RA. Biochemical and biological
attributes of matrix metalloproteinases. Prog Mol Biol Transl
Funding Sci. 2017;147:1-73.

This study was supported by the guiding projects of the doi: 10.1016/bs.pmbts.2017.02.005
Suzhou Science and Technology Bureau (SYSD2019036), 6. Tsai CW, Chang WS, Gong CL, et al. Contribution of

Volume 3 Issue 1 (2024) 7 https://doi.org/10.36922/td.1973