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Tumor Discovery MMP-1 as a potential biomarker for gastric cancer

A

B

Figure 5. Effect of MMP-1 on the migration of gastric cancer cells detected by scratch healing assay: (A) Effect of upregulation of MMP-1 expression on
the migration of gastric cancer cells and (B) effect of downregulation of MMP-1 expression on the migration of gastric cancer cells.
Abbreviations: Ad-MMP-1: MMP-1-overexpression plasmid; NC: Negative control.

A B

Figure 6. Effect of MMP-1 on the expression of epithelial-mesenchymal transition-related proteins in gastric cancer cells, as detected by western blotting:
(A) Western blot detection of related protein expression and (B) grayscale value comparisons of differences in related protein expression levels.
Abbreviations: Ad-MMP-1: MMP-1-overexpression plasmid; NC: Negative control.

that of matched paraneoplastic non-cancerous tissues, The low survival rate of numerous stomach cancer
and its high expression was significantly associated patients is due to the fact that the tumor is often detected
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with lymphatic metastasis as well as TNM staging. in the middle or late stages. 38,39 Timely and comprehensive
An association between polymorphisms in the MMP-1 treatment is crucial for a better prognosis. 40-43 The diagnosis
promoter and the risk of gastric cancer, particularly in of gastrointestinal tumors still relies on invasive upper
conjunction with smoking behavior and Helicobacter gastrointestinal endoscopy. 44,45 However, noninvasive tests
pylori infection, has been reported in Taiwan, potentially and highly specific biomarkers can provide valuable data
useful in the early detection and prevention of gastric for gastric cancer screening and diagnosis. For instance,
cancer. This conclusion was drawn from a survey peripheral blood, 46,47 urine, 48,49 and body fluids such as
4
involving 121 gastric cancer patients and 363 matched saliva, 50,51 gastric lavage, and gastric juices 53,54 can serve as
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healthy volunteers, supported by literature evidence. good sources. Population-based surveillance programs have
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Effective screening methods for early detection can been effective in reducing gastric cancer-related morbidity
facilitate the timely treatment of patients and improve and mortality in several countries. 56,57 Therefore, early
their chances of survival. 34-37 diagnosis strategies are crucial for providing timely treatment

Volume 3 Issue 1 (2024) 6 https://doi.org/10.36922/td.1973