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Tumor Discovery MMP-1 as a potential biomarker for gastric cancer
A B
Figure 1. Results related to whole transcriptome sequencing of early gastric cancer/paracancerous tissues and advanced gastric cancer/paracancerous
tissues: (A) Differentially expressed coding genes in early gastric cancer (EGC) and advanced gastric cancer (AGC); (B) Heatmap of 44 differentially
expressed genes shared by both EGC and AGC.
A
B C
Figure 2. MMP-1 as a potential diagnostic marker for early gastric cancer: (A) A search of TCGA database revealed that high expression of or mutations
in MMP-1 was present in a variety of malignancies, and MMP-1 polymorphisms were found to be associated with gastric cancer in gastric cancer-related
studies; (B) MMP-1 expression in early cancer and paracancerous tissues was detected by fluorescence quantitative PCR. *P < 0.05; (C) Receiver operating
characteristic curve (ROC) analysis was performed using SPSS software.
Abbreviations: AUC: Area under the curve; PCR: Polymerase chain reaction; TGCA: The Cancer Genome Atlas; MMP-1: Matrix metalloproteinase-1.
Volume 3 Issue 1 (2024) 4 https://doi.org/10.36922/td.1973
