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Tumor Discovery Signet ring cell carcinoma of the urinary bladder

to the primary site of origin of a malignant tumor and manuscript have been conducted in accordance with the
2
molecular approaches that could be useful to this goal are Declaration of Helsinki and its later amendments.
not always accessible, 16,17 the application of deep-learning-
based algorithms on whole-slide histological images is a Consent for publication
18
promising tool for identifying the primary site of origin of Informed consent for the publication of data and images
a CUP. was obtained from the next-of-kin as the subject had
4. Conclusion passed away.

Primary SRCC is a variant of adenocarcinoma that rarely Availability of data
develops primarily in the urinary bladder. It may manifest All data generated or analyzed during this study are
as a CUP, as evidenced by the case described here. The included in the submitted article.
prognosis of this carcinoma is typically dismal as it is an
aggressive tumor, and the diagnosis is generally made at an References
advanced stage of the disease. The urinary bladder should 1. Krämer A, Bochtler T, Pauli C, et al. Cancer of unknown
be considered as a site of origin of SRCC when the most primary: ESMO Clinical Practice Guideline for diagnosis,
common sites of origin (i.e., the gastrointestinal tract) have treatment and follow-up. Ann Oncol. 2023;34(3):228-246.
been excluded, even in the absence of an endoluminal mass
and with negative urinary cytology results, as observed in doi: 10.1016/j.annonc.2022.11.013
the case reported here. We believe that our case may have 2. Levi F, Te VC, Erler G, Randimbison L, La Vecchia C.
significant implications in clinical practice. It is imperative Epidemiology of unknown primary tumours. Eur J Cancer.
that clinicians are aware of the possibility of a metastatic 2002;38(13):1810-1812.
SRCC originating from the urinary bladder. doi: 10.1016/s0959-8049(02)00135-1
Acknowledgments 3. Massard C, Loriot Y, Fizazi K. Carcinomas of an unknown
primary origin--diagnosis and treatment. Nat Rev Clin
None. Oncol. 2011;8(12):701-710.

Funding doi: 10.1038/nrclinonc.2011.158
4. Pavlidis N, Fizazi K. Carcinoma of unknown primary
None. (CUP). Crit Rev Oncol Hematol. 2009;69(3):271-278.

Conflict of interest doi: 10.1016/j.critrevonc.2008.09.005
The authors declare that they have no competing interests. 5. Oien KA. Pathologic evaluation of unknown primary
cancer. Semin Oncol. 2009;36(1):8-37.
Author contributions doi: 10.1053/j.seminoncol.2008.10.009
Conceptualization: Emma Rullo, Mara Riminucci, 6. Beauchamp K, Moran B, O’Brien T, et al. Carcinoma of
Alessandro Corsi, Salvatore Minisola unknown primary (CUP): An update for histopathologists.
Formal analysis: Emma Rullo, Piergianni Biondi, Chiara Cancer Metastasis Rev. 2023;42:1189-1200.
Nicolazzo, Walter Gianni, Luciano Colangelo, Mirella doi: 10.1007/s10555-023-10101-6
Cilli, Paola Gazzaniga, Mara Riminucci, Alessandro
Corsi 7. Celik O, Budak S, Ekin G, Akarken I, Ilbey YO. A case
Methodology: Emma Rullo, Chiara Nicolazzo, Paola with primary signet ring cell adenocarcinoma of the
prostate and review of the literature. Arch Ital Urol Androl.
Gazzaniga, Mara Riminucci, Alessandro Corsi 2014;86(2):148-149.
Investigation: Emma Rullo, Chiara Nicolazzo, Paola
Gazzaniga, Mara Riminucci, Alessandro Corsi, doi: 10.4081/aiua.2014.2.148
Salvatore Minisola 8. Lendorf ME, Dohn LH, Dunga BA, Loya AC, Pappot H.
Writing–original draft: Emma Rullo An updated review on primary signet-ring cell carcinoma
Writing–review & editing: Emma Rullo, Mara Riminucci, of the urinary bladder and report of a case. Scand J Urol.
Alessandro Corsi, Salvatore Minisola 2018;52(2):87-93.
doi: 10.1080/21681805.2017.1418020
Ethics approval and consent to participate
9. Benerjee N, Parmar K, Vaiphei K. Primary signet-ring
Ethical approval is not required as this is a case report. All cell carcinoma of the urinary bladder. Autops Case
the clinical and pathologic investigations detailed in the Rep. 2021;11:e2021264.

Volume 3 Issue 4 (2024) 4 doi: 10.36922/td.3736