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Tumor Discovery                                                  RNA-protein complexes deregulated in cancer



               malignancy  via regulation of CD44 v6 expression.  Front   phosphorylation through phase separation and participates
               Oncol. 2022;12:862250.                             in mouse oocyte maturation.  Acta Biochim Biophys Sin
                                                                  (Shanghai). 2021;53(11):1527-1537.
               doi: 10.3389/fonc.2022.862250
            128. Lin Y, Zhong W, Lin Q, et al. SFPQ promotes the proliferation,      doi: 10.1093/abbs/gmab123
               migration and invasion of hepatocellular carcinoma cells   139. Zhan T, Cheng X, Zhu Q, et al. LncRNA LOC105369504
               and is associated with poor prognosis. Am J Cancer Res.   inhibits tumor proliferation and metastasis in colorectal
               2023;13(6):2269-2284.                              cancer by regulating PSPC1. Cell Death Discov. 2023;9(1):89.
            129. Xiao M, Wang F, Chen N, et al. Smad4 sequestered in SFPQ      doi: 10.1038/s41420-023-01384-3
               condensates prevents TGF-β tumor-suppressive signaling.
               Dev Cell. 2024;59(1):48-63.e8.                  140. Mohankumar K, Shrestha R, Safe S. Nuclear receptor 4A1
                                                                  (NR4A1) antagonists target paraspeckle component 1
               doi: 10.1016/j.devcel.2023.11.020                  (PSPC1) in cancer cells. Mol Carcinog. 2022;61(1):73-84.
            130. Ji Q, Zhang L, Liu X, et al. Long noncoding RNA MALAT1      doi: 10.1002/mc.23362
               promotes tumor growth and metastasis in colorectal cancer
               by binding to SFPQ and releasing the oncogene PTBP2 from   141. Zhang H, Su X,  Burley SK, Zheng  XFS. mTOR regulates
               the SFPQ/PTBP2 complex. Br J Cancer. 2014;111:736-748.  aerobic glycolysis through NEAT1 and nuclear paraspeckle-
                                                                  mediated mechanisms in hepatocellular carcinoma.
               doi: 10.1038/bjc.2014.383                          Theranostics. 2022;12:3518-3533.
            131. Klotz-Noack K, Klinger B, Rivera M, et al. SFPQ depletion      doi: 10.7150/thno.72581
               is synthetically lethal with BRAFV600E in colorectal cancer
               cells. Cell Rep. 2020;32(12):108184.            142. Hussein MA, Valinezhad K, Adel E, Munirathinam G.
                                                                  MALAT-1 is a key regulator of epithelial-mesenchymal
               doi: 10.1016/j.celrep.2020.108184                  transition in cancer: A  potential therapeutic target for
            132. Zhang XL, Chen XH, Xu B, et al. K235 acetylation couples   metastasis. Cancers (Basel). 2024;16(1):234.
               with PSPC1 to regulate the m6A demethylation activity of      doi: 10.3390/cancers16010234
               ALKBH5 and tumorigenesis. Nat Commun. 2023;14(1):3815.
                                                               143. Nakagawa S, Ip JY, Shioi G,  et al. Malat1 is not an
               doi: 10.1038/s41467-023-39414-4                    essential component of nuclear speckles in mice.  RNA.
            133. Lemster AL, Weingart A, Bottner J, et al. Elevated PSPC1   2012;18:1487-1499.
               and KDM5C expression indicates poor prognosis in prostate      doi: 10.1261/rna.033217.112
               cancer. Hum Pathol. 2023;138:1-11.
                                                               144. Arratia F, Fierro C, Blanco A, et al. Selective concurrence
               doi: 10.1016/j.humpath.2023.05.007                 of the long non-coding RNA MALAT1 and the polycomb
            134. Tyzack  GE,  Manferrari  G,  Newcombe  J,  Luscombe  NM,   repressive complex 2 to the promoter regions of active
               Luisier R, Patani R. Paraspeckle components NONO and   genes  in MCF7 breast cancer  cells. Curr Issues Mol Biol.
               PSPC1 are not mislocalized from motor neuron nuclei in   2023;45(6):4735-4748.
               sporadic ALS. Brain. 2020;143(8):e66.              doi: 10.3390/cimb45060301
               doi: 10.1093/brain/awaa205                      145. Frappier  L. Viral disruption of  promyelocytic  leukemia
            135. Harley J, Hagemann C, ASerio A, Patani R. TDP-43 and FUS   (PML) nuclear bodies by hijacking host PML regulators.
               mislocalization in VCP mutant motor neurons is reversed by   Virulence. 2011;2(1):58-62.
               pharmacological inhibition of the VCP D2 ATPase domain.      doi: 10.4161/viru.2.1.14610
               Brain Commun. 2021;3:fcab166.
                                                               146. Huang WH, Su WM, Wang CW,  et al. The Momordica
               doi: 10.1093/braincomms/fcab166                    anti-HIV protein MAP30 abrogates the Epstein-Barr virus
            136. Shao W, Bi X, Pan Y, et al. Phase separation of RNA-binding   nuclear antigen 1-dependent functions in host cells. Heliyon.
               protein  promotes  polymerase  binding  and  transcription.   2023;9(11):e21486.
               Nat Chem Biol. 2022;18(1):70-80.                   doi: 10.1016/j.heliyon.2023.e21486
               doi: 10.1038/s41589-021-00904-5                 147. D’Amico F, Mukhopadhyay R, Ovaa H, Mulder  MPC.
            137. Yeh HW, Hsu EC, Lee SS,  et al. PSPC1 mediates TGF-  Targeting  TRIM  proteins:  A   quest  toward
               β1 autocrine signaling and Smad2/3 target switching to   drugging an emerging protein class.  Chembiochem.
               promote EMT, stemness and metastasis. Nat Cell Biol.   2021;22(12):2011-2031.
               2018;20(4):479-491.
                                                                  doi: 10.1002/cbic.202000787
               doi: 10.1038/s41556-018-0062-y.
                                                               148. Dodel M, Guiducci G, Dermit M,  et al. TREX reveals
            138. Li J, Cui P, Sun Q,  et  al. PSPC1 regulates CHK1   proteins that bind to specific RNA regions in living cells. Nat


            Volume 3 Issue 4 (2024)                         32                                doi: 10.36922/td.4657
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