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Tumor Discovery                                          Pyrotinib and capecitabine in HER2-negative recurrence



            Investigation: Yuling Zhang, Bingfeng Chen            significance. Mod Pathol. 2012;25(7):938-948.
            Methodology: Chunfa Chen                              doi: 10.1038/modpathol.2012.36
            Writing–original draft: Yuling Zhang
            Writing–review & editing: Chunfa Chen, Jundong Wu  7.   Hou Y, Nitta H, Wei L,  et  al. HER2 intratumoral
                                                                  heterogeneity is independently associated with incomplete
            Ethics approval and consent to participate            response to anti-HER2 neoadjuvant chemotherapy in
                                                                  HER2-positive breast carcinoma.  Breast Cancer Res Treat.
            The study was approved by the Ethics Committee of the   2017;166(2):447-457.
            Cancer Hospital of Shantou University Medical College
            (approval no.: 2022139).                              doi: 10.1007/s10549-017-4453-8
                                                               8.   Lee HJ, Seo AN, Kim EJ, et al. HER2 heterogeneity affects
            Consent for publication                               trastuzumab responses and survival in patients with

            Written informed consent was obtained from the patient   HER2-positive metastatic breast cancer. Am J Clin Pathol.
                                                                  2014;142(6):755-766.
            for publication of the details of her medical case and any
            accompanying images. A  copy of the written consent is      doi: 10.1309/AJCPIRL4GUVGK3YX
            available for review by the Editor-in-Chief of this journal   9.   Guarneri  V,  Dieci  MV,  Barbieri  E,  et al.  Loss  of  HER2
            upon request.                                         positivity and prognosis after neoadjuvant therapy
                                                                  in  HER2-positive  breast  cancer  patients.  Ann Oncol.
            Availability of data                                  2013;24(12):2990-2994.

            Not applicable.                                       doi: 10.1093/annonc/mdt364
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            Volume 4 Issue 1 (2025)                        118                                doi: 10.36922/td.4093
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