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Tumor Discovery                                                    EpCAM-targeting cancer immunotherapies



            38.  Bellone S, Black J, English DP,  et  al. Solitomab, an   Samara P. Harnessing the immune system to improve cancer
               EpCAM/CD3 bispecific antibody construct (BiTE), is   therapy. Ann Transl Med. 2016;4:261.
               highly active against primary uterine serous papillary      doi: 10.21037/atm.2016.04.01
               carcinoma cell lines  in vitro.  Am J Obstet Gynecol.
               2016;214:99.e1-99.e8.                           50.  Lv Y, Zhang H, Cui Z, et al. Gene delivery to breast cancer by
                                                                  incorporated EpCAM targeted DARPins into AAV2. BMC
               doi: 10.1016/j.ajog.2015.08.011
                                                                  Cancer. 2023;23:1220.
            39.  Li D, Guo X, Yang K, et al. EpCAM-targeting CAR-T cell      doi: 10.1186/s12885-023-11705-5
               immunotherapy is safe and efficacious for epithelial tumors.
               Sci Adv. 2023;9:eadg9721.                       51.  Tavsan Z, Ayar Kayalı H. EpCAM-claudin-tetraspanin-
                                                                  modulated ovarian cancer progression and drug resistance.
               doi: 10.1126/sciadv.adg9721
                                                                  Cell Adh Migr. 2020;14:57-68.
            40.  Yu  YD,  Kim  TJ.  Chimeric  antigen  receptor-engineered  T      doi: 10.1080/19336918.2020.1732761
               cell therapy for the management of patients with metastatic
               prostate cancer: A  comprehensive review.  Int J Mol Sci.   52.  Ni J, Cozzi P, Beretov J, et al. Epithelial cell adhesion molecule
               2021;22:640.                                       (EpCAM) is associated with prostate cancer progression and
                                                                  chemo-/radio-resistance in vitro and in vivo. BMC Cancer.
               doi: 10.3390/ijms22020640
                                                                  2017;18:2833-2833.
            41.  Ashley EA. Towards precision medicine.  Nat Rev Genet.      doi: 10.1158/1538-7445.am2017-2833
               2016;17:507-522.
                                                               53.  Mal A, Bukhari AB, Singh RK, et al. EpCAM-mediated cellular
               doi: 10.1038/nrg.2016.86
                                                                  plasticity promotes radiation resistance and metastasis in
            42.  Arrowsmith J, Miller P. Trial watch: Phase II and phase III   breast cancer. Front Cell Dev Biol. 2021;8:597673.
               attrition rates 2011-2012. Nat Rev Drug Discov. 2013;12:569.
                                                                  doi: 10.3389/fcell.2020.597673
               doi: 10.1038/nrd4090
                                                               54.  Hristodorov D, Amoury M, Mladenov R,  et al. EpCAM-
            43.  Mak IW, Evaniew N, Ghert M. Lost in translation: Animal   selective  elimination  of  carcinoma  cells  by  a  novel
               models and clinical trials in cancer treatment. Am J Transl   MAP-based cytolytic fusion protein.  Mol Cancer Ther.
               Res. 2014;6(2):114-118.                            2014;13:2194-2202.
            44.  Ryaboshapkina M, Hammar M. Tissue-specific genes      doi: 10.1158/1535-7163.MCT-13-0781
               as  an  underutilized  resource  in  drug  discovery.  Sci   55.  Qu W, Meng B, Yu Y, Wang S. EpCAM antibody-conjugated
               Rep. 2019;9:7233.
                                                                  mesoporous silica nanoparticles to enhance the anticancer
               doi: 10.1038/s41598-019-43829-9                    efficacy of carboplatin in retinoblastoma. Mater Sci Eng C.
                                                                  2017;76:646-651.
            45.  Nguyen PA, Born DA, Deaton AM, Nioi P, Ward LD.
               Phenotypes  associated with genes  encoding drug  targets      doi: 10.1016/j.msec.2017.03.036
               are predictive of clinical trial side effects.  Nat Commun.   56.  Kapka-Skrzypczak L, Popek S, Sawicki K, et al. IL-6 prevents
               2019;10:1579.
                                                                  CXCL8-induced stimulation of EpCAM expression in
               doi: 10.1038/s41467-019-09407-3                    ovarian cancer cells. Mol Med Rep. 2019;19:2317-2322.
            46.  Sinkala M, Naran K, Ramamurthy D, et al. Machine learning      doi: 10.3892/mmr.2019.9890
               and bioinformatic analyses link the cell surface receptor   57.  Zhang BL, Li D, Gong YL,  et al. Preclinical evaluation
               transcript levels to the drug response of breast cancer cells   of chimeric antigen receptor-modified T cells specific to
               and drug off-target effects. PLoS One. 2024;19:e0296511.
                                                                  epithelial cell adhesion molecule for treating colorectal
               doi: 10.1371/journal.pone.0296511                  cancer. Hum Gene Ther. 2019;30:402-412.
            47.  Wayne  AS,  Fitzgerald  DJ,  Kreitman  RJ,  Pastan  I.      doi: 10.1089/hum.2018.229
               Immunotoxins for leukemia. Blood. 2015;123:2470-2478.
                                                               58.  Zhang Y, Xie X, Yeganeh PN,  et al. Immunotherapy for
               doi: 10.1182/blood-2014-01-492256.2470             breast cancer using EpCAM aptamer tumor-targeted
                                                                  gene knockdown.  Proc Natl Acad Sci U S A. 2021;118:
            48.  Morgan  RN,  Saleh  ES,  Farrag  AH,  Aboshanab  MK.  New
               insights on Pseudomonas aeruginosa exotoxin A-based   e2022830118.
               immunotoxins in targeted cancer therapeutic delivery. Ther      doi: 10.1073/pnas.2022830118
               Deliv. 2023;14:31-60.
                                                               59.  Kouba P, Kohout P, Haddadi F, et al. Machine learning-guided
               doi: 10.4155/tde-2022-0055                         protein engineering. ACS Catal. 2023;13:13863-13895.
            49.  Papaioannou NE, Beniata OV, Vitsos P, Tsitsilonis O,      doi: 10.1021/acscatal.3c02743



            Volume 4 Issue 1 (2025)                         12                                doi: 10.36922/td.4926
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