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Tumor Discovery Melanoma exosomes in metastasis

Writing – original draft: Manting Luo, Huirong Hong, doi: 10.3390/cancers12102923
Jianlong Li 9. Dilsiz N. Role of exosomes and exosomal microRNAs in
Writing – review & editing: Manting Luo, Jianlong Li cancer. Fut Sci OA. 2020;6:FSO465.

Ethics approval and consent to participate doi: 10.2144/fsoa-2019-0116
Not applicable. 10. Sabag N, Yakobson A, Retchkiman M, Silberstein E. Novel
biomarkers and therapeutic targets for melanoma. Int J Mol
Consent for publication Sci. 2022;23:11656.
Not applicable. doi: 10.3390/ijms231911656
11. Reschke R, Enk AH, Hassel JC. Chemokines and cytokines
Availability of data in immunotherapy of melanoma and other tumors: From
biomarkers to therapeutic targets. Int J Mol Sci. 2024;25:6532.
Not applicable.
doi: 10.3390/ijms25126532
References 12. Panda SS, Sahoo RK, Patra SK, Biswal S, Biswal BK. Molecular
1. Long GV, Swetter SM, Menzies AM, Gershenwald JE, insights to therapeutic in cancer: Role of exosomes in
Scolyer RA. Cutaneous melanoma. Lancet. 2023;402:485-502. tumor microenvironment, metastatic progression and drug
resistance. Drug Discov Today. 2024;29:104061.
doi: 10.1016/s0140-6736(23)00821-8
doi: 10.1016/j.drudis.2024.104061
2. Davey MG, Miller N, McInerney NM. A review of
epidemiology and cancer biology of malignant melanoma. 13. Peinado H, Alečković M, Lavotshkin S, et al. Melanoma
Cureus. 2021;13:e15087. exosomes educate bone marrow progenitor cells toward
a pro-metastatic phenotype through MET. Nat Med.
doi: 10.7759/cureus.15087
2012;18:883-891.
3. Waseh S, Lee JB. Advances in melanoma: Epidemiology,
diagnosis, and prognosis. Front Med. 2023;10:1268479. doi: 10.1038/nm.2753
14. Damsky WE, Rosenbaum LE, Bosenberg M. Decoding
doi: 10.3389/fmed.2023.1268479
melanoma metastasis. Cancers (Basel). 2011;3:126-163.
4. Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA. The doi: 10.3390/cancers3010126
2018 World Health organization classification of cutaneous,
mucosal, and uveal melanoma: Detailed analysis of 9 distinct 15. Yoo H, Kim H, Kwon ST, et al. Tumor invasion in the
subtypes defined by their evolutionary pathway. Arch Pathol hyponychium is associated with distant metastasis and poor
Lab Med. 2020;144:500-522. prognosis in subungual melanoma: A histologic landscape
of 44 cases. J Am Acad Dermatol. 2022;86:1027-1034.
doi: 10.5858/arpa.2019-0561-RA
doi: 10.1016/j.jaad.2021.06.847
5. Davis LE, Shalin SC, Tackett AJ. Current state of melanoma
diagnosis and treatment. Cancer Biol Ther. 2019;20:1366-1379. 16. Boutros A, Croce E, Ferrari M, et al. The treatment
of advanced melanoma: Current approaches and new
doi: 10.1080/15384047.2019.1640032
challenges. Crit Rev Oncol Hematol. 2024;196:104276.
6. Xiao D, Barry S, Kmetz D, et al. Melanoma cell-derived
exosomes promote epithelial-mesenchymal transition in doi: 10.1016/j.critrevonc.2024.104276
primary melanocytes through paracrine/autocrine signaling in 17. Lepletier A, Madore J, O’Donnell JS, et al. Tumor CD155
the tumor microenvironment. Cancer Lett. 2016;376:318-327. expression is associated with resistance to anti-PD1
immunotherapy in metastatic melanoma. Clin Cancer Res.
doi: 10.1016/j.canlet.2016.03.050
2020;26:3671-3681.
7. Chen Y, Fang Y, Li L, Luo H, Cao T, Tu B. Exosomal
miR-22-3p from mesenchymal stem cells inhibits the doi: 10.1158/1078-0432.Ccr-19-3925
epithelial-mesenchymal transition (EMT) of melanoma 18. Corrales E, Levit-Zerdoun E, Metzger P, et al. PI3K/AKT
cells by regulating LGALS1. Front Biosci (Landmark Ed). signaling allows for MAPK/ERK pathway independency
2022;27:275. mediating dedifferentiation-driven treatment resistance in
melanoma. Cell Commun Signal. 2022;20:187.
doi: 10.31083/j.fbl2709275
doi: 10.1186/s12964-022-00989-y
8. Tsering T, Laskaris A, Abdouh M, et al. Uveal melanoma-
derived extracellular vesicles display transforming potential 19. Tang X, Rao J, Yin S, et al. PD-L1 knockdown via hybrid
and carry protein cargo involved in metastatic niche micelle promotes paclitaxel induced cancer-immunity cycle
preparation. Cancers (Basel). 2020;12:2923. for melanoma treatment. Eur J Pharm Sci. 2019;127:161-174.

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