Page 26 - TD-4-2
P. 26

Tumor Discovery                                                         Melanoma exosomes in metastasis



               squamous cell carcinoma, a malignant transformation of   progression and metastasis. Nat Med. 2013;19:1423-1437.
               actinic keratoses. Eur J Pharm Biopharm. 2012;81:102-112.
                                                                  doi: 10.1038/nm.3394
               doi: 10.1016/j.ejpb.2012.02.008
                                                               99.  Ambrosini G, Rai AJ, Carvajal RD, Schwartz GK.
            88.  Shao J, Zaro J, Shen Y. Advances in exosome-based drug   Uveal melanoma exosomes induce a prometastatic
               delivery and tumor targeting: From tissue distribution to   microenvironment  through  macrophage  migration
               intracellular fate. Int J Nanomed. 2020;15:9355-9371.  inhibitory factor. Mol Cancer Res. 2022;20:661-669.
               doi: 10.2147/ijn.S281890                           doi: 10.1158/1541-7786.Mcr-21-0526
            89.  Horodecka K, Düchler M. CRISPR/Cas9: Principle,   100. Li J, Cai J, Zhao S, et al. GANT61, a GLI inhibitor, sensitizes
               applications, and delivery through extracellular vesicles. Int   glioma cells to the temozolomide treatment.  J  Exp Clin
               J Mol Sci. 2021;22:6072.                           Cancer Res. 2016;35:184.
               doi: 10.3390/ijms22116072                          doi: 10.1186/s13046-016-0463-3
            90.  Shi A, Li J, Qiu X, et al. TGF-β loaded exosome enhances   101. Tan Y,  Tang F,  Li J, et al. Tumor-derived  exosomes:  The
               ischemic wound healing in vitro and in vivo. Theranostics.   emerging orchestrators in melanoma. Biomed Pharmacother.
               2021;11:6616-6631.                                 2022;149:112832.
               doi: 10.7150/thno.57701                            doi: 10.1016/j.biopha.2022.112832
            91.  Poongodi R, Chen YL, Yang TH, et al. Bio-scaffolds as cell   102. Gyukity-Sebestyén E, Harmati M, Dobra G, et al. Melanoma-
               or exosome carriers for nerve injury repair. Int J Mol Sci.   derived exosomes induce PD-1 overexpression and
               2021;22:13347.                                     tumor progression via mesenchymal stem cell oncogenic
                                                                  reprogramming. Front Immunol. 2019;10:2459.
               doi: 10.3390/ijms222413347
                                                                  doi: 10.3389/fimmu.2019.02459
            92.  Moghaddam AS, Afshari JT, Esmaeili SA, Saburi E,
               Joneidi Z, Momtazi-Borojeni AA. Cardioprotective microRNAs:   103. Li T, Wu T, Li X, Qian C. Transcriptional switches in
               Lessons from stem cell-derived exosomal microRNAs to treat   melanoma T Cells: Facilitating polarizing into regulatory T
               cardiovascular disease. Atherosclerosis. 2019;285:1-9.  cells. Int Immunopharmacol. 2024;137:112484.
               doi: 10.1016/j.atherosclerosis.2019.03.016         doi: 10.1016/j.intimp.2024.112484
            93.  Shen Z, Huang W, Liu J, Tian J, Wang S, Rui K. Effects of   104. Asleh K, Dery V, Taylor C, et al. Extracellular vesicle-based
               mesenchymal stem cell-derived exosomes on autoimmune   liquid biopsy biomarkers and their application in precision
               diseases. Front Immunol. 2021;12:749192.           immuno-oncology. Biomarker Res. 2023;11:99.
               doi: 10.3389/fimmu.2021.749192                     doi: 10.1186/s40364-023-00540-2
            94.  Yang B, Chen Y, Shi J. Exosome biochemistry and advanced   105. Pathania AS, Prathipati P, Challagundla KB. New insights
               nanotechnology for next-generation theranostic platforms.   into exosome mediated tumor-immune escape: Clinical
               Adv Mater. 2019;31:e1802896.                       perspectives  and  therapeutic  strategies.  Biochim Biophys
                                                                  Acta Rev Cancer. 2021;1876:188624.
               doi: 10.1002/adma.201802896
                                                                  doi: 10.1016/j.bbcan.2021.188624
            95.  Kim  H, Kim  H,  Feng  Y, et al. PRMT5  control of  cGAS/
               STING and NLRC5 pathways defines melanoma response   106. Petersen KE, Manangon E, Hood JL, et al.  A  review of
               to antitumor immunity. Sci Transl Med. 2020;12:eaaz5683.  exosome separation techniques and characterization of B16-
                                                                  F10 mouse melanoma exosomes with AF4-UV-MALS-DLS-
               doi: 10.1126/scitranslmed.aaz5683
                                                                  TEM. Anal Bioanal Chem. 2014;406:7855-7866.
            96.  Najem A, Soumoy L, Sabbah M, et al. Understanding      doi: 10.1007/s00216-014-8040-0
               molecular mechanisms of phenotype switching and crosstalk
               with TME to reveal new vulnerabilities of melanoma. Cells.   107. Zhu L, Kalimuthu S, Gangadaran P, et al. Exosomes derived
               2022;11:1157.                                      from natural killer cells exert therapeutic effect in melanoma.
                                                                  Theranostics. 2017;7:2732-2745.
               doi: 10.3390/cells11071157
                                                                  doi: 10.7150/thno.18752
            97.  Wei  CY,  Zhu  MX,  Yang  YW, et al.  Downregulation  of
               RNF128 activates Wnt/β-catenin signaling to induce cellular   108. Erman A, Ignjatović M, Leskovšek K, et al. The prognostic
               EMT and stemness via CD44 and CTTN ubiquitination in   and predictive value of human gastrointestinal microbiome
               melanoma. J Hematol Oncol. 2019;12:21.             and exosomal mRNA expression of PD-L1 and IFNγ for
                                                                  immune checkpoint inhibitors response in metastatic
               doi: 10.1186/s13045-019-0711-z
                                                                  melanoma patients: PROTOCOL TRIAL.  Biomedicines.
            98.  Quail DF, Joyce JA. Microenvironmental regulation of tumor   2023;11:2016.


            Volume 4 Issue 2 (2025)                         18                                doi: 10.36922/td.7108
   21   22   23   24   25   26   27   28   29   30   31