Page 27 - TD-4-2

Tumor Discovery Melanoma exosomes in metastasis

doi: 10.3390/biomedicines11072016 function, diagnostic and targeted therapy applications, and
clinical trials. J Biomed Sci. 2024;31:67.
109. Li P, Xie Y, Wang J, et al. Gene engineered exosome reverses
T cell exhaustion in cancer immunotherapy. Bioact Mater. doi: 10.1186/s12929-024-01055-0
2024;34:466-481.
116. Singh K, Nalabotala R, Koo KM, Bose S, Nayak R,
doi: 10.1016/j.bioactmat.2024.01.008 Shiddiky MJA. Separation of distinct exosome subpopulations:
Isolation and characterization approaches and their associated
110. Wang X, Tian L, Lu J, Ng IO. Exosomes and cancer-
diagnostic and prognostic biomarkers and therapeutic challenges. Analyst. 2021;146:3731-3749.
vehicle. Oncogenesis. 2022;11:54. doi: 10.1039/d1an00024a
doi: 10.1038/s41389-022-00431-5 117. Paganini C, Palmiero UC, Pocsfalvi G, Touzet N,
Bongiovanni A, Arosio P. Scalable production and
111. Ye Y, Shi Q, Yang T, et al. In vivo visualized tracking of tumor- isolation of extracellular vesicles: Available sources and
derived extracellular vesicles using CRISPR-Cas9 system. lessons from current industrial bioprocesses. Biotechnol J.
Technol Cancer Res Treat. 2022;21:15330338221085370.
2019;14:e1800528.
doi: 10.1177/15330338221085370
doi: 10.1002/biot.201800528
112. Sutherland TE, Dyer DP, Allen JE. The extracellular matrix 118. Wang CK, Tsai TH, Lee CH. Regulation of exosomes as
and the immune system: A mutually dependent relationship. biologic medicines: Regulatory challenges faced in exosome
Science. 2023;379:eabp8964.
development and manufacturing processes. Clin Transl Sci.
doi: 10.1126/science.abp8964 2024;17:e13904.
113. Agarwal P, Crepps MP, Stahr NA, et al. Identification of doi: 10.1111/cts.13904
canine circulating miRNAs as tumor biospecific markers 119. Sharma A, Yadav A, Nandy A, Ghatak S. Insight into
using Next-generation sequencing and Q-RT-PCR. Biochem the functional dynamics and challenges of exosomes
Biophys Rep. 2021;28:101106.
in pharmaceutical innovation and precision medicine.
doi: 10.1016/j.bbrep.2021.101106 Pharmaceutics. 2024;16:709.
114. Yamashita T, Takahashi Y, Takakura Y. Possibility of doi: 10.3390/pharmaceutics16060709
exosome-based therapeutics and challenges in production 120. Hu S, Ma J, Su C, et al. Engineered exosome-like
of exosomes eligible for therapeutic application. Biol Pharm nanovesicles suppress tumor growth by reprogramming
Bull. 2018;41:835-842.
tumor microenvironment and promoting tumor ferroptosis.
doi: 10.1248/bpb.b18-00133 Acta Biomater. 2021;135:567-581.
115. Chen YF, Luh F, Ho YS, Yen Y. Exosomes: A review of biologic doi: 10.1016/j.actbio.2021.09.003

Volume 4 Issue 2 (2025) 19 doi: 10.36922/td.7108