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Tumor Discovery

CASE REPORT
Chemotherapy-induced ileus and

gastrointestinal hemorrhage following therapy
with BrECADD for Hodgkin lymphoma: A case

report

Karl Mayrhofer* and Simon Udovica
Department of Internal Medicine I., Centre for Oncology and Haematology, Vienna Healthcare
Group, Ottakring, Vienna, Austria

Abstract

A 62-year-old male with newly diagnosed advanced-stage Hodgkin lymphoma
(HL) developed life-threatening gastrointestinal (GI) complications during
brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine,
and dexamethasone chemotherapy. He presented with chemotherapy-induced
enteritis and jejunal ileus, followed by severe GI bleeding requiring two consecutive
laparotomies and segmental jejunal resections. Histology revealed ulcerative jejunitis
without signs of lymphoma infiltration. His medical course was further complicated
by acute renal failure requiring dialysis. Although the patient temporarily stabilized
*Corresponding author:
Karl Mayrhofer with intensive care management, he subsequently developed Candida sepsis. At the
(karl.mayrhofer@posteo.de) time of submission, his outcome remains uncertain. This case underscores a rare but
Citation: Mayrhofer K, Udovica S. serious occurrence of GI toxicity associated with intensive chemotherapy for HL.
Chemotherapy-induced ileus
and gastrointestinal hemorrhage
following therapy with BrECADD for Keywords: Ileus; Enteritis; Hemorrhage; BrECADD; Hodgkin lymphoma
Hodgkin lymphoma: A case report.
Tumor Discov. 2025;4(3):105-109.
doi: 10.36922/TD025180033
Received: May 1, 2025 1. Background
Revised: June 12, 2025 Hodgkin lymphoma (HL) is a highly curable malignancy with a range of effective
Accepted: July 2, 2025 chemotherapeutic regimens. While hematological and infectious complications are well-
documented, gastrointestinal (GI) complications such as chemotherapy-induced ileus
Published online: July 21, 2025
remain poorly characterized. This report presents a rare case of enteritis complicated by
Copyright: © 2025 Author(s). ileus, GI hemorrhage, and renal failure, following brentuximab vedotin (BV), etoposide,
This is an Open-Access article
distributed under the terms of the cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone (BrECADD)
Creative Commons Attribution chemotherapy. 1
License, permitting distribution,
and reproduction in any medium, 2. Case presentation
provided the original work is
properly cited. A 62-year-old male patient with a medical history of arterial hypertension, obesity,
Publisher’s Note: AccScience and hypothyroidism presented for evaluation of prolonged coughing. Imaging studies
Publishing remains neutral with revealed extensive mediastinal tumor mass, bilateral pleural effusions, and a pericardial
regard to jurisdictional claims in
published maps and institutional effusion. A computed tomography-guided biopsy confirmed the diagnosis of HL. The
affiliations. patient was then referred to our oncology department for treatment initiation.

Volume 4 Issue 3 (2025) 105 doi: 10.36922/TD025180033