Page 108 - TD-4-3

Tumor Discovery

CASE REPORT
Challenges and considerations in diagnosing

mature teratoma during pregnancy: A case
report

Sumaira Siddiqui*

Department of Pathology, Clinilabs and Research, Lucknow, Uttar Pradesh, India

Abstract

The progression of rapidly growing teratomas in pregnancy may be influenced by
hormonal and genetic factors. The current report is about a unique case involving
a mature teratoma with rapid growth characteristics, yet it did not lead to any
complications throughout pregnancy of a primigravida. The benign mature teratoma
was identified via antenatal ultrasound during the first trimester. In this case, the
patient experienced no adverse effects, and the size of the ovarian teratoma showed
a gradual increasing trend during pregnancy without resulting in any complications.
In summary, mature teratoma is a benign tumor with a good prognosis, and if fetal
distress is detected, cesarean section should be recommended.

Keywords: Mature teratoma; Pregnancy; Fetal distress; Cesarean section
*Corresponding author:
Sumaira Siddiqui
(sumiimc011@gmail.com)
Citation: Siddiqui S. Challenges 1. Introduction
and considerations in diagnosing
mature teratoma during pregnancy: Cystic teratomas represent a form of germ-cell tumor distinguished by the presence of
A case report. Tumor Discov. mature tissues from all three embryonic layers: ectoderm, mesoderm, and endoderm.
2025;4(3):100-104.
doi: 10.36922/TD025120022 Remarkably, evidence of teratomas dates back to 2000 B.C., demonstrating the long-
standing recognition of these tumors. The first formally recorded case of a mature
Received: March 20, 2025
cystic teratoma was made by Johannes Scultetus in 1659, who documented the
1st revised: April 30, 2025 ovarian tumor findings of a young woman during the autopsy, describing it as a
1
2nd revised: June 1, 2025 “dermoid cyst.” Rudolf Virchow introduced the term “teratoma” in 1863, derived
from the Greek word “teras,” which means monster. Mature cystic teratomas are
2
Accepted: June 3, 2025
considered benign, with an average growth rate of 1.8 mm/year, although malignant
Published online: June 30, 2025 transformation has been reported in rare cases. The development of mature cystic
Copyright: © 2025 Author(s). teratomas is associated with several risk factors, including late menarche with
This is an Open-Access article menstrual irregularities, alcohol use, a history of cystic teratomas, fewer pregnancies,
distributed under the terms of the
Creative Commons Attribution infertility, and adolescent’s physical activity that may contribute to an anovulatory
License, permitting distribution, cycle. Mature teratomas are benign tumors of the ovary that have a generally
3
and reproduction in any medium, favorable prognosis and account for <1% of ovarian tumors. Their occurrence during
provided the original work is
4
properly cited. pregnancy is uncommon. Notably, the hormonal changes during pregnancy cause an
increase in the size of mature teratoma.
Publisher’s Note: AccScience
Publishing remains neutral with The current report is about a unique case involving a mature teratoma with rapid
regard to jurisdictional claims in
published maps and institutional growth characteristics, yet it did not lead to any complications throughout pregnancy
affiliations. of a primigravida.
Volume 4 Issue 3 (2025) 100 doi: 10.36922/TD025120022