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Artificial Intelligence in Health                                  Predicting mortality in COVID-19 using ML



            of the top-performing models: XGBoost, RF (precision:   disease-covid-19 [Last accessed on 2023 Dec 13].
            93.66%, recall: 96.99%, F1-score: 91.13%, AUC-ROC:   2.   Statement on the Second Meeting of the International Health
            97.71%, and runtime: 29.84745 s), MLPs (precision: 93.46%,   Regulations (2005) Emergency Committee Regarding the
            recall: 95.62%, F1-score: 90.76%, AUC-ROC: 97.29%, and   Outbreak of Novel Coronavirus (2019-nCoV). World Health
            runtime: 133.76172 s), and DTs (precision: 93.04%, recall:   Organization; 2020. Available from: https://www.who.int/
            93.69%, F1-score: 90.03%, AUC-ROC: 95.67%, and runtime:   news/item/30-01-2020-statement-on-the-second-meeting-
            1.45128  s).  In  addition,  this  work  could  be  expanded  to   of-the-international-health-regulations-(2005)-emergency-
            include  viral  diseases  from  previous  pandemics,  such  as   committee-regarding-the-outbreak-of-novel-coronavirus-
            SARS, H1N1, MERS, and Ebola, in the interest of identifying   (2019-ncov) [Last accessed on 2023 Dec 18].
            the ML models with the highest overall performance.  3.   WHO Director-General’s Opening Remarks at the Media
                                                                  Briefing on COVID-19. World Health Organization; 2020.
            Acknowledgments                                       Available  from:  https://www.who.int/director-general/

            The authors wish to acknowledge the Health Informatics   speeches/detail/who-director-general-s-opening-remarks-
                                                                  at-the-media-briefing-on-covid-19---11-march-2020 [Last
            Laboratory, Faculty of Nursing, National and Kapodistrian   accessed on 2023 Dec  .
                                                                                  18
            University of Athens (Athens, Greece) for providing the
            facilities needed for this research study.         4.   WHO Coronavirus (COVID-19) Dashboard.  WHO
                                                                  Coronavirus (COVID-19) Dashboard With Vaccination
            Funding                                               Data. World Health Organization; 2023. Available from:
                                                                  https://covid19.who.int [Last accessed on 2023 Dec 18].
            None.
                                                               5.   Naming the Coronavirus Disease (COVID-19) and the
            Conflict of interest                                  Virus that Causes it. World Health Organization; 2023.
                                                                  Available from: https://www.who.int/emergencies/diseases/
            The authors declare that they have no competing interests.  novel-coronavirus-2019/technical-guidance/naming-the-
                                                                  coronavirus-disease-(covid-2019)-and-the-virus-that-
            Author contributions                                  causes-it [Last accessed on 2023 Dec 18].
            Conceptualization: Nikolaos Kourmpanis, John Mantas   6.   Machhi J, Herskovitz J, Senan AM, et al. The natural history,
            Investigation: Nikolaos Kourmpanis, Joseph Liaskos    pathobiology, and clinical manifestations of SARS-CoV-2
            Methodology: All authors                              infections. J Neuroimmune Pharmacol. 2020;15(3):359-386.
            Writing – original draft: Nikolaos Kourmpanis         doi: 10.1007/s11481-020-09944-5
            Writing – review & editing: All authors
                                                               7.   Zhou P, Yang XL, Wang XG, et al. Addendum: A pneumonia
            Ethics approval and consent to participate            outbreak associated with a new coronavirus of probable bat
                                                                  origin. Nature. 2020;588(7836):E6.
            Not applicable.
                                                                  doi: 10.1038/s41586-020-2951-z
            Consent for publication                            8.   Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-
                                                                  CoV-2  cell  entry  depends  on  ACE2 and  TMPRSS2  and
            Not applicable.                                       is blocked by a clinically proven protease inhibitor.  Cell.
            Availability of data                                  2020;181(2):271-280.e8.
                                                                  doi: 10.1016/j.cell.2020.02.052
            The dataset can be retrieved through a link provided by
            the Government of Mexico (https://www.gob.mx/salud/  9.   Lednicky JA, Tagliamonte MS, White SK, et al. Independent
            documentos/datos-abiertos-152127).                    infections of porcine deltacoronavirus among Haitian
                                                                  children. Nature. 2021;600(7887):133-137.
            Further disclosure                                    doi: 10.1038/s41586-021-04111-z
            Part of the findings has been presented in the     10.  Vlasova AN, Diaz A, Damtie D, et al. Novel canine coronavirus
            21  International Conference on Informatics, Management   isolated from a hospitalized patient with pneumonia in east
              st
            and  Technology  in  Healthcare  (ICIMTH  2023)  held  in   Malaysia. Clin Infect Dis. 2022;74(3):446-454.
            Athens, Greece, from July 1 – 3, 2023.                doi: 10.1093/cid/ciab456
            References                                         11.  Lytras S, Hughes J, Martin D, et al. Exploring the natural
            1.   Coronavirus  Disease  (COVID-19).  World  Health  origins of SARS-CoV-2 in the light of recombination.
               Organization; 2023. Available from: https://www.who.int/  Genome Biol Evol. 2022;14(2):evac018.
               news-room/questions-and-answers/item/coronavirus-     doi: 10.1093/gbe/evac018


            Volume 1 Issue 3 (2024)                         50                               doi: 10.36922/aih.2591
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