Page 79 - AN-1-2
P. 79
Advanced Neurology NMDA receptors in neuropsychiatric diseases
Bioorg Med Chem Lett, 12: 1099–1102. 185. Fischer G, et al., 1997, Ro 25-6981, a highly potent and
selective blocker of N-methyl-D-aspartate receptors
https://doi.org/1016/s0960-894x(02)00074-4
containing the NR2B subunit. Characterization in vitro.
175. Hood WF, Sun ET, Compton RP, et al., 1989, J Pharmacol Exp Ther, 283: 1285–1292.
1-Aminocyclobutane-1-carboxylate (ACBC): A specific
antagonist of the N-methyl-D-aspartate receptor coupled 186. Bettini E, Sava A, Griffante C, et al., 2010, Identification
glycine receptor. Eur J Pharmacol, 161: 281–282. and characterization of novel NMDA receptor antagonists
selective for NR2A- over NR2B-containing receptors.
https://doi.org/1016/0014-2999(89)90861-3 J Pharmacol Exp Ther, 335: 636–644.
176. Kemp JA, Foster AC, Leeson PD, et al., 1988, https://doi.org/1124/jpet.110.172544
7-Chlorokynurenic acid is a selective antagonist at the
glycine modulatory site of the N-methyl-D-aspartate 187. Hansen KB, Ogden KK, Traynelis SF, 2012, Subunit-selective
receptor complex. Proc Natl Acad Sci U S A, 85: 6547–6550. allosteric inhibition of glycine binding to NMDA receptors.
J Neurosci, 32: 6197–6208.
https://doi.org/1073/pnas.85.17.6547
https://doi.org/1523/JNEUROSCI.5757-11.2012
177. Davies J, Watkins JC, 1972, Is 1-hydroxy-3-
aminopyrrolidone-2 (HA-966) a selective excitatory amino- 188. Edman S, McKay S, MacDonald LJ, et al., 2012, TCN 201
acid antagonist? Nat New Biol, 238: 61–63. selectively blocks GluN2A-containing NMDARs in a
GluN1 co-agonist dependent but non-competitive manner.
https://doi.org/1038/newbio238061a0 Neuropharmacology, 63: 441–449.
178. Priestley T, Laughton P, Macaulay AJ, et al., 1996, https://doi.org/1016/j.neuropharm.2012.04.
Electrophysiological characterisation of the antagonist
properties of two novel NMDA receptor glycine site 189. Mosley CA, Acker TM, Hansen KB, et al., 2010, Quinazolin-
antagonists, L-695,902 and L-701,324. Neuropharmacology, 4-one derivatives: A novel class of noncompetitive
35: 1573–1581. NR2C/D subunit-selective N-methyl-D-aspartate receptor
antagonists. J Med Chem, 53: 5476–5490.
https://doi.org/1016/s0028-3908(96)00141-4
https://doi.org/1021/jm100027p
179. Anis N, Sherby S, Goodnow R Jr., et al., 1990, Structure-
activity relationships of philanthotoxin analogs and 190. Hansen KB, Traynelis SF, 2011, Structural and mechanistic
polyamines on N-methyl-D-aspartate and nicotinic determinants of a novel site for noncompetitive inhibition
acetylcholine receptors. J Pharmacol Exp Ther, 254: 764–773. of GluN2D-containing NMDA receptors. J Neurosci,
31: 3650–3661.
180. Lodge D, Johnson KM, 1990, Noncompetitive excitatory
amino acid receptor antagonists. Trends Pharmacol Sci, https://doi.org/1523/JNEUROSCI.5565-10.2011
11: 81–86. 191. Costa BM, Irvine MW, Fang G, et al., 2010, A novel family
https://doi.org/1016/0165-6147(90)90323-z of negative and positive allosteric modulators of NMDA
receptors. J Pharmacol Exp Ther, 335: 614–621.
181. Wong EH, Kemp JA, Priestley T, et al., 1986, The
anticonvulsant MK-801 is a potent N-methyl-D-aspartate https://doi.org/1124/jpet.110.174144
antagonist. Proc Natl Acad Sci U S A, 83: 7104–7108. 192. Costa BM, Irvine MW, Fang G, et al., 2012, Structure-activity
https://doi.org/1073/pnas.83.18.7104 relationships for allosteric NMDA receptor inhibitors based
on 2-naphthoic acid. Neuropharmacology, 62: 1730–1736.
182. Carter C, Rivy JP, Scatton B, 1989, Ifenprodil and SL 82.0715
are antagonists at the polyamine site of the N-methyl-D- https://doi.org/1016/j.neuropharm.2011.11.019
aspartate (NMDA) receptor. Eur J Pharmacol, 164: 611–612. 193. Kloda A, Clements JD, Lewis RJ, et al., 2004, Adenosine
https://doi.org/1016/0014-2999(89)90275-6 triphosphate acts as both a competitive antagonist and a
positive allosteric modulator at recombinant N-methyl-D-
183. Karakas E, Simorowski N, Furukawa H, 2011, Subunit aspartate receptors. Mol Pharmacol, 65: 1386–1396.
arrangement and phenylethanolamine binding in GluN1/
GluN2B NMDA receptors. Nature, 475: 249–253. https://doi.org/1124/mol.65.6.1386
https://doi.org/1038/nature10180 194. Williams K, 1994, Subunit-specific potentiation of
recombinant N-methyl-D-aspartate receptors by histamine.
184. Chenard BL, Bordner J, Butler TW, et al., 1995, (1S,2S)-1-
(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)- Mol Pharmacol, 46: 531–541.
1-propanol: A potent new neuroprotectant which 195. Williams K, Zappia AM, Pritchett DB, et al., 1994, Sensitivity
blocks N-methyl-D-aspartate responses. J Med Chem, of the N-methyl-D-aspartate receptor to polyamines is
38: 3138–3145. controlled by NR2 subunits. Mol Pharmacol, 45: 803–809.
https://doi.org/1021/jm00016a017 196. Sedlacek M, Korínek M, Petrovic M, et al., 2008, Neurosteroid
Volume 1 Issue 2 (2022) 23 https://doi.org/10.36922/an.v1i2.148

