Page 27 - AN-1-3
P. 27
Advanced Neurology Early inhibition of PDK1 prevents AD-like pathology
13. Yao YL, Wang YX, Yang FC, et al., 2022, Targeting AKT 27. Lawlor MA, Mora A, Ashby PR, et al., 2002, Essential role
and CK2 represents a novel therapeutic strategy for SMO of PDK1 in regulating cell size and development in mice.
constitutive activation-driven medulloblastoma. CNS EMBO J, 21: 3728–3738.
Neurosci Ther, 28: 1033–1044. 28. Xu C, Yu L, Hou J, et al., 2017, Conditional deletion of PDK1
14. Wang J, Yu Z, Tao Y, et al., 2021, A novel palmitic acid in the forebrain causes neuron loss and increased apoptosis
hydroxy stearic acid (5-PAHSA) plays a neuroprotective during cortical development. Front Cell Neurosci, 11: 330.
role by inhibiting phosphorylation of the m-TOR-ULK1 29. Wei YJ, Han XN, Zhao CJ, 2020, PDK1 regulates the survival
pathway and regulating autophagy. CNS Neurosci Ther, of the developing cortical interneurons. Mol Brain, 13: 65.
27: 484–496.
30. Oakley H, Cole SL, Logan S, et al., 2006, Intraneuronal-
15. Wang H, Liu M, Zou G, et al., 2021, Deletion of PDK1 amyloid aggregates, neurodegeneration, and neuron loss
in oligodendrocyte lineage cells causes white matter in transgenic mice with five familial Alzheimer’s disease
abnormality and myelination defect in the central nervous mutations: Potential factors in amyloid plaque formation.
system. Neurobiol Dis, 148: 105212. J Neurosci, 26: 10129–10140.
16. Wang H, Liu M, Ye Z, et al., 2021, Akt regulates Sox10 31. Liu T, Zhu X, Huang C, et al., 2022, ERK inhibition reduces
expression to control oligodendrocyte differentiation via neuronal death and ameliorates inflammatory responses in
phosphorylating FoxO1. J Neurosci, 41: 8163–8180. forebrain-specific Ppp2cα knockout mice. FASEB J, e222515.
17. Ma Y, Xu X, Li C, et al., 2021, Induced neural progenitor cell- 32. Huang C, Liu T, Wang Q, et al., 2020, Loss of PP2A disrupts
derived extracellular vesicles promote neural progenitor cell the retention of radial glial progenitors in the telencephalic
survival via extracellular signal-regulated kinase pathway. niche to impair the generation for late-born neurons during
CNS Neurosci Ther, 27: 1605–1609. cortical development. Cereb Cortex, 30: 4183–4196.
18. Fedder-Semmes KN, Appel B, 2021, The Akt-mTOR 33. Cheng S, Liu T, Hu, Y, et al., 2019, Conditional inactivation
pathway drives myelin sheath growth by regulating Cap- of Pen-2 in the developing neocortex leads to rapid switch of
dependent translation. J Neurosci, 41: 8532. apical progenitors to basal progenitors. J Neurosci, 39: 2195–
19. Bonet IJ, Khomula EV, Araldi D, et al., 2021, PI3K/AKT 2207.
signaling in high molecular weight hyaluronan (HMWH)- 34. Englund C, Fink A, Lau C, et al., 2005, Pax6, Tbr2, and
induced anti-hyperalgesia and reversal of nociceptor Tbr1 are expressed sequentially by radial glia, intermediate
sensitization. J Neurosci, 41: 8414. progenitor cells, and postmitotic neurons in developing
20. Zhao XF, Liao Y, Alam MM, et al., 2020, Microglial mTOR is neocortex. J Neurosci, 25: 247–251.
neuronal protective and antiepileptogenic in the pilocarpine 35. Wu J, Shao C, Ye X, et al., 2021, In vivo brain imaging of
model of temporal lobe epilepsy. J Neurosci, 40: 7593. amyloid-aggregates in Alzheimer’s disease with a near-
21. Fruman DA, Chiu H, Hopkins BD, et al., 2017, The PI3K infrared fluorescent probe. ACS Sensors, 6: 863–870.
pathway in human disease. Cell, 170: 605–635. 36. Ma X, Wang Y, Hua J, et al., 2020, Abeta-sheet-targeted
22. Pietri M, Dakowski C, Hannaoui S, et al., 2013, PDK1 theranostic agent for diagnosing and preventing aggregation
decreases TACE-mediated alpha-secretase activity and of pathogenic peptides in Alzheimer’s disease. Sci CHINA
promotes disease progression in prion and Alzheimer’s Chem, 63: 73–82.
diseases. Nat Med, 19: 1124–1131. 37. Ye X, Chen L, Wang H, et al., 2022, Genetic inhibition of
23. Pei JJ, Khatoon S, An WL, et al., 2003, Role of protein PDK1 robustly reduces plaque deposition and ameliorates
kinase B in Alzheimer’s neurofibrillary pathology. Acta gliosis in the 5×FAD mouse model of Alzheimer’s disease.
Neuropathol, 105: 381–392. Neuropathol Appl Neurobiol, 48: e12839.
24. Mathys H, Davila-Velderrain J, Peng Z, et al., 2019, Single- 38. Han X, Wei Y, Ba R, et al., 2021, PDK1 regulates the
cell transcriptomic analysis of Alzheimer’s disease. Nature, lengthening of G1 phase to balance RGC proliferation and
570: 332–337. differentiation during cortical neurogenesis. Cereb Cortex,
32: 3488–3500.
25. Yang S, Pascual-Guiral S, Ponce R, et al., 2018, Reducing the
levels of Akt activation by PDK1 knock-in mutation protects 39. Han X, Wei Y, Wu X, et al., 2020, PDK1 regulates transition
neuronal cultures against synthetic smyloid-beta peptides. period of apical progenitors to basal progenitors by controlling
Front Aging Neurosci, 9, 435. asymmetric cell division. Cereb Cortex, 30: 406–420.
26. Stein TD, Johnson, JA, 2002, Lack of neurodegeneration in 40. Wang L, Cheng S, Yin Z, et al., 2015, Conditional inactivation
transgenic mice overexpressing mutant amyloid precursor of Akt three isoforms causes tau hyperphosphorylation in
protein is associated with increased levels of transthyretin the brain. Mol Neurodegener, 10: 33.
and the activation of cell survival pathways. J Neurosci, 41. Li QQ, Chen J, Hu P, et al., 2022, Enhancing GluN2A-
22: 7380. type NMDA receptors impairs long-term synaptic plasticity and
Volume 1 Issue 3 (2022) 11 https://doi.org/10.36922/an.v1i3.153

