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Advanced Neurology BRRS: A screening and monitoring tool for better prognosis in AD

Table 1. Brief Risk Rating Scale.
Name: Sex: Age: Education: Date:
Original score (O) Patient’s score
O 0 O 1 O 2
Basic information Group score:
Age: >65 years (add 100 points).
Gender: Postmenopausal female (add 100 points).
Educational level: <12 years (add 100 points).
Pathology: (1) Detected tau protein in CSF or blood (add 100 points).
Pathology: (2) Detected Aβ in CSF or blood (add 100 points).
AD risk gene: Each gene (add 100 points).
Lifestyle Group score:
Weight: (1) Adult aged <65 years with BMI not maintained between 18.5 and 24.9 kg/m (add 100 points).
2
Weight: (2) Adult aged ≥65 years with a trend of weight loss or too skinny (add 100 points).
History of smoking or living in a smoking environment (add 100 points).
Long-term history of insufficient intake of vitamin C (add 100 points).
Long-term history of insufficient or poor-quality sleep (add 100 points).
Long-term history of frailty (add 100 points).
Long-term history of stress (add 100 points).
Comorbidities Group score:
Diabetes history (add 100 points).
Head trauma history (add 100 points).
Cerebrovascular disease history (add 100 points).
Cardiovascular disease history (i.e., atrial fibrillation, hypertension, orthostatic hypotension, etc.):
Each (add 100 points).
Depression history (add 100 points).
Hyperhomocysteinemia history (add 100 points).
Variation score (V) Patient’s score
V 0 V 1 V 2
Limbic region Group score:
Functional damage (add 100 points).
Structural damage: White matter (add 100 points).
Structural damage: Gray matter (add 100 points).
Compensation appears in function (add 100 points).
Compensation appears in structure (add 100 points).
Decompensation or the previously observed compensation disappears: Each disappearance (add 100 points).
WMH (add 100 points).
Frontal region Group score:
Functional damage (add 100 points).
Structural damage: White matter (add 100 points).
Structural damage: Gray matter (add 100 points).
Compensation appears in function (add 100 points).
Compensation appears in structure (add 100 points).
Decompensation or the previously observed compensation disappears: Each disappearance (add 100 points).
WMH (add 100 points).
(Cont’d...)

Volume 1 Issue 3 (2022) 4 https://doi.org/10.36922/an.v1i3.208