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Advanced Neurology                                 BRRS: A screening and monitoring tool for better prognosis in AD




            Table 1. (Continued).
            Name:             Sex:       Age:       Education:        Date:
             Original score (O)                                                                    Patient’s score
                                                                                                   O 0  O 1  O 2
            Parietal region  Group score:
                             Functional damage (add 100 points).
                             Structural damage: White matter (add 100 points).
                             Structural damage: Gray matter (add 100 points).
                             Compensation appears in function (add 100 points).
                             Compensation appears in structure (add 100 points).
                             Decompensation or the previously observed compensation disappears: Each disappearance (add 100 points).
                             WMH (add 100 points).
            Temporal region  Group score:
                             Functional damage (add 100 points).
                             Structural damage: White matter (add 100 points).
                             Structural damage: Gray matter (add 100 points).
                             Compensation appears in function (add 100 points).
                             Compensation appears in structure (add 100 points).
                             Decompensation or the previously observed compensation disappears: Each disappearance (add 100 points).
                             WMH (add 100 points).
            Occipital region  Group score:
                             Functional damage (add 100 points).
                             Structural damage: White matter (add 100 points).
                             Structural damage: Gray matter (add 100 points).
                             Compensation appears in function (add 100 points).
                             Compensation appears in structure (add 100 points).
                             Decompensation or the previously observed compensation disappears: Each disappearance (add 100 points).
                             WMH (add 100 points).
            Cerebellar region  Group score:
                             Functional damage (add 100 points).
                             Structural damage: White matter (add 100 points).
                             Structural damage: Gray matter (add 100 points).
                             Compensation appears in function (add 100 points).
                             Compensation appears in structure (add 100 points).
                             Decompensation or the previously observed compensation disappears: Each disappearance (add 100 points).
                             WMH (add 100 points).
             Total score                                                                           S   S   S
                                                                                                    0   1   2
            Note
            Aβ, beta-amyloid; BMI, body mass index; CSF, cerebrospinal fluid; WMH, white matter hyperintensity.
            prevention [14,15] . It is divided into three groups: Basic   The last group relates to comorbidities, such as diabetes,
            information, lifestyle, and comorbidities. The basic   head trauma, cerebrovascular disease, cardiovascular
            information group consists of five items, namely, age ,   disease, depression, and hyperhomocysteinemia . Except
                                                        [14]
                                                                                                     [14]
            sex [16-18] , education [14,18,19] , AD pathological biomarkers   for the weight item and items that have not been tested
            detected in blood or cerebrospinal fluid [20-22] , and AD risk   or scored points previously, there are often not too many
            genes [23-25] . The lifestyle group comprises six items that are   changes in the assessment of the original score. With regard
            associated with weight, diet, living environment, and sleep.   to the items that have originally scored points, despite the


            Volume 1 Issue 3 (2022)                         5                       https://doi.org/10.36922/an.v1i3.208
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