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Advanced Neurology

ORIGINAL RESEARCH ARTICLE
Restless legs syndrome in end-stage

renal disease patients on maintenance
hemodialysis: Quality of life and sleep analysis

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3
3
2
Ning Xu , Suzhen Li , Xiaojun Zhang , Yanqiang Wang , and Xiangling Li *
1
1 Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical
University, Weifang, 261053, China
2 Department of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, 261031, China
3 Department of Neurology, Affiliated Hospital of Weifang Medical University, Weifang, 261031, China

Abstract
Vitamin D insufficiency, calcium/phosphate imbalance, iron deficiency, anemia,
pregnancy, and end-stage renal disease (ESRD) are all thought to be involved in the
pathogenesis of restless leg syndrome (RLS). The prevalence of RLS ranging from
6.6% to 83% has been reported in another study. It is one of the illnesses that affect
the quality of life of ESRD patients on maintenance hemodialysis. Unfortunately, RLS
has not received enough recognition and attention, and the underdiagnosed and
undertreated rate can reach more than 10%. This study aimed to look at the sleep
quality and quality of life of people with RLS who were on maintenance hemodialysis.
The present study included 286 individuals on chronic dialysis. The International
Restless Legs Syndrome Study Group Diagnostic Criteria and the International RLS
*Corresponding author: Rating Scale were used as recommendations to diagnose and assess the severity
Xiangling Li
(lixiangling163@163.com) of RLS. The Pittsburgh sleep quality index (PSQI) and the Short Form-36 Health
Survey (SF-36) were employed to evaluate sleep quality and quality of life. All
Citation: Xu N, Li S, Zhang X, patients’ biochemical and demographic data were reviewed, and statistical analyses
et al., 2023, Restless legs syndrome
in end-stage renal disease patients were carried out. In conclusion, there were no statistically significant variations in
on maintenance hemodialysis: demographic information or clinical and laboratory characteristics between RLS
Quality of life and sleep analysis. patients and those who did not have RLS. Specifically, among dialysis patients, those
Adv Neuro, 2(1): 210.
https://doi.org/10.36922/an.210 with RLS had higher PSQI and SF-36 ratings.
Received: September 29, 2022
Accepted: February 7, 2023 Keywords: Restless legs syndrome; End-stage renal disease; Maintenance dialysis; Quality
of life; Quality of sleep
Published Online: February 23,
2023
Copyright: © 2023 Author(s).
This is an Open Access article 1. Introduction
distributed under the terms of the
Creative Commons Attribution Restless legs syndrome (RLS) is a prevalent sensory-motor problem in hemodialysis
License, permitting distribution,
and reproduction in any medium, (HD) patients that causes sleep disruptions, harms the quality of life, and has been
provided the original work is linked to increased morbidity and mortality in patients on maintenance hemodialysis.
properly cited. However, no consistent results have been obtained regarding the relationship of RLS
Publisher’s Note: AccScience with quality of life and sleep quality in patients on maintenance hemodialysis. There was
Publishing remains neutral with an extensive range in the outcomes of prior investigations due to complicated etiology,
regard to jurisdictional claims in
published maps and institutional pathophysiology, reference standards, race, regional disparities, study technique
affiliations. discrepancies, and diversity.

Volume 2 Issue 1 (2023) 1 https://doi.org/10.36922/an.210