Page 62 - AN-2-1

Advanced Neurology Restless legs syndrome in end-stage renal disease patients

Table 4. SF‑36 scores for RLS and non‑RLS patients Acknowledgments
RLS Non‑RLS P‑value None.
Physical component score 42.56±12.91 45.86±16.18 0.2157 Funding
Physical functioning 62.31±18.62 71.14±22.76 0.0192*
Role physical 44.47±24.12 56.76±31.53 0.0179* This work was supported by Yuan Du Scholars and Weifang
Bodily pain 51.43±23.56 64.17±30.49 0.0113* Key Laboratory and Clinical Research Project Program
of Affiliated Hospital of Weifang Medical University
General health 44.83±19.47 48.76±23.49 0.3114 (2021wyfylcyj03).
Mental component score 45.21±11.47 51.65±14.84 0.0090*
Vitality 52.84±19.35 63.87±23.52 0.0050* Conflict of interest
Social functioning 58.17±22.74 62.34±25.81 0.3314E The authors declare that they have no competing interests
Emotion 40.32±32.74 54.65±39.15 0.0270*
Mental health 62.51±16.34 71.32±20.75 0.0101* Author contributions
RLS: Restless legs syndrome; SF-36: Short Form-36. Categorical Conceptualization: Ning Xu
variables are expressed as percentage while continuous variables are Investigation: Xiangling Li, Yanqiang Wang, Suzhen Li,
expressed as mean±standard deviation. *P<0.05. Xiaojun Zhang
Writing – original draft: Ning Xu
Table 5. PSQI scores for RLS and non‑RLS patients Writing – review & editing: Ning Xu
RLS Non‑RLS P‑value All authors have read and approved the final manuscript.
Sleep quality 1.76±0.75 1.43±0.61 0.0049* Ethics approval and consent to participate
Sleep latency 2.18±1.22 1.57±1.18 0.0025*
Sleep duration 1.28±0.87 1.01±0.61 0.0149* The Ethics Committee approved the protocol for the study
Habitual sleep efficiency 1.47±0.72 1.24±0.45 0.0065* of Weifang Medical University’s Affiliated Hospital (wyfy-
2022-ky-183), and all subjects provided informed consent.
Sleep disturbance 2.31±0.85 2.02±0.57 0.0057*
Use of sleep medication 1.28±1.14 1.19±0.92 0.5766 Consent for publication
Daytime dysfunction 1.12±0.93 0.95±0.76 0.2011 Consent was obtained from all the participants.
PSQI global score 9.83±5.15 7.43±4.62 0.0027*
PSQI: Pittsburgh sleep quality index; RLS: restless legs syndrome; Availability of data
SF-36: Short Form-36. Continuous variables are expressed as All data generated or analyzed during this study are
mean±standard deviation. *P<0.05
included in this article. Further enquiries can be directed
to the corresponding author.
Finally, whether additional variables such as weariness,
sadness, patient disease uncertainty, nursing care, social References
and family support, and limited diets impact sleep quality 1. Xiao JP, Zhang GX, Chen L, et al., 2017, Restless legs syndrome
and quality of life remain unknown. in maintenance hemodialysis patients: An epidemiologic

5. Conclusions survey in Hefei. Int Urol Nephrol, 49: 1267–1272.
2. Sahli ZT, Jo J, Mousa SA, et al., 2017, Clinical management
This study found that RLS is a significant symptom of restless legs syndrome in end-stage renal disease patients.
of dialysis patients. Since the intensity of restless legs CNS Spectr, 22:14–21.
symptoms in ESRD patients is linked to lower sleep https://doi.org/10.1017/S109285291600064X
quality, impaired physical functioning and lifestyle
standards, and increased mortality risk, management 3. Li Y, Walters AS, Chiuve SE, et al., 2012, Prospective study
and treatment of this syndrome necessitates a long-term of restless legs syndrome and coronary heart disease among
investment. Furthermore, RLS patients had poor sleep women. Circulation, 126:1689–1694.
quality, particularly in subjective sleep quality, sleep 4. Zhang Y, Zhao JH, Huang D, et al., 2020, Multiple comorbid
latency, sleep duration, sleep efficiency, and daytime sleep disorders adversely affect quality of life in Parkinson’s
dysfunction. Moreover, RLS patients have a lower quality disease patients. NPJ Parkinsons Dis, 6: 25.
of life in terms of physical functioning, role restriction, 5. Vlasie A, Trifu SC, Lupuleac C, et al., 2022, Restless legs
pain, vitality, emotion, and mental health. syndrome: An overview of pathophysiology, comorbidities

Volume 2 Issue 1 (2023) 7 https://doi.org/10.36922/an.210