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Advanced Neurology Woven Endobridge embolization: Indications and innovation

Table 1. (Continued)
Study Title Status Population References
NCT03379714 (Belgium) Mid-term Data Collection of Withdrawn - -
the Treatment of Intracranial
Aneurysms with the WEB
aneurysm Embolization System
NCT04839705 Post Approval Study – Evaluate Not yet recruiting - [72]
(United States) the Long-term Safety and
Effectiveness of the WEB Device
(WEB PAS)
NCT03207087 (China) The WEB-IT China Clinical study Unknown status - [73]
Abbreviations: ACA: Anterior cerebral artery; Acom: Anterior communicating artery; BA: Basilar artery; IA: Intracranial aneurysm; ICA: Internal
carotid artery; MCA: Middle cerebral artery; Pcom: Posterior communicating artery.

Table 2. Summary of completed clinical trials result
Study Title Study type Conditions Interventional Results References
treatment
NCT04621552 Virtual Simulation for Observational Aneurysm; Device: WEB Virtual simulation reduced [64]
(France) Woven EndoBridge intracranial embolization time of intervention;
Device Sizing aneurysm decreased radiation dose,
number of undeployed
devices, and need for
corrective interventions.
NCT01975233 WEB French Observatory Observational Brain aneurysm Device: WEB High rate of complete [65]
(France) of the WEB Aneurysm aneurysms occlusion (51.7%) and
Embolization System embolization adequate occlusion (79.3%)
systems at 1 year.
NCT01778322 WEB Clinical Assessment Observational Intracranial Procedure: 56.1% complete occlusion, [66]
(Denmark France, of Intrasaccular Aneurysm aneurysm Intracranial 29.3% neck remnant, and
Germany, Hungary) Therapy (WEBCAST) aneurysm 14.6% aneurysm remnant
embolization at 6 months.
NCT02687607 Clinical Assessment of Observational Brain aneurysm WEB aneurysm 41.3% complete occlusion [67]
(France) WEB Device in Ruptured embolization and 87% adequate
Aneurysms (CLARYS) system occlusion at 1 year,
effective protection against
rebleeding.
NCT02191618 The WEB-IT Clinical Single group Wide-neck Device: WEB 53.8% complete aneurysm [69]
(Canada, Denmark, Study interventional bifurcation occlusion and 84.6%
Germany, intracranial adequate occlusion.
Hungary, Turkey, aneurysms;
United States) intracranial
aneurysms
Abbreviations: CLARYS: Clinical Assessment of WEB Device in Ruptured Aneurysms; WEBCAST: WEB Clinical Assessment of Intrasaccular
Aneurysm Therapy; WEB: Woven Endobridge device; WEB-IT: Woven Endobridge Intrasaccular Therapy.

in 54.0% of the aneurysms, neck remnant in 26.0%, and system’s safety and effectiveness for treatment of wide-
[23]
an aneurysm remnant in 20.0%. Adequate occlusion was neck bifurcation aneurysms (Table 2) . Mortality
reported in 80.0%. More recently, data have been published remained 0.0% throughout the entire 12-month study
[24]
with a cumulative trial population of WEBCAST and period . In the case-controlled and multicenter study
WEBCAST-2 at 3 years and 5-year analysis that (NCT04621552), investigators compared a virtual
[22]
[21]
shows long-term aneurysm stability and occlusion rate in simulation with conventional sizing to determine the
aneurysms treated with the WEB devices. appropriate WEB device size for an aneurysm. The results
demonstrated fulfillment of the primary outcome measure
The WEB Intrasaccular Therapy (WEB-IT) study by shortening the intervention time, lowering the radiation
(NCT02191618) also aimed to validate further the WEB dose, and lowering the number of WEB devices not

Volume 2 Issue 3 (2023) 4 https://doi.org/10.36922/an.293