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Advanced Neurology The role of gut in multiple sclerosis

Funding encephalomyelitis. Clin Exp Immunol, 162: 1–11.

This study was supported by the National Natural Science https://doi.org/10.1111/j.1365-2249.2010.04143.x
Fund for Excellent Young Scholars (82022019 to C.-J. 7. Cekanaviciute E, Yoo BB, Runia TF, et al., 2017, Gut bacteria
Zhang); Nanjing special fund for Medical Science and from multiple sclerosis patients modulate human T cells and
Technology Development Projects for Distinguished exacerbate symptoms in mouse models. Proc Natl Acad Sci
Young Scholars (JQX19005 to C.-J. Zhang), National U S A, 114: 10713–10718.
Natural Science Foundation of China (81701235 to C.-J. https://doi.org/10.1073/pnas.1711235114
Zhang, 81991514 to C.-J. Zhang); The Fundamental 8. Cantarel BL, Waubant E, Chehoud C, et al., 2015, Gut
Research Funds for the Central Universities the Key microbiota in multiple sclerosis: Possible influence of
Research (021414380446 to C.-J. Zhang). immunomodulators. J Investig Med, 63: 729–734.
Conflict of interest https://doi.org/10.1097/JIM.0000000000000192

The authors declare that they have no competing interests. 9. Tremlett H, Zhu F, Arnold D, et al., 2021, The gut microbiota
in pediatric multiple sclerosis and demyelinating syndromes.
Author contributions Ann Clin Transl Neurol, 8: 2252–2269.

Conceptualization: Yunshu Wang, Yun Xu, Cun-Jin Zhang https://doi.org/10.1002/acn3.51476
Writing – original draft: Yunshu Wang, Zihao Li, Cun-Jin 10. Cosorich I, Dalla-Costa G, Sorini C, et al., 2017, High
Zhang frequency of intestinal T 17 cells correlates with microbiota
H
Writing – review & editing: Cun-Jin Zhang. alterations and disease activity in multiple sclerosis. Sci Adv,
3: e1700492.
Ethics approval and consent to participate https://doi.org/10.1126/sciadv.1700492

Not applicable. 11. Miyake S, Kim S, Suda W, et al., 2015, Dysbiosis in the gut
microbiota of patients with multiple sclerosis, with a striking
Consent for publication depletion of species belonging to clostridia XIVa and IV
Not applicable. clusters. PLoS One, 10: e0137429.
https://doi.org/10.1371/journal.pone.0137429
Availability of data
12. Zeng Q, Gong J, Liu X, et al, 2019, Gut dysbiosis and lack of
Not applicable. short chain fatty acids in a Chinese cohort of patients with
multiple sclerosis. Neurochem Int, 129: 104468.
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