Page 30 - AN-2-3
P. 30
Advanced Neurology The role of gut in multiple sclerosis
80. Tankou SK, Regev K, Healy BC, et al., 2018. A probiotic modulate ongoing autoimmune neurological disease.
modulates the microbiome and immunity in multiple J Neuroinflammation, 17: 79.
sclerosis. Ann Neurol, 83: 1147–1161.
https://doi.org/10.1186/s12974-020-01766-9
https://doi.org/10.1002/ana.25244
90. Chen H, Ma X, Liu Y, et al., 2019, Gut microbiota
81. Abdurasulova IN, Matsulevich AV, Tarasova EA, et al., interventions with Clostridium butyricum and norfloxacin
2016, Enterococcus faecium strain L-3 and glatiramer acetate modulate immune response in experimental autoimmune
ameliorate experimental allergic encephalomyelitis in rats encephalomyelitis mice. Front Immunol, 10: 1662.
by affecting different populations of immune cells. Benef https://doi.org/10.3389/fimmu.2019.01662
Microbes, 7: 719–729.
91. Minagar A, Alexander JS, Schwendimann RN, et al.,
https://doi.org/10.3920/BM2016.0018 2008, Combination therapy with interferon beta-1a and
82. Secher T, Kassem S, Benamar M, et al., 2017, Oral doxycycline in multiple sclerosis: An open-label trial. Arch
administration of the probiotic strain Escherichia coli Nissle Neurol, 65: 199–204.
1917 reduces susceptibility to neuroinflammation and repairs https://doi.org/10.1001/archneurol.2007.41
experimental autoimmune encephalomyelitis-induced
intestinal barrier dysfunction. Front Immunol, 8: 1096. 92. Mazdeh M, Mobaien AR, 2012, Efficacy of doxycycline
as add-on to interferon beta-1a in treatment of multiple
https://doi.org/10.3389/fimmu.2017.01096 sclerosis. Iran J Neurol, 11: 70–73.
83. He B, Hoang TK, Tian X, et al., 2019, Lactobacillus 93. Metz LM, Eliasziw M, 2017, Trial of minocycline in
reuteri reduces the severity of experimental autoimmune clinically isolated syndrome of multiple sclerosis. N Engl J
encephalomyelitis in mice by modulating gut microbiota. Med, 377: 789.
Front Immunol, 10: 385.
https://doi.org/10.1056/NEJMc1708486
https://doi.org/10.3389/fimmu.2019.00385
94. Ross CL, Spinler JK, Savidge TC, 2016, Structural and
84. Kouchaki E, Tamtaji OR, Salami M, et al., 2017, Clinical and functional changes within the gut microbiota and
metabolic response to probiotic supplementation in patients susceptibility to Clostridium difficile infection. Anaerobe,
with multiple sclerosis: A randomized, double-blind, 41: 37–43.
placebo-controlled trial. Clin Nutr, 36: 1245–1249.
https://doi.org/10.1016/j.anaerobe.2016.05.006
https://doi.org/10.1016/j.clnu.2016.08.015
95. Zmora N, Suez J, Elinav E, 2019, You are what you eat:
85. Tamtaji OR, Kouchaki E, Salami M, et al., 2017, The effects Diet, health and the gut microbiota. Nat Rev Gastroenterol
of probiotic supplementation on gene expression related to Hepatol, 16: 35–56.
inflammation, insulin, and lipids in patients with multiple
sclerosis: A randomized, double-blind, placebo-controlled https://doi.org/10.1038/s41575-018-0061-2
trial. J Am Coll Nutr, 36: 660–665. 96. Sonnenburg ED, Smits SA, Tikhonov M, et al., 2016, Diet-
https://doi.org/10.1080/07315724.2017.1347074 induced extinctions in the gut microbiota compound over
generations. Nature, 529: 212–215.
86. Miyauchi E, Kim SW, Suda W, et al., 2020, Gut
microorganisms act together to exacerbate inflammation in https://doi.org/10.1038/nature16504
spinal cords. Nature, 585: 102–106. 97. Sonnenburg JL, Backhed F, 2016, Diet-microbiota
https://doi.org/10.1038/s41586-020-2634-9 interactions as moderators of human metabolism. Nature,
535: 56–64.
87. Montgomery TL, Künstner A, Kennedy JJ, et al., 2020,
Interactions between host genetics and gut microbiota https://doi.org/10.1038/nature18846
determine susceptibility to CNS autoimmunity. Proc Natl 98. Kap YS, Bus-Spoor C, van Driel N, et al., 2018, Targeted diet
Acad Sci U S A, 117: 27516–27527. modification reduces multiple sclerosis-like disease in adult
https://doi.org/10.1073/pnas.2002817117 marmoset monkeys from an outbred colony. J Immunol,
201: 3229–3243.
88. Mestre L, Carrillo-Salinas FJ, Mecha M, et al., 2019,
Manipulation of gut microbiota influences immune https://doi.org/10.4049/jimmunol.1800822
responses, axon preservation, and motor disability in a 99. Cignarella F, Cantoni C, Ghezzi L, et al., 2018, Intermittent
model of progressive multiple sclerosis. Front Immunol, fasting confers protection in CNS autoimmunity by altering
10: 1374. the gut microbiota. Cell Metab, 27: 1222–1235.e6.
https://doi.org/10.3389/fimmu.2019.01374 https://doi.org/10.1016/j.cmet.2018.05.006
89. Gödel C, Kunkel B, Kashani A, et al., 2020, Perturbation 100. Saresella M, Mendozzi L, Rossi V, et al., 2017, Immunological
of gut microbiota decreases susceptibility but does not and clinical effect of diet modulation of the gut microbiome in
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