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Advanced Neurology SARS-CoV-2 in age-associated neurodegeneration

2018;92:e00404-18. doi: 10.1074/jbc.M109.008227
doi: 10.1128/JVI.00404-18 74. Zheng Y, Zhuang MW, Han L, et al. Severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) membrane (M)
64. Vakili K, Fathi M, Yaghoobpoor S, et al. The contribution of protein inhibits type I and III interferon production by
gut-brain axis to development of neurological symptoms in targeting RIG-I/MDA-5 signaling. Signal Transduct Target
COVID-19 recovered patients: A hypothesis and review of Ther. 2020;5(1):299.
literature. Front Cell Infect Microbiol. 2022;12:983089.
doi: 10.1038/s41392-020-00438-7
doi: 10.3389/fcimb.2022.983089
75. Cicaloni V, Costanti F, Pasqui A, Bianchini M, Niccolai N,
65. Winston CN, Goetzl EJ, Akers JC, et al. Prediction of Bongini P. A bioinformatics approach to investigate structural
conversion from mild cognitive impairment to dementia and non-structural proteins in human coronaviruses. Front
with neuronally derived blood exosome protein profile. Genet. 2022;13:891418.
Alzheimers Dement. 2016;3:63-72.
doi: 10.3389/fgene.2022.891418
doi: 10.1016/j.dadm.2016.04.001
76. Kehrer T, Cupic A, Ye C, et al. Impact of SARS-CoV-2 ORF6
66. Strong MJ. SARS-CoV-2, aging, and Post-COVID-19 and its variant polymorphisms on host responses and viral
neurodegeneration. J Neurochem. 2023;165(2):115-130. pathogenesis. Cell Host Microbe. 2023;31(10):1668-1684.e12.
doi: 10.1111/jnc.15736 doi: 10.1016/j.chom.2023.08.003
67. Ahmed SSSJ, Paramasivam P, Kamath M, Sharma A, Rome S, 77. O’Driscoll M, Ribeiro Dos Santos G, Wang L, et al.
Murugesan R. Genetic exchange of lung-derived exosome Age-specific mortality and immunity patterns of
to brain causing neuronal changes on COVID-19 infection. SARS-CoV-2. Nature. 2021;590(7844):140-145.
Mol Neurobiol. 2021;58(10):5356-5368.
doi: 10.1038/s41586-020-2918-0
doi: 10.1007/s12035-021-02485-9
78. Mavrikaki M, Lee JD, Solomon IH, Slack FJ. Severe
68. Sergio MC, Ricciardi S, Guarino AM, Giaquinto L, De COVID-19 is associated with molecular signatures of aging
Matteis MA. Membrane remodeling and trafficking piloted in the human brain. Nat Aging. 2022;2(12):1130-1137.
by SARS-CoV-2. Trends Cell Biol. 2024;4:1531-1555.
doi: 10.1038/s43587-022-00321-w
doi: 10.1016/j.tcb.2023.12.006
79. Silva J, Patricio F, Patricio-Martínez A, et al.
69. Wang M, Zhao Y, Liu J, Li T. SARS-CoV-2 modulation Neuropathological aspects of SARS-CoV-2 infection:
of RIG-I-MAVS signaling: Potential mechanisms of Significance for both Alzheimer’s and Parkinson’s disease.
impairment on host antiviral immunity and therapeutic Front Neurosci. 2022;16:867825.
approaches. MedComm Futur Med. 2022;1(2):e29.
doi: 10.3389/fnins.2022.867825
doi: 10.1002/mef2.29
80. Cao X, Li W, Wang T, et al. Accelerated biological aging in
70. Chen Y, Cai H, An Pan J’, et al. Functional screen reveals COVID-19 patients. Nat Commun. 2022;13(1):2135.
SARS coronavirus nonstructural protein Nsp14 as a novel
Cap N7 methyltransferase. Proc Natl Acad Sci U S A. doi: 10.1038/s41467-022-29801-8
2009;106:3484-3489. 81. Lee B, Choi HN, Che YH, et al. SARS-CoV-2 infection
doi: 10.1073/pnas.0808790106 exacerbates the cellular pathology of Parkinson’s disease in
human dopaminergic neurons and a mouse model. Cell Rep
71. Wilamowski M, Sherrell DA, Minasov G, et al. 2′-O Med. 2024;5(5):101570.
methylation of RNA cap in SARS-CoV-2 captured
by serial crystallography. Proc Natl Acad Sci U S A. doi: 10.1016/j.xcrm.2024.101570
2021;118:e2100170118. 82. Huang P, Zhang LY, Tan YY, Chen SD. Links between
doi: 10.1073/pnas.2100170118/-/DCSupplemental COVID-19 and Parkinson’s disease/Alzheimer’s disease:
Reciprocal impacts, medical care strategies and underlying
72. Chang LJ, Chen TH. Nsp16 2′-o-mtase in coronavirus mechanisms. Transl Neurodegener. 2023;12(1):5.
pathogenesis: Possible prevention and treatments strategies.
Viruses. 2021;13(4):538. doi: 10.1186/s40035-023-00337-1
doi: 10.3390/v13040538 83. Emrani S, Arain HA, DeMarshall C, Nuriel T. APOE4 is
associated with cognitive and pathological heterogeneity
73. Siu KL, Kok KH, Ng MHJ, et al. Severe acute respiratory in patients with Alzheimer’s disease: A systematic review.
syndrome coronavirus M protein inhibits type I Alzheimers Res Ther. 2020;12(1):141.
interferon production by impeding theformation of
TRAF3·TANK·TBK1/IKKε complex. J Biol Chem. doi: 10.1186/s13195-020-00712-4
2009;284(24):16202-16209. 84. Kuo CL, Pilling LC, Atkins JL, et al. APOE e4 genotype

Volume 3 Issue 4 (2024) 22 doi: 10.36922/an.4267