Page 97 - AN-3-4

Advanced Neurology SARS-CoV-2 in age-associated neurodegeneration

106. Carpenè G, Onorato D, Nocini R, et al. Blood lactate disease. Front Neurosci. 2023;17:1268419.
concentration in COVID-19: A systematic literature review. doi: 10.3389/fnins.2023.1268419
Clin Chem Lab Med. 2022;60(3):332-337.
118. Vuille-dit-Bille RN, Liechty KW, Verrey F, Guglielmetti LC.
doi: 10.1515/cclm-2021-1115
SARS-CoV-2 receptor ACE2 gene expression in
107. Noonong K, Chatatikun M, Surinkaew S, et al. Mitochondrial small intestine correlates with age. Amino Acids.
oxidative stress, mitochondrial ROS storms in long COVID 2020;52(6-7):1063-1065.
pathogenesis. Front Immunol. 2023;14:1275001.
doi: 10.1007/s00726-020-02870-z
doi: 10.3389/fimmu.2023.1275001
119. Zhang Y, Yan R, Zhou Q. ACE2, B0AT1, and SARS-CoV-2
108. Sindona C, Schepici G, Contestabile V, Bramanti P, spike protein: Structural and functional implications. Curr
Mazzon E. NOX2 activation in Covid-19: Possible Opin Struct Biol. 2022;74:102388.
implications for neurodegenerative diseases. Medicina
(Lithuania). 2021;57(6):604. doi: 10.1016/j.sbi.2022.102388
doi: 10.3390/medicina57060604 120. Abu-Eid R, Ward FJ. Targeting the PI3K/Akt/mTOR
pathway: A therapeutic strategy in COVID-19 patients.
109. Montezano AC, Camargo LL, Mary S, et al. SARS-CoV-2 Immunol Lett. 2021;240:1-8.
spike protein induces endothelial inflammation via ACE2
independently of viral replication. Sci Rep. 2023;13(1):14086. doi: 10.1016/j.imlet.2021.09.005
doi: 10.1038/s41598-023-41115-3 121. Ghazanfar H, Kandhi S, Shin D, et al. Impact of COVID-19
on the gastrointestinal tract: A clinical review. Cureus.
110. Liochev SI. Reactive oxygen species and the free radical 2022;14:e23333.
theory of aging. Free Radic Biol Med. 2013;60:1-4.
doi: 10.7759/cureus.23333
doi: 10.1016/j.freeradbiomed.2013.02.011
122. Yamamoto S, Saito M, Tamura A, Prawisuda D, Mizutani T,
111. Xue M, Feng L. The role of unfolded protein response in Yotsuyanagi H. The human microbiome and COVID-19:
coronavirus infection and its implications for drug design. A systematic review. PLoS One. 2021;16(6):e0253293.
Front Microbiol. 2021;12:808593.
doi: 10.1371/journal.pone.0253293
doi: 10.3389/fmicb.2021.808593
123. Huang X, Hussain B, Chang J. Peripheral inflammation and
112. Wang X, Wang W, Wang T, et al. SARS-CoV-2 ORF8 protein blood–brain barrier disruption: Effects and mechanisms.
induces endoplasmic reticulum stress-like responses and
facilitates virus replication by triggering calnexin: An CNS Neurosci Ther. 2021;27(1):36-47.
unbiased study. J Virol. 2023;97(3):e0001123. doi: 10.1111/cns.13569
doi: 10.1128/jvi.00011-23 124. Sencio V, Machado MG, Trottein F. The lung-gut axis during
viral respiratory infections: The impact of gut dysbiosis
113. Kohli E, Causse S, Baverel V, et al. Endoplasmic reticulum
chaperones in viral infection: Therapeutic perspectives. on secondary disease outcomes. Mucosal Immunol.
Microbiol Mol Biol Rev. 2021;85:e0003521. 2021;14(2):296-304.
doi: 10.1128/MMBR.00035-21 doi: 10.1038/s41385-020-00361-8
114. Wang M, Zhang Y, Li C, Chang W, Zhang L. The relationship 125. Rodrigues L, Cunha RB, Vassilevskaia T, Viveiros M,
between gut microbiota and COVID-19 progression: New Cunha C. Drug repurposing for COVID-19: A review and
insights into immunopathogenesis and treatment. Front a novel strategy to identify new targets and potential drug
Immunol. 2023;14:1180336. candidates. Molecules. 2022;27(9):2723.
doi: 10.3389/fimmu.2023.1180336 doi: 10.3390/molecules27092723
115. Wong AC, Devason AS, Umana IC, et al. Serotonin 126. Hashemian SMR, Pourhanifeh MH, Hamblin MR,
reduction in post-acute sequelae of viral infection. Cell. Shahrzad MK, Mirzaei H. RdRp inhibitors and COVID-19:
2023;186(22):4851-4867.e20. Is molnupiravir a good option? Biomedicine and
Pharmacotherapy. 2022;146:112517.
doi: 10.1016/j.cell.2023.09.013
doi: 10.1016/j.biopha.2021.112517
116. Carabotti M, Scirocco A, Antonietta Maselli M, Severi C.
The gut-brain axis: Interactions between enteric microbiota, 127. Malone B, Urakova N, Snijder EJ, Campbell EA. Structures
central and enteric nervous systems. Ann Gastroenterol. and functions of coronavirus replication-transcription
2015;28:203-209. complexes and their relevance for SARS-CoV-2 drug design.
Nat Rev Mol Cell Biol. 2022;23(1):21-39.
117. Denman CR, Park SM, Jo J. Gut-brain axis: Gut dysbiosis
and psychiatric disorders in Alzheimer’s and Parkinson’s doi: 10.1038/s41580-021-00432-z

Volume 3 Issue 4 (2024) 24 doi: 10.36922/an.4267