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Advanced Neurology Brain bioavailability of targeted protein degraders

References 5 6 83 83 84 (Contd...)

Structure

E3 ligase ligand CRBN VHL CRBN CRBN VHL
Table 2. Targeted protein degraders under development for central nervous system indications

Targeted protein Tau Tau Tau Tau Tau

Development stage Preclinical Preclinical Preclinical Preclinical Preclinical

Frontotemporal dementia; tauopathies Alzheimer’s disease; tau-related diseases Frontotemporal dementia; tauopathies Frontotemporal dementia; tauopathies Alzheimer’s disease; tauopathies

Indication

QC-01-175 C004019 (240) FMF-06-038 FMF-06-049
TPD TH006

Volume 4 Issue 2 (2025) 61 doi: 10.36922/an.5140