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Advanced Neurology Depression and its risk factors in India

Table 2. (Continued)
No. Gene SNPs Tool (s) Case group/ Location Type of Relationship Results Author and
control study year
group
9 SLC1A3 C3590T, C869G, CES-D 108/205 Uttar Pradesh RA ✓ SLC1A3 C35A90T was Ghosh et al.,
and BDNF and G196A a predisposition factor 2020 13
for stress and depression
in an Eastern Indian
population, whereas
SLC1A3 G869C and
BDNF G196A were not.
10 MTR A2756G BDI-II 808/None New Delhi RA ✓ Only the MTR A2756G Dahal et al.,
A66G X gene polymorphism was 2022 98
significantly associated
11 CBS 844ins68 X with mild depression,
but not moderate or
severe depression.
12 MTHFR C677T BDI-II 271/557 Haryana RA X The MTHFR C677T gene Kaur et al.,
polymorphism was not 2021 99
associated with depression
in the present study.
13 MTHFR C677T PHQ-9 93/210 New Delhi RA X The T allele of the Saraswathy
MTHFR C677T gene et al., 2019 100
polymorphism was
associated with an
increased risk of
depression and anxiety
disorder, although this
was not significant.
14 DAT TaqA1 GDS 30/30 Lucknow RA X No significant Mahdi et al.,
VNTR X association was observed 2022 101
for either variant.
15 LEP D7S1875 None 133/136 Rajasthan RA ✓ LEP gene variants may Kapoor et al.,
be related to depression 2009 168
and associated
comorbidities like
hypertension
16 TPH A779C DSM-IV TR 140/160 Kashmir RA ✓ The TPH 1 A779C A Mushtaq
gene was found to be et al., 2016 169
associated with MDD in
the Kashmiri population.
17 SLC6A4 5-HTTLPR- HDRS-17; 148/None Karnataka DR ✓ Results suggest that Mandal et al.,
MADRS; CGI 5HTTLPR and rs-25531 2020 170
polymorphisms can
influence escitalopram
treatment response in
depressive patients in a
South Indian population,
with LL genotypes and
LALA haplotypes being
the predictors of better
treatment response.
18 VDBP rs7041 EPDS 330/330 Puducherry RA ✓ Rs4588 and rs7041 Pillai et al.,
rs4588 ✓ were associated with 2022 171
lower circulating
serum vitamin D levels,
which may lead to PPD
susceptibility.
(Cont’d...)

Volume 4 Issue 3 (2025) 36 doi: 10.36922/an.5940