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Advanced Neurology Cytokine response to EV therapy in SCI

Methodology: Yana O. Mukhamedshina, Ilyas M. Kabdesh angiogenesis after spinal cord injury in rats. J Neurotrauma.
Project administration: Yana O. Mukhamedshina, Albert A. 2017;34(24):3388-3396.
Rizvanov doi: 10.1089/neu.2017.5063
Software: Albert A. Rizvanov
Resources: Yana O. Mukhamedshina, Albert A. Rizvanov 5. Romanelli P, Bieler L, Scharler C, et al. Extracellular vesicles
can deliver anti-inflammatory and anti-scarring activities
Supervision: Yana O. Mukhamedshina of mesenchymal stromal cells after spinal cord injury. Front
Validation: Ekaterina E. Garanina, Yana O. Neurol. 2019;10:1225.
Mukhamedshina, Ilyas M. Kabdesh
Visualization: Ilyas M. Kabdesh doi: 10.3389/fneur.2019.01225
Writing–original draft: Yana O. Mukhamedshina, 6. Romanelli P, Bieler L, Heimel P, et al. Enhancing functional
Alexander A. Kostennikov, Ilyas M. Kabdesh recovery through intralesional application of extracellular
Writing–review & editing: Yana O. Mukhamedshina, Ilyas vesicles in a rat model of traumatic spinal cord injury. Front
M. Kabdesh Cell Neurosci. 2022;15:795008.
doi: 10.3389/fncel.2021.795008
Ethics approval and consent to participate
7. Levi AD, Okonkwo DO, Park P, et al. Emerging safety of
The methods described herein were performed in intramedullary transplantation of human neural stem cells
accordance with the Declaration of Helsinki and approved in chronic cervical and thoracic spinal cord injury. Clin
by the local ethical committee of Kazan (Volga region) Neurosurg. 2018;82(4):562-575.
Federal University (No. 2, May 5, 2015). doi: 10.1093/neuros/nyx250

Consent for publication 8. Murphy KC, Whitehead J, Zhou D, Ho SS, Leach JK.
Engineering fibrin hydrogels to promote the wound
Not applicable. healing potential of mesenchymal stem cell spheroids. Acta
Biomater. 2017;64:176-186.
Availability of data
doi: 10.1016/j.actbio.2017.10.007
Data are available from the corresponding author upon 9. Mukhamedshina YO, Akhmetzyanova ER, Kostennikov AA,
reasonable request. et al. Adipose-derived mesenchymal stem cell application
combined with fibrin matrix promotes structural and
Further disclosure functional recovery following spinal cord injury in rats.
The paper has been uploaded to a preprint server (bioRxiv, Front Pharmacol. 2018;9:343.
doi: 10.1101/2024.10.07.616981). doi: 10.3389/fphar.2018.00343
References 10. Mukhamedshina Y, Shulman I, Ogurcov S, et al.
Mesenchymal stem cell therapy for spinal cord contusion:
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11. Ragni E, De Luca P, Landoni S, et al. High efficiency protocol
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for platelet derived fibrin gel loaded with mesenchymal stromal
2. Sabirov D, Ogurcov S, Shulman I, et al. Comparative analysis cells extracellular vesicles. Regen Ther. 2024;26:442-457.
of cytokine profiles in cerebrospinal fluid and blood serum
in patients with acute and subacute spinal cord injury. doi: 10.1016/j.reth.2024.06.020
Biomedicines. 2023;11(10):2641. 12. Kostennikov A, Kabdesh I, Sabirov D, et al. A comparative
study of mesenchymal stem cell-derived extracellular
doi: 10.3390/biomedicines11102641
vesicles’ local and systemic dose-dependent administration
3. Zhou X, Chu X, Yuan H, et al. Mesenchymal stem cell in rat spinal cord injury. Biology (Basel). 2022;11(12):1853.
derived EVs mediate neuroprotection after spinal cord
injury in rats via the microRNA-21-5p/FasL gene axis. doi: 10.3390/biology11121853
Biomed Pharmacother. 2019;115:108818. 13. Allison DJ, Ditor DS. Immune dysfunction and chronic
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