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Brain & Heart Cerebral venous thrombosis mimicking brain tumors

Table 3. Role of nine differentially expressed genes in
cerebral venous thrombosis mimicking brain tumor
Q‑value 5.17005E-06 2.27553E-05 0.000133801 0.000442469 0.005510118 0.006748326 0.020902556 0.024538326 0.048398952 Gene name Description Function

SERPINE1 Serpin family E member 1 Procoagulant [36]
Procoagulant
Selectin P
SELP
[32,37]
P‑value 2.58404E-09 3.07748E-08 3.41029E-07 2.2115E-06 7.35482E-05 9.76149E-05 0.000455682 0.000570659 0.001501439 THBD Thrombomodulin Anticoagulant [39]
[38]
Procoagulant
Integrin subunit beta 3
ITGB3
TFPI Tissue factor pathway inhibitor Anticoagulant [35]
[40,41]
FC 352.8751368 27.92495 31.84366175 34.14724589 8.591435853 12.33398636 4.294925185 57.01516573 4.705337837 F13A1 Coagulation factor XIII A chain Procoagulant [43,44]
Protein S
PROS1
Anticoagulant
[42]
Procoagulant
PPBP
Pro-platelet basic protein
PROCR Protein C receptor Procoagulant [45,46]
N‑4 0.181902 0 0.375565 0.27465 1.05931 0.512676 1.44264 0.184277 1.3534 All our patients had remarkable routine blood and
coagulation dysfunctions. D-dimer is considered a highly
N‑3 0.14045 0 0.77242 0.514465 0.644038 4.75645 2.69163 0 1.16286 sensitive and specific laboratory screening indicator, but its
normal value is not an obviating standard
. Five of nine
[15,26]
patients from the previous studies have shown normal
N‑2 0.76462 0 0.259109 0.027796 2.21498 0.482464 2.04695 0 1.72016 routine blood and coagulation function [7,11,13-15] . However,
the combination of D-dimer value and risk factors can
still be helpful to predict thrombosis . Studies are now
[26]
N‑1 0.413546 0 0.772478 0.540819 0.831571 0.161204 2.52432 0.62949 2.94748 focusing on biomarkers associated with cerebral venous
infarction. Serum high-sensitivity C-reactive protein level
is considered an essential indicator associated with the
[27]
Table 2. Expression levels of differentially expressed genes related to thrombophilia
C‑4 5.22394 0.239218 3.36236 3.65576 1.78063 6.11608 3.01435 30.4097 3.7969 severity of CVT in acute/subacute phase .
An early use of heparin may exert better effect, but its
spontaneous agreeable change cannot be ignored . Harada
[28]
C‑3 56.1023 0.369313 7.93675 6.2385 17.1041 18.4394 15.6811 0.097438 8.25014 et al. have reported a case of a patient with venous infarction
mimicking low-grade glioma resolving spontaneously
without invasive operation . In the previous reports, most
[29]
patients were suspected with glioma and underwent excisional
479.993 0.197471 57.5268 36.6532 18.1522 10.5174 11.377 17.5531 17.7491 biopsy. All our patients underwent excisional biopsy and their
C‑2 histopathological results revealed abundant small vascular
obstruction, inflammatory cell infiltration, and regional
2.25126 0.270996 1.81339 1.14117 4.07518 38.3088 7.44899 0.577429 4.15475 hemorrhage. We observed focal hemorrhage surrounding
C‑1 the vein in four of the five lesions, which is consistent with
the findings of previous studies. Juxtacortical hemorrhage
can thus be an important diagnostic indication [5,28] .
Due to the rarity of CVT, few studies have focused on
Gene name SERPINE1 SELP THBD ITGB3 TFPI F13A1 PROS1 PPBP PROCR the gene expression changes in patients with CVTMBT. To
identify the key genes associated with the pathogenesis of
CVTMBT, mRNA sequencing was performed on specimens
between patients with CVTMBT and non-CVTMBT at
our hospital. Nine filtered genes were considered to be
ENSG00000106366 ENSG00000174175 ENSG00000178726 ENSG00000259207 ENSG00000003436 ENSG00000124491 ENSG00000184500 ENSG00000163736 ENSG00000101000 closely related to protein S deficiency induced through
significantly related to CVT. Unexplained thrombosis is
a new mutation Gly222Arg in PROS1 . The SERPINE1
[30]
Gene ID gene has shown an increased risk of arterial and venous
thromboses . In general, SELP, SERPINE1, PROCR,
[31]

Volume 1 Issue 1 (2023) 7 https://doi.org/10.36922/bh.v1i1.188