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Brain & Heart Cerebral venous thrombosis mimicking brain tumors

Figure 6. A flowchart for diagnosing CVTMBT. Non-specific primary imaging findings, including enhancement and mass effect, accompanied by
intracranial hypertension and similar neurological deficits, were the main reasons for clinical misdiagnosis. However, various predisposing factors of
CVT, shorter disease course, and coagulation dysfunction observed in patients may aid in differentiating CVTMBT from brain tumors. In cases where
establishing the initial diagnosis is difficult, biopsy is performed. The effectiveness of anticoagulation therapy confirms the diagnosis of CVTMBT.
MRI: Magnetic resonance imaging; NSAIDs: Non-steroidal anti-inflammatory drugs; CVT: Cerebral venous thrombosis; CVTMBT: Cerebral venous
thrombosis mimicking brain tumor

PPBP, and F13A1 play a critical role in thrombosis [32-35] , cells is the most pathogenic finding. Anticoagulation
whereas a deficiency of PROS1, THBD, and TFPI increases therapy is effective in treating CVTMBT. Furthermore, the
the risk of thrombosis [36-38] . The potential mechanism of nine key genes identified in the pathogenesis of CVTMBT
coagulation and anti-coagulation following CVTMBT may be potential biomarkers for accurate screening and
remains unclear. The role of these thrombophilia-related appropriate treatment for CVT.
DEGs in CVTMBT requires further studies.

There are several limitations to the present study. Acknowledgments
First, the study sample was small; hence, studies with None.
larger sample sizes with long-term clinical observations
for further statistical analyses are required in the future. Funding
Second, the potential interaction mechanism among the This work was supported by the National Key Research
filtered genes was not fully elucidated in the present study and Development Program of China (2021YFE0204700)
and thus warrants further investigation. and Provincial and ministerial co-construction project of
Henan Medical Science and Technology Research Plan
5. Conclusions (SB201901007).
CVTMBT presents with enhancement and mass effect
on MRI, accompanied by various predisposing factors, Conflict of interest
shorter disease duration, and coagulation dysfunction. The authors declare that they have no known competing
Obstructed vein can be found intraoperatively and financial interests or personal relationships that could have
thrombosed vein infiltrated by excessive inflammatory appeared to influence the work reported in this paper.

Volume 1 Issue 1 (2023) 8 https://doi.org/10.36922/bh.v1i1.188