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Brain & Heart Autonomic nerve and heart failure

prevention and treatment strategies of cardiac remodeling Circulation, 131: 1435–1447.
and heart failure using non-drug approaches, however, https://doi.org/10.1161/CIRCULATIONAHA.115.013894
remain a research hotspot and an urgent scientific problem
to be solved in this field, which has a wide range of potential 5. Floras JS, 2009, Sympathetic nervous system activation in
human heart failure: Clinical implications of an updated
applications.
model. J Am Coll Cardiol, 54: 375–385.
Acknowledgments https://doi.org/10.1016/j.jacc.2009.03.061
None. 6. Florea VG, Cohn JN, 2014, The autonomic nervous system
and heart failure. Circ Res, 114: 815–1826.
Funding https://doi.org/10.1161/CIRCRESAHA.114.302589
The funding for this research was provided by the National 7. Floras JS, Ponikowski P, 2015, The sympathetic/
Natural Science Foundation of China, grant number parasympathetic imbalance in heart failure with reduced
82070425, awarded to Zhibing Lu, and the Natural Science ejection fraction. Eur Heart J, 36: 1974–1982b.
Foundation of Hubei Province of China, grant number https://doi.org/10.1093/eurheartj/ehv087
2021CFA011, also awarded to Zhibing Lu.
8. Armour JA, 2004, Cardiac neuronal hierarchy in health
Conflict of interest and disease. Am J Physiol Regul Integr Comp Physiol, 287:
R262–R271.
The authors declare that they have no competing interest.
https://doi.org/10.1152/ajpregu.00183.2004
Author contributions 9. Kember G, Armour JA, Zamir M, 2011, Neural control of
heart rate: The role of neuronal networking. J Theor Biol,
Investigation: Hanyu Zhang, Yanfang Zhu, Siyu Chen 277: 41–47.
Methodology: Keqiong Deng, Meng Zheng
Formal analysis: Ziyue Zeng, Qiongxin Wang https://doi.org/10.1016/j.jtbi.2011.02.013
Writing – original draft: Hanyu Zhang 10. Armour JA, 2008, Potential clinical relevance of the “little
Writing – review & editing: Zhibing Lu, Huanhuan Cai brain” on the mammalian heart. Exp Physiol, 93: 165–176.
All authors have read and approved the final manuscript. https://10.1113/expphysiol.2007.041178
Ethics approval and consent to participate 11. Ardell JL, Armour JA, 2016, Neurocardiology: Structure-
based function. Compr Physiol, 6: 1635–1653.
Not applicable.
https://doi.org/10.1002/cphy.c150046
Consent for publication 12. Jaenig W, 2016, Neurocardiology: A neurobiologist’s
Not applicable. perspective. J Physiol, 594: 3955–3962.
https://doi.org/10.1113/JP271895
Availability of data
13. Shivkumar K, Ajijola OA, Anand I, et al., 2016, Clinical
Not applicable. neurocardiology defining the value of neuroscience-based
cardiovascular therapeutics. J Physiol, 594: 3911–3954.
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