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Brain & Heart Human DPSCs attenuated amyotrophic lateral sclerosis in mice

indirectly. Separately, other authors declared that they 4. Brown RH, Al-Chalabi A. Amyotrophic lateral sclerosis.
have no known competing financial interests or personal N Engl J Med. 2017;377(2):162-172.
relationships that could have influenced the work reported doi: 10.1056/NEJMra1603471
in this paper.
5. Batagov AO, Kurochkin IV. Exosomes secreted by human
Author contributions cells transport largely mRNA fragments that are enriched in
the 3’-untranslated regions. Biology Direct. 2013;8:12.
Conceptualization: Wei-Na Jin, Songling Wang, Fu-Dong doi: 10.1186/1745-6150-8-12
Shi
Formal analysis: Yingying Su, Hao Wang, Jian Zhou 6. Kiernan MC, Vucic S, Cheah BC, et al. Amyotrophic lateral
Methodology: Shihe Jiang, Xiuchen Guan, Meng Shi, Ying sclerosis. Lancet. 2011;377(9769):942-955.
Zhang, Xindi Li doi: 10.1016/s0140-6736(10)61156-7
Writing–original draft: Wei-Na Jin, Songling Wang, 7. Bruijn LI, Houseweart MK, Kato S, et al. Aggregation
Fu-Dong Shi, Shihe Jiang, Xiuchen Guan and motor neuron toxicity of an ALS-linked SOD1
Writing–review & editing: Wei-Na Jin, Songling Wang, mutant independent from wild-type SOD1. Science.
Fu-Dong Shi 1998;281(5384):1851-1854.

Ethics approval and consent to participate doi: 10.1126/science.281.5384.1851
8. Oskarsson B, Gendron TF, Staff NP. Amyotrophic
The hDPSCs were extracted from healthy volunteers’ lateral sclerosis: An update for 2018. Mayo Clin Proc.
third molars, which were obtained from the Dental 2018;93(11):1617-1628.
Clinic of the Beijing Stomatological Hospital, with ethical
approval (Approval Number: KJ-2021- 016-C-01-CS, doi: 10.1016/j.mayocp.2018.04.007
Beijing, China). The written informed consent was 9. Brooks BR, Berry JD, Ciepielewska M, et al. Intravenous
provided to all donors who participated in the study. All edaravone treatment in ALS and survival: An
experimental procedures were performed in accordance exploratory, retrospective, administrative claims analysis.
with the guidelines of the Institutional Animal Care, Use EClinicalMedicine. 2022;52:101590.
Committee of Beijing Tiantan Hospital, and the Chinese doi: 10.1016/j.eclinm.2022.101590
Small Animal Protection Association Experimental 10. Ford E, Pearlman J, Ruan T, et al. Human pluripotent
Protocol with approval from the IACUC under protocol stem cells-based therapies for neurodegenerative diseases:
number 202203004. Current status and challenges. Cells. 2020;9(11):2517.
Consent for publication doi: 10.3390/cells9112517

Not applicable. 11. De Gioia R, Biella F, Citterio G, et al. Neural stem cell
transplantation for neurodegenerative diseases. Int J Mol Sci.
Availability of data 2020;21(9):3103.
Not applicable. doi: 10.3390/ijms21093103
12. Wang D, Wang Y, Tian W, Pan J. Advances of tooth-derived
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