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Brain & Heart Cardioneuroablation for VMB

Table 1. General characteristics and quality assessments of the included studies
Study Year Design Region Number of Indications Locations of Follow-up Quality of study
patients targeted GPs (months) (NOS score)
Pachon et al. 6 2005 retrospective Brazil 20 SND, AVB RA/LA 9.2±4.1 6
Zhao et al. 12 2015 retrospective China 11 SB RA/LA 18.4±6.2 6
Aksu et al. 13 2016 prospective Turkey 14 SND, AVB RA/LA 10.9±3.3 7
Qin et al. 16 2017 prospective China 62 SB RA/LA 12 8
Debruyne et al. 19 2018 prospective Belgium 8 SND RA 12 6
Güler et al. 32 2020 retrospective Turkey 11 SND, AVB RA/LA 52 (28 – 56) 7
Lu et al. 33 2020 retrospective China 13 SND, AVB RA/LA 13.0±5.9 7
Aksu et al. 24 2021 prospective Turkey 31 AVB RA/LA - 8
Aksu et al. 34 2021 retrospective Turkey 19 SND, AVB RA/LA 14.9±17 7
Debruyne et al. 25 2021 prospective Belgium 19 SND RA 12 7
Mesquita et al. 35 2021 prospective Portugal 13 SND, AVB RA/LA 6.5±23.4 6
Aksu et al. 26 2022 prospective Turkey 13 SND, AVB RA/LA 8.0±3 7
Chen et al. 36 2022 retrospective China 6 SND RA/LA 6 6
Piotrowski et al. 27 2022 prospective Poland 25 SND, AVB RA/LA 10±3 7
Rivarola et al. 37 2023 prospective Brazil 36 SND, AVB RA/LA 52.1±35.2 8
Song et al. 38 2023 prospective China 73 SB RA/LA 27.2±17.4 8
Wileczek et al. 28 2023 retrospective Poland 178 SND, AVB RA/LA 23.7 7
Choi et al. 29 2024 retrospective USA 6 SND, AVB RA/LA 7.9 6
Han et al. 39 2024 prospective China 60 SND LA 12 8
Abbreviations: SND: Sinus node dysfunction; AVB: Atrioventricular block; SB: Sinus bradycardia; RA: Right atrium; LA: Left atrium;
GPs: Ganglionated plexi; NOS: Newcastle–Ottawa Scale.

Figure 4. Forest plot of freedom from bradyarrhythmia-related symptoms. At the end of follow-up, 94.3% of patients (95% confidence interval: 90.9 – 97.7%,
I² = 59%) were free from bradyarrhythmia-related symptoms.

required pacemaker implantation after the procedure. 3.2.3. Procedure-related complications
The sensitivity analysis indicated that no individual study The incidence of procedure-related complications was
significantly altered the overall results. analyzed in 294 patients from 7 studies using a common-

Volume 3 Issue 1 (2025) 5 doi: 10.36922/bh.4824