Page 92 - BH-3-1

Brain & Heart Brain lesions with PROKR2 microduplication

from systolic overload-induced congestive heart failure. 13. Cheng MY, Lee AG, Culbertson C, et al. Prokineticin 2 is an
Circulation. 2014;129:1397-1406. endangering mediator of cerebral ischemic injury. Proc Natl
Acad Sci U S A. 2012;109(14):5475-5480.
doi: 10.1161/CIRCULATIONAHA.113.002209
doi: 10.1073/pnas.1113363109
7. Balachandran S, Roberts PC, Kipperman T, et al. Alpha/
beta interferons potentiate virus-induced apoptosis through 14. Younes H, Kyritsi I, Mahrougui Z, Benharouga M,
activation of the FADD/Caspase-8 death signaling pathway. Alfaidy N, Marquette C. Effects of prokineticins on cerebral
J Virol. 2000;74(3):1513-1523. cell function and blood-brian barrier permeability. Int J Mol
Sci. 2023;24:15428.
doi: 10.1128/jvi.74.3.1513-1523.2000
doi: 10.3390/ijms242015428
8. Boriushkin E, Wang JJ, Li J, Bhatta M, Zhang S. P58
IPK
suppresses NLRP3 inflammasome activation and IL-1ß 15. Dhar A. The role of PKR as a potential target for treating
production via inhibition of PKR in macrophages. Sci cardiovascular disease. Curr Cardiol Rev. 2017;13:28-31.
Rep. 2016;6:25013.
doi: 10.2174/1573403x12666160526122600
doi: 10.1038/srep25013
16. Lalani SR, Thakuria JV, Cox GF, et al. 20p12.3 Microdeletion
9. Wang Y, Men M, Xie B, et al. Inihibition of PKR protects predisposes to Wolff-Parkinson-White syndrome with
against H O -induced injury on neonatal cardiac variable neurocognitive deficits. J Med Genet. 2009;46:
2
2
myocytes by attenuating apoptosis and inflammation. Sci 168-175.
Rep. 2016;6:38753.
doi: 10.1136/jmg.2008.061002
doi: 10.1038/srep38753
17. Mills KI, Anderson J, Levy PT, et al. Duplication of 20p12.3
10. Stewart MJ, Blum MA, Sherry B. PKR’s protective role in associated with familial Wolff-Parkinson-White syndrome.
viral myocarditis. Virology. 2003;314:92-100. Am J Med Genet Part A. 2012;161A:137-144.
doi: 10.1016 S0042-6822(03)j00414-8 doi: 10/1002/ajmg.a.35701
11. Lin SS, Lee DCW, Law AHY, Fang JW, Chua DTT, Lau ASY. 18. Xiao J, Tan Y, Li Y, Luo Y. The specific protein kinase R (PKR)
A role for protein kinase PKR in the mediation of Epstein- inhibitor C16 protects neonatal hypoxia-ischemia brain
Barr virus latent membrane protein-1-induced IL-6 and damages by inihibiting neuroinflammation in a neonatal rat
IL-10 expression. Cytokine. 2010;50(2):210-219. model. Med Sci Monit. 2016;22:5074-5081.
doi: 10.1016/j.cyto.2010.01.008 doi: 10.12659/MSM.898139
12. Bleiblo F, Michael P, Brabant D, et al. Bacterial RNA induced 19. Reynaud D, Sergent F, Abi Nahed R, et al. Evidence-based
myocyte cellular dysfunction through the activation of PKR. view of safety and effectiveness of prokineticin receptors
J Thorac Dis. 2012;4(2):114-125. antagonists during pregnancy. Biomedicines. 2021;9:309.
doi: 10.3978/j.issn.2072-1439.2012.01.07 doi: 10.3390/biomedicines9030309

Volume 3 Issue 1 (2025) 5 doi: 10.36922/bh.4281