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Brain & Heart Combination of EDN and RDN treatment

The number of oral antihypertensive drugs was continue follow-up with the patient, but the result needs to
adjusted from four types before surgery to three types after be further verified through additional clinical practice.
a month and to two types after 3 months. At 6 months
after surgery, the average 24-h ambulatory blood pressure 4. Conclusion
dropped to 55/20 mmHg. At a year after surgery, the The patient with uncontrolled drug-treated hypertension
average 24-h ambulatory blood pressure was normal, and type 2 diabetes was successfully treated with EDN
while the antidiabetic drugs used were the same as before combined with RDN under three-dimensional guidance
surgery; the glycated hemoglobin dropped by 4.6%; the through Ensite Velocity 5.0 system. The positive results
fasting blood glucose dropped by 6.8 mmol/L; and the 2-h provide new opportunities for the treatment of patients
blood glucose levels after three meals (breakfast, lunch, with similar disease profiles.
and dinner) dropped by 9.1 mmol/L, 13.6 mmol/L, and
4.3 mmol/L, respectively. No complications related to Acknowledgments
surgery were reported (Table 2).
None.
3. Discussion
Funding
This report presents the first patient in China successfully th
treated with END combined with RDN for uncontrolled This work was supported by the 940 Hospital of the
drug-treated hypertension with type 2 diabetes under three- Joint Logistics Support Force of the Chinese People’s
dimensional guidance. The keys to significant curative effect: Liberation Army (grant number 2021yxky080 to Ling
pre-operative and intraoperative procedures. Pre-operative Ma, grant number 2021yxky031 to Fei Wang), the Gansu
procedure includes improvement in relevant laboratory Province Health Industry Plan Project (grant number
examinations to clarify the diagnosis, along with renal GSWSKY2023–47 to Ling Ma), the Gansu Province Science
artery imaging and bilateral renal artery plus celiac trunk and Technology Plan Project (grant number 22JR5RA013
angiography to accurately obtain anatomical features. For to Fangju Su), the Lanzhou Youth Science and Technology
intraoperative improvement, the Ensite Velocity 5.0 system Talent Innovation Project (grant number 2024-QN-41 to
was innovatively used for three-dimensional modeling. Juan Feng), and the Northwest University for Nationalities
The three-dimensional guidance has been widely used Central University Major Demand Cultivation Project
in electrophysiological examination and ablation. 12,13 The (grant number 31920220109 to Fangju Su).
emergence and application of three-dimensional guidance Conflict of interest
systems are not only facilitate the identification of precise
target sites and improve the success rate of catheter ablation The authors declare they have no competing interests.
treatments but also reduce the need for X-ray fluoroscopy.
This results in enhanced protection for both medical Author contributions
staff and patients, while minimizing complications such Conceptualization: Piqi Jiao
as radiation dermatitis and leukopenia. 14,15 A stable and Investigation: Peng Zhang, Fei Wang, Piqi Jiao
reliable three-dimensional model of the renal artery can Writing–original draft: Fangju Su, Juan Feng
be generated, enabling the visualization of the entire renal Writing–review & editing: Ling Ma
artery. This not only facilitates more accurate identification
of the target for spiral ablation but also avoids repeated X-ray Ethics approval and consent to participate
exposure to confirm the ablation site, thereby significantly The ethics committee approved the study of the
reducing the radiation exposures. In addition, the application 940 Hospital of the Joint Logistics Support Force of the
th
of pressure ablation catheters ensures the effectiveness of Chinese People’s Liberation Army. Written informed
ablation. Furthermore, impedance and pressure parameters consent was obtained from the individual(s) for the
can be used to ensure the safety of ablation and reduce the publication of data included in this article.
occurrence of vascular dissection, rupture, and stenosis.
Compared with the previous ablation method using Consent for publication
non-pressure ablation catheter under X-ray guidance,
our procedure not only improves the ablation effect and Written informed consent was obtained from the individual(s)
reduces complications but also avoids long-term radiation for the publication of data included in this article.
exposures. Our preliminary experience proves the safety and Availability of data
effectiveness of the two surgeries performed simultaneously,
which is worthy of wider applications. It would be valuable to Not applicable.

Volume 3 Issue 3 (2025) 5 doi: 10.36922/bh.5123