Page 89 - BH-3-3

Brain & Heart

CASE REPORT
Endovascular denervation combined with

renal sympathetic denervation for treating
uncontrolled drug-treated hypertension with

type 2 diabetes: A case report

Fangju Su , Juan Feng † , Ling Ma*, Peng Zhang, Fei Wang, and Piqi Jiao
†
Department of Cardiovascular Medicine, Hospital of Joint Logistics Support Force of Chinese
People’s Liberation Army, China

Abstract

Uncontrolled drug-treated hypertension can lead to serious cardiovascular and
cerebrovascular events. Type 2 diabetes mellitus has caused a huge health burden
† These authors contributed equally worldwide, with the global prevalence of chronic hyperglycemia or diabetes
to this work.
being approximately 1 in 11 among adults. Even in patients who are compliant
*Corresponding author: with medication treatment and lifestyle changes, glycemic control may still be
Ling Ma
(lqbzbd940ml@126.com) inadequate. In this case report, a young Chinese patient with uncontrolled drug-
treated hypertension and type 2 diabetes was successfully treated with endovascular
Citation: Su F, Feng J, Ma L,
Zhang P, Wang F, Jiao P. denervation combined with renal sympathetic denervation under three-dimensional
Endovascular denervation guidance through the Ensite Velocity 5.0 system. The positive results from this
combined with renal sympathetic study provide new opportunities for the treatment of uncontrolled drug-treated
denervation for treating uncontrolled
drug-treated hypertension with hypertension with type 2 diabetes.
type 2 diabetes: A case report. Brain
& Heart. 2025;3(3):5123.
doi: 10.36922/bh.5123 Keywords: Uncontrolled drug-treated hypertension; Type 2 diabetes; Endovascular
denervation; Renal sympathetic denervation; Three-dimensional modeling; Pressure
Received: October 12, 2024
ablation catheter
1st revised: December 1, 2024
2nd revised: December 12, 2024
3rd revised: December 20, 2024 1. Introduction
Accepted: January 6, 2025
Hypertension is a leading cause of death and disability worldwide. Lowering blood
1
Published online: February 3, pressure has been shown to reduce the risk of cardiovascular events and mortality.
2-5
2025
Uncontrolled drug-treated hypertension can lead to severe cardiovascular and
Copyright: © 2025 Author(s). cerebrovascular events. Studies have shown that the kidneys play a two-way regulatory
This is an Open Access article role in the regulation of blood pressure. Excessive activation of sympathetic nerves is
6,7
distributed under the terms of the
Creative Commons Attribution an important mechanism in the development of hypertension and the occurrence of
License, permitting distribution, cardiovascular events.
and reproduction in any medium,
provided the original work is Multiple studies have confirmed the effectiveness and safety of renal sympathetic
properly cited. denervation (RDN) in the treatment of uncontrolled drug-treated hypertension.
8,9
Publisher’s Note: AccScience Despite best efforts with lifestyle and pharmacological intervention, RDN presents an
Publishing remains neutral with attractive adjunctive therapy for patients with resistant or uncontrolled drug-treated
regard to jurisdictional claims in 10
published maps and institutional hypertension. RDN may also be used in patients who cannot tolerate long-term use of
affiliations. antihypertensive medications.

Volume 3 Issue 3 (2025) 1 doi: 10.36922/bh.5123