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Brain & Heart                                                 Anteroinferior native septum TSP with ASD Device



                                                               patients with atrial septal ASD closure device was 77.7%,
                                                               and comparing native TSP versus TSP on the ASD closure
                                                        Abbreviations: AF: Atrial fibrillation; CTI: Cavotricuspid isthmus; LA: Left atrium; LVEF: Left ventricular ejection fraction; PAF: Paroxysmal atrial fibrillation; PeAF: Persistent atrial fibrillation;
                 Case 8  67  Female  40  PeAF  46  65  Single puncture  Antero-inferior  12  PVI + roof line  45  3  No  device, no significant difference in recurrence of AF. 11
                                                               3.1. Intracardiac echocardiography and selection of
                                                               puncture site
                                   Single puncture  Antero-inferior  5  PVI + posterior   box line  42  3  Yes  To  mitigate  the  risk  of  complications,  the TSP  should
                      Female
                                                               be performed under transesophageal echocardiography
                 Case 7                                        or ICE guidance. In our series of cases, we used ICE to
                           PeAF
                              41
                         12
                                 77
                    70
                                                               select the puncture site and advanced the needle and the
                                                               sheath from the right atrium to the LA. Ensuring accurate
                                                               visualization of the native septum and its relationship with
                 Case 6  46  Female  26  PAF  36  58  Single puncture  Antero-inferior  6  PVI + anterior   line + CTI  36  3  No  adjacent structures is crucial to avoid complications. An
                                                               anteriorly directed ICE view will demonstrate the anterior
                                                               LA structures, including the mitral valve and LAA, with
                                                               the aortic root. A more posterior view will show the left
                                                               pulmonary veins, but in this view, there is usually not
                 Case 5  52  Female  34  PAF  47  64  Single puncture  Antero-inferior  7  PVI + posterior   box line  38  22  No  enough native septum if the device is large.
                                                                 When the sheath and the dilator are positioned in the
                                                               native septum, careful attention should be paid to ensuring
                                                               that the transseptal needle is not directed toward the aortic
                                   Single puncture  Antero-inferior  4  PVI  31  11  No  and inferiorly, away from the aortic root, to avoid inadvertent
                                                               root. The puncture site should be situated more posteriorly
                 Case 4                                        puncture. In the inferior area, care should be taken not to
                           PeAF
                      Male
                              38
                         14
                                 62
                    56
                                                               puncture too low, avoiding puncture of the coronary sinus.
                                                                 There was a report describing successful TSP procedures
                                                               performed even in the presence of a large closure device
                 Case 3  46  Female  26  PAF  36  66  Single puncture  Antero-inferior  6  PVI + roof line  20   3  Yes  (30 mm), but the puncture site was in the posteroinferior
                                                                                  12
                                                               site of the native septum.  The anteroinferior site of the TSP
                                                               approach can also be applied for not only radiofrequency
                                                               (RF) ablation but also pulse field ablation.  In this case
                                                                                                  13
                                                               series, based on 3D reconstruction cardiac CT scan, we
                                   Single puncture  Antero-inferior  6  PVI  19  7  Yes  found that the anteroinferior site of the native septum
                 Case 2  Female                                featured more area not covered by the closure device
                           PAF
                    64
                                 66
                              34
                         28
                                                               compared to the posteroinferior site, even when a very
                                                               large device was used (40 mm). Our findings underscore
                                                               imaging guidance in navigating AF ablation, with the aim
                 Case 1   54   Male  10  PAF  35  68  Single puncture  Antero-inferior  4  PVI  32   6  Yes  the importance of procedural planning and meticulous
                                                               of ensuring procedural safety and efficacy.
             Table 1. Baseline clinical characteristics  Size of closure device (mm)  Location of TSP  TSP duration (minutes)  AF ablation strategy  RF ablation duration (minutes) Follow-up after AF ablation (months)  AF recurrence after ablation  RF: Radiofrequency; TSP: Transseptal puncture.  sample and entailed a relatively short duration in follow-up
                                                                 Several limitations of this report should be
                                                               acknowledged. This case series includes a relatively small
                                                               of patients. This case series with relatively small samples,
                                                               and a relatively short duration of follow-up. In this case
                                                               series, we did not compare between puncturing the native
                                                               septum  in  the  anteroinferior  or  posteroinferior  site  and
                                                               direct puncture to the device in patient AF ablation.
                                                               4. Conclusion
                           Type of AF
                    Age (years)
                      Gender
                                                               cardiac CT scan provides valuable information about


            Volume 3 Issue 3 (2025)  LA size (mm)  LVEF (%)  TSP  4  Pre-procedural  imaging  such  as  3D  reconstruction
                                                                                             doi: 10.36922/bh.5119
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