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Eurasian Journal of Medicine and
Oncology
T2D polymorphisms in Asians

experimental framework. Ann Ig. 2024;36(2):153-168. population. Biosci Rep. 2020;40(5):BSR20193955.
doi: 10.7416/ai.2024.2600 doi: 10.1042/BSR20193955
8. Nitert MD, Dayeh T, Volkov P, et al. Impact of an exercise 18. Regué L, Zhao L, Ji F, Wang H, Avruch J, Dai N. RNA
intervention on DNA methylation in skeletal muscle m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell
from first-degree relatives of patients with type 2 diabetes. proliferation and insulin secretion by enhancing PDX1
Diabetes. 2012;61(12):3322-3332. expression. Mol Metab. 2021;48:101209.
doi: 10.2337/db11-1653 doi: 10.1016/j.molmet.2021.101209
9. Hu C, Zhang R, Wang C, et al. PPARG, KCNJ11, CDKAL1, 19. Peiris H, Park S, Louis S, et al. Discovering human diabetes-
CDKN2A-CDKN2B, IDE-KIF11- HHEX, IGF2BP2 and risk gene function with genetics and physiological assays.
SLC30A8 are associated with type 2 diabetes in a Chinese Nat Commun. 2018;9(1):3855.
population. PLoS One. 2009;4(10):e7643.
doi: 10.1038/s41467-018-06249-3
doi: 10.1371/journal.pone.0007643
20. Jonsson A, Ladenvall C, Ahluwalia TS, et al. Effects of
10. Suzuki K, Akiyama M, Ishigaki K, et al. Identification of 28 common genetic variants associated with type 2 diabetes
new susceptibility loci for type 2 diabetes in the Japanese and glycemic traits on α- and β-cell function and insulin
population. Nat Genet. 2019;51(3):379-386. action in humans. Diabetes. 2013;62(8):2978-2983.
doi: 10.1038/s41588-018-0332-4 doi: 10.2337/db12-1627
11. Dimas AS, Lagou V, Barker A, et al. Impact of type 2 diabetes 21. Simonis-Bik AM, Nijpels G, van Haeften TW, et al. Gene
susceptibility variants on quantitative glycemic traits reveals variants in the novel type 2 diabetes loci CDC123/CAMK1D,
mechanistic heterogeneity. Diabetes. 2014;63(6):2158-2171. THADA, ADAMTS9, BCL11A, and MTNR1B affect
different aspects of pancreatic β-cell function. Diabetes.
doi: 10.2337/db13-0949
2010;59(1):293-301.
12. Kulzer JR, Stitzel ML, Morken MA, et al. A common
functional regulatory variant at a type 2 diabetes locus doi: 10.2337/db09-1048
upregulates ARAP1 expression in the pancreatic beta cell. 22. Nicolson TJ, Bellomo EA, Wijesekara N, et al. Insulin
Am J Hum Genet. 2014;94(2):186-197. storage and glucose homeostasis in mice null for the granule
zinc transporter ZnT8 and studies of the type 2 diabetes-
doi: 10.1016/j.ajhg.2013.12.011
associated variants. Diabetes. 2009;58(9):2070-2083.
13. Ramzy A, Asadi A, Kieffer TJ. Revisiting proinsulin
processing: Evidence that human β-cells process proinsulin doi: 10.2337/db09-0551
with prohormone convertase (PC) 1/3 but not PC2. Diabetes. 23. Mitchell RK, Hu M, Chabosseau PL, et al. Molecular genetic
2020;69(7):1451-1462. regulation of Slc30a8/ZnT8 reveals a positive association
with glucose tolerance. Mol Endocrinol. 2016;30(1):77-91.
doi: 10.2337/db19-0276
doi: 10.1210/me.2015-1227
14. Jonsson A, Isomaa B, Tuomi T, Eriksson JG, Groop L,
Lyssenko V. Effect of a common variant of the PCSK2 gene 24. Kirchhoff K, Machicao F, Haupt A, et al. Polymorphisms in
on reduced insulin secretion. Diabetologia. 2012;55(12): the TCF7L2, CDKAL1 and SLC30A8 genes are associated
3245-3251. with impaired proinsulin conversion. Diabetologia.
2008;51(4):597-601.
doi: 10.1007/s00125-012-2728-5
doi: 10.1007/s00125-008-0926-y
15. Mellado-Gil JM, Fuente-Martín E, Lorenzo PI, et al. The
type 2 diabetes-associated HMG20A gene is mandatory 25. Staiger H, Machicao F, Stefan N, et al. Polymorphisms
for islet beta cell functional maturity. Cell Death Dis. within novel risk loci for type 2 diabetes determine β-cell
2018;9(3):279. function. PLoS One. 2007;2(9):e832.
doi: 10.1038/s41419-018-0272-z doi: 10.1371/journal.pone.0000832
16. Jian X, Felsenfeld G. Insulin promoter in human pancreatic 26. Zeng H, Guo M, Zhou T, et al. An isogenic human ESC
β cells contacts diabetes susceptibility loci and regulates platform for functional evaluation of genome-wide-
genes affecting insulin metabolism. Proc Natl Acad Sci U S association-study-identified diabetes genes and drug
A. 2018;115(20):E4633-E4641. discovery. Cell Stem Cell. 2016;19(3):326-340.
doi: 10.1073/pnas.1803146115 doi: 10.1016/j.stem.2016.07.002
17. Huang T, Wang L, Bai M, et al. Influence of IGF2BP2, 27. Bankura B, Pattanayak AK, Ghosh S, Guria S, Sinha A, Das
HMG20A, and HNF1B genetic polymorphisms on the M. Implication of KCNJ11 and TCF7L2 gene variants for the
susceptibility to Type 2 diabetes mellitus in Chinese Han predisposition of type 2 diabetes mellitus in West Bengal,

Volume 9 Issue 1 (2025) 87 doi: 10.36922/ejmo.7549