Page 291 - EJMO-9-2
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Eurasian Journal of
            Medicine and Oncology                                          QGJSF multi-target mechanisms in osteoporosis



               doi: 10.1096/fj.10-162230                          doi: 10.1016/j.bone.2011.05.023
            45.  Yao Z, Getting SJ, Locke IC. Regulation of TNF-induced   56.  Y Ye C, Zhang W, Hang K,  et al. Extracellular IL-37
               osteoclast differentiation. Cells. 2021;11(1):132.  promotes osteogenic differentiation of human bone marrow
                                                                  mesenchymal stem cells via activation of the PI3K/AKT
               doi: 10.3390/cells11010132
                                                                  signaling pathway. Cell Death Dis. 2019;10(10):753.
            46.  Miyauchi Y, Sato Y, Kobayashi T, et al. HIF1α is required
               for osteoclast activation by estrogen deficiency in      doi: 10.1038/s41419-019-1904-7
               postmenopausal osteoporosis.  Proc Natl Acad Sci U S  A.   57.  Zhou H, Jiao G, Dong M, et al. Orthosilicic acid accelerates
               2013;110(41):16568-16573.                          bone formation in human osteoblast-like cells through
                                                                  the PI3K-Akt-mTOR pathway.  Biol Trace Elem Res.
               doi: 10.1073/pnas.1308755110
                                                                  2019;190(2):327-335.
            47.  Wan C, Shao J, Gilbert SR, et al. Role of HIF-1α in skeletal      doi: 10.1007/s12011-018-1574-9
               development. Ann N Y Acad Sci. 2010;1192:322-326.
                                                               58.  Bartell SM, Kim HN, Ambrogini E,  et al. FoxO proteins
               doi: 10.1111/j.1749-6632.2009.05238.x
                                                                  restrain osteoclastogenesis and bone resorption by
            48.  Medema  RH,  Kops  GJ,  Bos  JL,  Burgering  BM.  AFX-  attenuating H2O2 accumulation. Nat Commun. 2014;5:3773.
               like  forkhead  transcription  factors  mediate  cell-cycle      doi: 10.1038/ncomms4773
               regulation by ras and PKB through p27kip1.  Nature.
               2000;404(6779):782-787.                         59.  Feng Y. Ph.D. Thesis. China: Lanzhou University; 2018.
               doi: 10.1038/35008115                           60.  Sugatani  T,  Alvarez  U,  Hruska  KA.  PTEN  regulates
                                                                  RANKL-  and osteopontin-stimulated signal transduction
            49.  Tran H, Brunet A, Grenier JM,  et  al. DNA repair   during osteoclast differentiation and cell motility.  J  Biol
               pathway stimulated by the forkhead transcription   Chem. 2003;278(7):5001-5008.
               factor  FOXO3a  through  the  gadd45  protein.  Science.
               2002;296(5567):530-534.                            doi: 10.1074/jbc.M209299200
               doi: 10.1126/science.1068712                    61.  Stein GH, Drullinger LF, Soulard A, Dulić V. Differential
                                                                  roles for cyclin-dependent kinase inhibitors p21 and p16 in
            50.  Kops GJ, Dansen TB, Polderman PE,  et al. Forkhead   the mechanisms of senescence and differentiation in human
               transcription factor FOXO3a protects quiescent cells from   fibroblasts. Mol Cell Biol. 1999;19(3):2109-2117.
               oxidative stress. Nature. 2002;419(6904):316-321.
                                                                  doi: 10.1128/MCB.19.3.2109
               doi: 10.1038/nature01036
                                                               62.  Xia C, Jiang T, Wang Y, Chen X, Hu Y, Gao Y. The p53/
            51.  Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell   miR-145a axis promotes cellular senescence and inhibits
               survival by phosphorylating and inhibiting a forkhead   osteogenic differentiation by targeting cbfb in mesenchymal
               transcription factor. Cell. 1999;96(6):857-868.    stem cells. Front Endocrinol (Lausanne). 2021;11:609186.
               doi: 10.1016/s0092-8674(00)80595-4                 doi: 10.3389/fendo.2020.609186
            52.  Nemoto S, Finkel T. Redox regulation of forkhead proteins   63.  Kim HJ, Kim WJ, Shin HR,  et al. ROS-induced PADI2
               through a p66shc-dependent signaling pathway.  Science.   downregulation accelerates cellular senescence via the
               2002;295(5564):2450-2452.                          stimulation of SASP production and NFκB activation. Cell
               doi: 10.1126/science.1069004                       Mol Life Sci. 2022;79(3):155.
            53.  Speckmann B, Walter PL, Alili L,  et al. Selenoprotein      doi: 10.1007/s00018-022-04186-5
               P expression is controlled through interaction of the   64.  Lian WS, Wu RW, Chen YS, et al. MicroRNA-29a mitigates
               coactivator PGC-1alpha with FoxO1a and hepatocyte   osteoblast senescence and counteracts bone loss through
               nuclear factor 4alpha transcription factors.  Hepatology.   oxidation resistance-1 Control of FoxO3 methylation.
               2008;48(6):1998-2006.                              Antioxidants (Basel). 2021;10(8):1248.
               doi: 10.1002/hep.22526.                            doi: 10.3390/antiox10081248
            54.  Sidhu  A,  Miller  PJ,  Hollenbach  AD.  FOXO1  stimulates   65.  Raynaud-Messina B, Verollet C, Maridonneau-Parini I.
               ceruloplasmin  promoter  activity  in  human  hepatoma   The  osteoclast,  a  target  cell  for  microorganisms.  Bone.
               cells treated with IL-6.  Biochem  Biophys Res Commun.   2019;127:315-323.
               2011;404(4):963-967.
                                                                  doi: 10.1016/j.bone.2019.06.023
               doi: 10.1016/j.bbrc.2010.12.089
                                                               66.  Tokunaga T, Mokuda S, Kohno H, et al. TGFβ1 regulates
            55.  Almeida M. Unraveling the role of FoxOs in bone-insights   human RANKL-induced osteoclastogenesis via suppression
               from mouse models. Bone. 2011;49(3):319-327.       of NFATc1 expression. Int J Mol Sci. 2020;21(3):800.


            Volume 9 Issue 2 (2025)                        283                         doi: 10.36922/EJMO025150103
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