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Eurasian Journal of
            Medicine and Oncology                                          QGJSF multi-target mechanisms in osteoporosis



               therapeutics  post-menopausal  osteoporosis.  Cureus.   14.  Quan GH, Wang H, Cao J,  et  al. Calycosin suppresses
               2023;15(8):e42870.                                 RANKL-mediated osteoclastogenesis through inhibition of
               doi: 10.7759/cureus.42870                          MAPKs and NF-κB. Int J Mol Sci. 2015;16(12):29496-29507.
            4.   Wang L, Huang X, Qin J, et al. The role of traditional Chinese      doi: 10.3390/ijms161226179
               medicines in the treatment of osteoporosis. Am J Chin Med.   15.  Li N, Tu Y, Shen Y, Qin Y, Lei C, Liu X. Calycosin attenuates
               2024;52(4):949-986.                                osteoporosis and regulates the expression of OPG/RANKL
               doi: 10.1142/S0192415X24500393                     in ovariectomized rats  via MAPK signaling.  Pharmazie.
                                                                  2016;71(10):607-612.
            5.   Xiong M, Chen X, Wang H,  et  al. Combining
               transcriptomics and network pharmacology to reveal      doi: 10.1691/ph.2016.6627
               the mechanism of zuojin capsule improving spasmolytic   16.  Duan X, Meng Q, Wang C,  et al. Calycosin attenuates
               polypeptide-expressing  metaplasia.  J  Ethnopharmacol.   triglyceride accumulation and hepatic fibrosis in murine
               2024;318(Pt B):117075.                             model of non-alcoholic steatohepatitis via activating
               doi: 10.1016/j.jep.2023.117075                     farnesoid X receptor. Phytomedicine. 2017;25:83-92.
            6.   Yu W, Li X, Sun Q,  et al. Metabolomics and network      doi: 10.1016/j.phymed.2016.12.006
               pharmacology reveal the mechanism of Castanopsis honey   17.  Li Z, Geng YN, Jiang JD, Kong WJ. Antioxidant and anti-
               against Streptococcus pyogenes. Food Chem. 2024;441:138388.  inflammatory activities of berberine in the treatment of
               doi: 10.1016/j.foodchem.2024.138388                diabetes  mellitus.  Evid Based Complement Alternat Med.
                                                                  2014;2014:289264.
            7.   Zhu H, Wang S, Shan C, et al. Mechanism of protective effect
               of xuan-bai-cheng-qi decoction on LPS-induced acute lung      doi: 10.1155/2014/289264
               injury based on an integrated network pharmacology and   18.  Lee JW, Mase N, Yonezawa T,  et al. Palmatine attenuates
               RNA-sequencing approach. Respir Res. 2021;22(1):188.
                                                                  osteoclast differentiation and function through inhibition of
               doi: 10.1186/s12931-021-01781-1                    receptor activator of nuclear factor-κb ligand expression in
                                                                  osteoblast cells. Biol Pharm Bull. 2010;33(10):1733-1739.
            8.   Deng TT, Ding WY, Lu XX,  et al. Pharmacological and
               mechanistic aspects of quercetin in osteoporosis.  Front      doi: 10.1248/bpb.33.1733
               Pharmacol. 2024;15:1338951.
                                                               19.  Chen ZZ. Berberine induced apoptosis of human
               doi: 10.3389/fphar.2024.1338951                    osteosarcoma cells by inhibiting phosphoinositide 3 kinase/
                                                                  protein kinase B (PI3K/Akt) signal pathway activation. Iran
            9.   Xiong Y, Huang CW, Shi C, et al. Corrigendum: Quercetin
               suppresses  ovariectomy-induced  osteoporosis  in rat   J Public Health. 2016;45(5):578-585.
               mandibles by regulating autophagy and the NLRP3 pathway.   20.  Li H, Miyahara T, Tezuka Y, Tran QL, Seto H, Kadota S.
               Exp Biol Med (Maywood). 2024;249:10149.            Effect of berberine on bone mineral density in SAMP6
               doi: 10.3389/ebm.2024.10149                        as a senile osteoporosis model.  Biol Pharm Bull.
                                                                  2003;26(1):110-111.
            10.  Wu S, Zhao F, Zhao J, et al. Dioscin improves postmenopausal
               osteoporosis through inducing bone formation and      doi: 10.1248/bpb.26.110
               inhibiting apoptosis in ovariectomized rats. Biosci Trends.   21.  Matsushita K, Itoh S, Ikeda S, Yamamoto Y, Yamauchi  Y,
               2019;13(5):394-401.                                Hayashi M. LIF/STAT3/SOCS3 signaling pathway in
               doi: 10.5582/bst.2019.01186                        murine bone  marrow stromal  cells suppresses  osteoblast
                                                                  differentiation. J Cell Biochem. 2014;115(7):1262-1268.
            11.  Tao X, Qi Y, Xu L, et al. Dioscin reduces ovariectomy-induced
               bone loss by enhancing osteoblastogenesis and inhibiting      doi: 10.1002/jcb.24777
               osteoclastogenesis Pharmacol Res. 2020;151:104397.  22.  Vimalraj S, Arumugam B, Miranda PJ, Selvamurugan  N.
               doi: 10.1016/j.phrs.2019.104397                    Runx2: Structure, function, and phosphorylation in osteoblast
                                                                  differentiation. Int J Biol Macromol. 2015;78:202-208.
            12.  Li M, Yu Y, Xue K, et al. Genistein mitigates senescence of
               bone marrow mesenchymal stem cells via ERRα-mediated      doi: 10.1016/j.ijbiomac.2015.04.008
               mitochondrial biogenesis and mitophagy in ovariectomized   23.  Wang L, Yang H, Huang J, et al. Targeted ptpn11 deletion
               rats. Redox Biol. 2023;61:102649.                  in mice reveals the essential role of SHP2 in osteoblast
               doi: 10.1016/j.redox.2023.102649                   differentiation and skeletal homeostasis.  Bone Res.
                                                                  2021;9(1):6.
            13.  Wu Z, Liu L. The protective activity of genistein against bone
               and cartilage diseases. Front Pharmacol. 2022;13:1016981.     doi: 10.1038/s41413-020-00129-7
               doi: 10.3389/fphar.2022.1016981                 24.  Zhou S, Dai Q, Huang X,  et al. STAT3 is critical for


            Volume 9 Issue 2 (2025)                        281                         doi: 10.36922/EJMO025150103
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