Page 189 - EJMO-9-3

Eurasian Journal of
Medicine and Oncology Research on DSY in treating gastritis

STAT3 signaling pathway and the nuclear translocation compounds. Quantifying the therapeutic efficacy by using
of NF-κB, thereby mitigating structural and functional selected active compounds as quality control markers can
damage to the gastric mucosa. Yang et al. demonstrated substantially improve the accuracy and reliability of DSY’s
38
that caffeic acid attenuates hydrochloric acid/ethanol- quality evaluation. This study provides references and a
induced gastric inflammatory responses by inhibiting the basis for the development of such evaluation methods
JNK, IRAK1, and IRAK4 signaling pathways in a murine for DSY in the future. In addition, as a multi-component
model. In addition, numerous studies have shown that compound preparation, the mechanisms through which
Cry, salvianolic acid B, danshensu, neocryptotanshinone, DSY treats gastritis and prevents its progression to gastric
vanillin, vanillic acid, and bornyl acetate have significant cancer warrant further investigation.
anti-inflammatory activities. 39-46 These findings suggest that
DSY has a substantial material basis for the prevention and Acknowledgments
treatment of gastritis and its progression to gastric cancer. None.
Moreover, the constructed disease-core target-compound-
pathway interaction network suggests that DSY exerts its Funding
therapeutic effects through multiple targets and signaling This study was supported by the Science and
pathways, which may underlie its notable clinical efficacy. Technology Program of Tianjin, China (Grant numbers:
Half of the top 20 pathways analyzed by KEGG enrichment 24ZYJDSS00310 and 24ZYJDSS00300).
were associated with inflammation. Among them, MAPK
signaling pathway, NF-κB signaling pathway, p53 signaling Conflict of interest
pathway, and JAK-STAT signaling pathway are common
signaling pathways targeted in CAG treatment. 47,48 In Miaomiao Jiang is an Editorial Board Member of this journal,
but was not in any way involved in the editorial and peer-
addition, previous studies have shown that pathways review process conducted for this paper, directly or indirectly.
associated with inflammatory bowel disease, rheumatoid Separately, other authors declared that they have no known
arthritis, leukocyte transendothelial migration, and cell cycle competing financial interests or personal relationships that
are strongly associated with gastritis caused by H. pylori. 49-52 could have influenced the work reported in this paper.
These findings further demonstrate that DSY can effectively
alleviate and protect against inflammatory injury of the Author contributions
gastric mucosa, thereby preventing or treating gastritis.
Conceptualization: Miaomiao Jiang
4. Conclusion Formal analysis: Miaomiao Jiang, Jianbing Dong,
Zhirong Zhou
Clinical studies have shown that DSY demonstrates Investigation: Jianbing Dong, Zhirong Zhou
notable efficacy in the treatment of gastritis. As a multi- Methodology: Jianbing Dong, Zhirong Zhou, Peng Lei
component compound preparation, DSY contains diverse Writing–original draft: Jianbing Dong, Zhirong Zhou,
chemical constituents, and reliance on a single detection Yi Chen
method is insufficient to comprehensively elucidate Writing–review & editing: Jianbing Dong, Zhirong Zhou,
its material basis. Therefore, this study characterized Yi Chen, Qingrui Zhang
the nonvolatile compounds, volatile compounds, and
polysaccharides in DSY decoction using UHPLC-Orbitrap Ethics approval and consent to participate
Exploris MS, HS-GC-MS, and HPLC. Fifteen volatile
and fifty-two nonvolatile compounds were identified in Not applicable.
the DSY decoction, primarily originating from TX and Consent for publication
DS. In addition, polysaccharides in the DSY decoction,
primarily derived from SR and DS, consisted mainly of Not applicable.
galactose, glucose, and galacturonic acid. Finally, based
on a comprehensive characterization of DSY decoction, Availability of data
network pharmacology analysis identified 22 active Data is available from the corresponding author upon
compounds interacting with 55 core targets and modulating reasonable request.
10 inflammation-related signaling pathways, thereby
elucidating the potential mechanisms underlying the References
therapeutic effects of DSY in treating gastritis. However, this 1. Wafaey AA, El-Hawary SS, Abdelhameed MF, et al. Green
study lacks a systematic quality assessment of DSY and does synthesis of zinc oxide nanoparticles using ethanolic
not include an analysis of its blood-absorbed (bioavailable) extract of Gliricidia sepium (Jacq.) kunth. Ex. Walp.,

Volume 9 Issue 3 (2025) 181 doi: 10.36922/EJMO025160124