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Eurasian Journal of
            Medicine and Oncology                                                 ICU pharmacists and clinical outcomes

























            Figure 2. Forest plot comparing intensive care unit mortality rates between patients managed with and without critical care pharmacist involvement




















            Figure 3. Forest plot illustrating the effect of critical care pharmacist involvement on the rate of adverse drug events among intensive care unit patients,
            compared to standard care without pharmacist participation

                                                               reported more pronounced improvements in mortality
                                                               and ADEs.

                                                               3.7. Summary of study characteristics
                                                               Detailed characteristics of the included studies are
                                                               presented in  Table  2. Most studies were conducted in
                                                               tertiary academic centers, and the interventions typically
                                                               involved CCPs making direct pharmacotherapeutic
                                                               recommendations during interdisciplinary rounds.
                                                               Several studies also documented CCP contributions to
                                                               institutional policy development, formulary management,
                                                               and healthcare staff education, all of which may have
                                                               contributed to improved outcomes.
                                                               4. Discussion

                                                               This meta-analysis, involving 16 studies and 37,925
                                                               ICU patients, presents strong evidence that integrating
            Figure 4. Funnel plot evaluating potential publication bias in mortality
            outcomes                                           CCPs into ICUs is significantly associated with reduced
            Abbreviations: OR: Odds ratio; SE: Standard error  mortality and a lower incidence of ADEs. The findings


            Volume 9 Issue 3 (2025)                        231                         doi: 10.36922/EJMO025150116
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