Page 285 - EJMO-9-3

Eurasian Journal of Medicine

and Oncology

ORIGINAL RESEARCH ARTICLE
Efficacy of preperitoneal local anesthetic

infiltration on post-operative analgesia following
laparoscopic cholecystectomy

Noha Mohamed Abdelwahab Elsaid * , Ain El-Marwa Abdelmonem Abdallah
1
Hassan 1 , Ahmed Mohamed Said 2 , Mostafa R. Bakry 3 , Doaa Mohamed
Almonayery Ibrahim 1 , Marwa Ibrahim Eid 1 , Hayam Shaaban Soliman
Morsy 4 , Mostafa Mohamed Elsayed 1 , Nashwa Mohammed Ibrahiem 1 ,
Gihan Eissa Zahran 1 , Nahla Mohammed Eldeeb 1 , Mayada Yahia Elbohouty 1
, Heba Atwa Ahmed Atwa 2 , Gehan Abd Elrhman Eldesoky 1 , Eman A.
Salem 1 , Samia Sayed Ahmed 1 , Warda Demerdash Khalifa Ali 4 , and Tarek
Abdelmonem Abdelzaher 5
1 Department of Anesthesia, ICU and Pain Management, Faculty of Medicine, Al-Azhar University,
Cairo, Egypt
2 Department of General Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
3 Department of Reproductive Medicine and IVF, Dar-Al Nokhba Infertility and IVF Center, Cairo, Egypt
4 Department of Anesthesia, ICU and Pain Management, Faculty of Medicine, Al-Azhar University,
Assiut, Egypt
5 Department of Anesthesia, ICU and Pain Management, Faculty of Medicine, Minia University,
Minia, Egypt
*Corresponding author:
Noha Mohamed Abdelwahab Elsaid
(nohamohamed.medg@azhar.edu.
eg)
Abstract
Citation: Elsaid NMA, Hassan
AAA, Said AM, et al. Efficacy of
preperitoneal local anesthetic Introduction: Post-operative pain significantly impairs recovery, delaying hospital
infiltration on post-operative discharge after laparoscopic cholecystectomy. Effective pain management facilitates
analgesia following laparoscopic early ambulation, which diminishes the probability of post-operative complications.
cholecystectomy. Eurasian J Med
Oncol. 2025;9(3):277-286. Objective: This study compares the analgesic efficacy of preperitoneal bupivacaine
doi: 10.36922/EJMO025180164 infiltration with dexamethasone and the transversus abdominis plane (TAP) block.
Methods: This prospective, randomized, double-blinded study included 40 patients
Received: May 2, 2025
undergoing laparoscopic cholecystectomy. Group 1 (n = 20) received a TAP block,
Revised: June 7, 2025 while Group 2 (n = 20) received preperitoneal bupivacaine for analgesia. The primary
Accepted: August 1, 2025 outcomes were (i) the level of post-operative pain, assessed using the Visual Analog
Scale every 15 min in the 1 post-operative hour, at 2-h intervals up to 12 h, and at
st
Published online: September 23,
2025 6-h intervals up to 24 h; (ii) time to first request for rescue analgesia; and (iii) the total
dose of analgesia. Secondary outcomes included patient-reported sleep quality and
Copyright: © 2025 Author(s).
This is an Open-Access article the incidence of post-operative nausea and vomiting.
distributed under the terms of the Results: The study found that the TAP block provided superior post-operative
Creative Commons Attribution pain relief compared to preperitoneal infiltration with bupivacaine in patients
License, permitting distribution,
and reproduction in any medium, who underwent laparoscopic cholecystectomy. The TAP block group exhibited
provided the original work is significantly lower pain scores at 8 and 12 h postoperatively and experienced a
properly cited. delayed first request for rescue analgesia at 14.6 ± 2.52 h on average, compared with
Publisher’s Note: AccScience 7.1 ± 1.02 h in the preperitoneal group.
Publishing remains neutral with Conclusion: The findings establish that TAP block is a more effective analgesic
regard to jurisdictional claims in
published maps and institutional technique than preperitoneal infiltration with bupivacaine for managing
affiliations. post-operative pain in laparoscopic cholecystectomy. Patients receiving TAP block

Volume 9 Issue 3 (2025) 277 doi: 10.36922/EJMO025180164