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Global Health Econ Sustain                                     Prevalence and risk factors of childhood diarrhea



            2. Methods                                         (i)  Maternal factors: Maternal age and the mother’s
                                                                  education level were  included as  maternal  factors
            2.1. Data source and study participants               determining childhood diarrhea.
            The  study  utilized  secondary  data  extracted  from  the   (ii)  Children-related factors: Out of several child-related
            fifth round of the NFHS-5, conducted in India from    factors influencing  childhood  diarrhea, children’s
            2019– 2021 (International Institute for Population Science   age, birth order, and size were identified as important
            [IIPS]  &  International  Classification  of  Functioning   children-related factors affecting  diarrheal disease
            [ICF], 2019). The NFHS-5 is a nationally representative   among children aged under five.
            multistage sample survey designed to provide estimates   (iii) Household factors: The number of household
            of vital indicators at the district, state, and national levels.   members, electricity services, caste/tribe, religion,
            The primary objectives of NFHS-5 include gathering    and wealth quintile were recognized as some of the
            essential data on health and family welfare, as well as data   significant household factors influencing childhood
            on emerging issues such as fertility levels, infant and child   diarrheal disease.
            mortality, communicable and non-communicable diseases,   (iv)  Environmental factors: Type of toilet facility, floor
            and  other health and family welfare indicators across   material, wall material, roof material, altitude from sea
            various background characteristics. A  total of 724,115   level, and regional division were considered responsible
            women were interviewed from 636,699 households.       environmental factors for childhood diarrhea.
            Child-related information was provided by the mothers
            on behalf of their children. All living children under the   2.4. Statistical estimation
            age of five (N  = 232,920) who participated in NFHS-5   Before analyzing the dataset, a thorough check was
            were enrolled in this study. After applying inclusion and   conducted to identify and address missing  values and
            exclusion criteria, removing missing values, and filtering   irrelevant information. To adjust the clustered sampling
            out unnecessary responses such as “don’t know” for each   techniques employed in the surveys, a complex survey
            variable, the final study participants were 161,368 children   module was applied for all analyses, accounting for
            residing in rural areas and aged below 5 years. Mothers   primary sampling units, sample strata, and sample weight.
            were queried about their children’s diarrheal status in   Subsequently, descriptive statistics were carried out  to
            the 2 weeks before the survey. Information on diarrheal   understand the distribution of diarrheal disease among
            disease in under-five children was obtained through   children  under  5  years  of  age  across  socio-demographic
            a women’s questionnaire. The datasets from Indian   and environmental characteristics within the study
            Demographic Health Surveys (NFHS) are freely available,   sample. Moreover, the prevalence of diarrheal disease in
            and one can access the dataset from the online repository   rural areas among children under five years of age within
            of the Demographic and Health Survey Program website   2 weeks preceding the survey was estimated using selected
            through the following link: https://www.dhsprogram.  explanatory variables. Pearson’s chi-square test was applied
            com/data/available-datasets.cfm                    to  investigate the bivariate association between childhood
                                                               diarrhea  and  different  explanatory  variables.  Variables
            2.2. Outcome variables                             exhibiting significance at the 5% level were considered for the
            The study utilized responses on childhood (under the age   regression analysis. A binary logistic regression model was
            of five) diarrheal status in the 2 weeks preceding the survey   performed to calculate odds ratios, elucidating the association
            as a key outcome of interest. Childhood diarrheal disease,   between childhood diarrhea and various sociodemographic,
            which is referred to as the passage of three or more loose   economic, and living arrangement characteristics. The
            or liquid stools per day or a more frequent passage of liquid   significance level was set at 5% for the regression model. All
            stools than the normal state for an individual, was assessed.   statistical analyses were performed using STATA version 15.0
            This variable comprised two response categories: “yes”   (StataCorp LLC, Texas, United States).
            (indicating the presence of diarrhea) and “no” (indicating
            the absence of diarrhea), which were coded as “1” and “0,”   2.5. Spatial analysis
            respectively. The coding scheme for the outcome variable   In this study focusing on the spatial distribution of diarrhea
            was consistent with previous literature.           disease at the district level in India, data from both NFHS-4
                                                               and NFHS-5 have been utilized. First, all the district-
            2.3. Explanatory variables                         wise data were compiled using Microsoft Excel and then
            All the possible risk factors associated with childhood   exported into CSV-delimited format. Subsequently, the
            diarrheal disease were categorized as maternal, child-  CSV file was merged with the district shape file in Arc-GIS
            related, household, and environmental risk factors:  version 10.5 for further spatial analysis.


            Volume 2 Issue 2 (2024)                         3                        https://doi.org/10.36922/ghes.2048
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