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Global Health Economics and
Sustainability
Sustainable therapeutic Artemisia
annua L. as a plant with potential use in the treatment of Elfawal, M.A., Towler, M.J., Reich, N.G., Weathers, P.J., &
acanthamoebiasis. Parasitology Research, 115(4):1635-1639. Rich, S.M. (2015). Dried whole-plant Artemisia annua
https://doi.org/10.1007/s00436-016-4902-z. slows evolution of malaria drug resistance and overcomes
resistance to artemisinin. Proceedings of the National
Desrosiers, M.R., & Weathers, P.J. (2016). Effect of leaf digestion Academy of Sciences, 112(3):821-826.
and artemisinin solubility for use in oral consumption of
dried Artemisia annua leaves to treat malaria. Journal of https://doi.org/10.1073/pnas.1413127112
Ethnopharmacology, 190:313-318. Ellman, A. (2010). Cultivation of Artemisia annua in Africa and
Asia. Outlooks on Pest Management, 21(2):84-88.
https://doi.org/10.1016/j.jep.2016.06.041
Desrosiers, M.R., & Weathers, P.J. (2018). Artemisinin https://doi.org/10.1564/21apr08
permeability via Caco-2 cells increases after simulated Feeney, A.J., Goad, J.A., & Flaherty, G.T. (2024) Global perspective
digestion of Artemisia annua leaves. Journal of of the risks of falsified and counterfeit medicines: A critical
Ethnopharmacology, 210:254-259. review of the literature. Travel Medicine and Infectious
Disease, 61:102758.
https://doi.org/10.1016/j.jep.2017.08.038
Feng, J., Li, T., Yee, R., Yuan, Y., Bai, C., Cai, M., et al. (2019).
Desrosiers, M.R., Mittelman, A., & Weathers, P.J. (2020). Dried
leaf Artemisia annua improves bioavailability of artemisinin Stationary phase persister/biofilm microcolony of Borrelia
via cytochrome P450 inhibition and enhances artemisinin burgdorferi causes more severe disease in a mouse model of
efficacy downstream. Biomolecules, 10(2):254. Lyme arthritis: Implications for understanding persistence,
post-treatment lyme disease syndrome (PTLDS), and
https://doi.org/10.3390/biom10020254 treatment failure. Discovery Medicine, 27(148):125-138.
Devaraj, A., & Roelofson, M.F. (2015). Artemisia annua tea as a Feng, J., Shi, W., Zhang, S., & Zhang, Y. (2015). Identification of
rejuvenative therapy for HIV infected non ART AIDS patients. new compounds with high activity against stationary phase
World Journal Pharmaceutical Research, 4(6):941-946. Borrelia burgdorferi from the NCI compound collection.
Dhorda, M., Kaneko, A., Komatsu, R., Kc, A., Mshamu, S., Emerging Microbes and Infections, 4(1):e31.
Gesase, S., et al. (2024). Artemisinin-resistant malaria in https://doi.org/10.1038/emi.2015.31
Africa demands urgent action. Science, 385(6706):252-254.
Feng, J., Wang, T., Shi, W., Zhang, S., Sullivan, D., Auwaerter, P.G.,
https://doi.org/10.1126/science.adp5137 et al. (2014). Identification of novel activity against Borrelia
Diaz, K. (2023). Freight Container Farms: A Feasibility and burgdorferi persisters using an FDA approved drug library.
Sustainability Assessment. Champaign: University of Illinois Emerging Microbes and Infections, 3(1):1-8.
at Urbana-Champaign. Ferreira, J.F., Benedito, V.A., Sandhu, D., Marchese, J.A., &
Ding, F., Ma, T., Hao, M., Wang, Q., Chen, S., Wang, D., et al. Liu, S. (2018). Seasonal and differential sesquiterpene
(2020). Mapping worldwide environmental suitability for accumulation in Artemisia annua suggest selection based on
Artemisia annua L. Sustainability, 12(4):1309. both artemisinin and dihydroartemisinic acid may increase
artemisinin in planta. Frontiers in Plant Science, 9:1096.
https://doi.org/10.3390/su12041309
https://doi.org/10.3389/fpls.2018.01096
Dolivo, D., Weathers, P., & Dominko, T. (2021). Artemisinin and
artemisinin derivatives as anti-fibrotic therapeutics. Acta Ferreira, J.F., Peaden, P., & Keiser, J. (2011). In vitro trematocidal
Pharmaceutica Sinica B, 11(2):322-339. effects of crude alcoholic extracts of Artemisia annua,
A. absinthium, Asimina triloba, and Fumaria officinalis.
https://doi.org/10.1016/j.apsb.2020.09.001
Parasitology Research, 109(6):1585-1592.
Efferth, T. (2009). Artemisinin: A versatile weapon from traditional https://doi.org/10.1007/s00436-011-2418-0
Chinese medicine. In: Herbal Drugs: Ethnomedicine to
Modern Medicine. Germany: Springer, p.173-194. Ganfon, H., Yemoa, A., Assanhou, A.G., N’oueni, K., Amoussa, A.,
Morimont, L., et al. (2019). Pilot study of quality control of
Efferth, T. (2018). Beyond malaria: The inhibition of viruses Artemisia annua-based herbal medicine sold in Benin. Journal
by artemisinin-type compounds. Biotechnology Advances, of Pharmacognosy and Phytochemistry, 8(6):1817-1822.
36:1730-1737.
Ghaffarifar, F., Heydari, F.E., Dalimi, A., Hassan, Z.M.,
https://doi.org/10.1016/j.biotechadv.2018.01.001
Delavari, M., & Mikaeiloo, H. (2015). Evaluation of
Elfawal, M.A., Towler, M.J., Reich, N.G., Golenbock, D., apoptotic and antileishmanial activities of Artemisinin on
Weathers, P J., & Rich, S.M. (2012). Dried whole plant promastigotes and BALB/C mice infected with Leishmania
Artemisia annua as an antimalarial therapy. PLoS One, major. Iranian Journal of Parasitology, 10(2):258.
7(12):e52746.
Goel, R., Kumari, R., Singh, V., Kumari, R., Srivastava, S., &
https://doi.org/10.1371/journal.pone.0052746 Kumar, S. (2018). Perspectives of the Artemisia annua dry
Volume 3 Issue 3 (2025) 13 https://doi.org/10.36922/ghes.4927

