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Gene & Protein in Disease                                     NQO2 and dopamine toxicity versus detoxification



            29.  Asanuma M, Miyazaki I, Diaz-Corrales FJ, et al., 2004,   40.  King CD, Rios GR, Green MD, et al.,  2000, UDP-
               Quinone  formation as dopaminergic  neuron-specific   glucuronosyltransferases. Curr Drug Metab, 1: 143–161.
               oxidative stress in the pathogenesis of sporadic Parkinson’s      https://doi.org/10.2174/1389200003339171
               disease  and  neurotoxin-induced  parkinsonism.  Acta Med
               Okayama, 58: 221–233.                           41.  Ghosh C, Hossain M, Puvenna V, et al., 2013, Expression
                                                                  and functional relevance of UGT1A4 in a cohort of human
               https://doi.org/10.18926/AMO/32105                 drug-resistant epileptic brains. Epilepsia, 54: 1562–1570.
            30.  Miyazaki I, Asanuma M, 2008, Dopaminergic neuron-     https://doi.org/10.1111/epi.12318
               specific oxidative stress caused by dopamine itself. Acta Med
               Okayama, 62: 141–150.                           42.  Ouzzine M, Gulberti S, Ramalanjaona N, et al., 2014, The
                                                                  UDP-glucuronosyltransferases of the blood-brain barrier:
               https://doi.org/10.18926/AMO/30942                 Their role in drug metabolism and detoxication. Front Cell
            31.  Sulzer D, Zecca L, 2000, Intraneuronal dopamine-quinone   Neurosci, 8: 349.
               synthesis: A review. Neurotox Res, 1: 181–195.      https://doi.org/10.3389/fncel.2014.00349
               https://doi.org/10.1007/BF03033289              43.  Kutsuno Y, Hirashima R, Sakamoto M, et al.,  2015,
            32.  Hattoria N, Wanga M, Taka H, et al., 2009, Toxic effects of   Expression of UDP-glucuronosyltransferase 1 (UGT1) and
               dopamine metabolism in Parkinson’s disease. Parkinsonism   glucuronidation  activity  toward endogenous  substances
               Relat Disord, 15 Suppl 1: S35–S38.                 in humanized UGT1 mouse brain.  Drug Metab Dispos,
                                                                  43: 1071–1076.
               https://doi.org/10.1016/S1353-8020(09)70010-0
                                                                  https://doi.org/10.1124/dmd.115.063719
            33.  Boutin  JA,  1987,  Indirect  evidences  of  UDP-
               glucuronosyltransferase  heterogeneity:  how  can  it  help   44.  El-Bachá RS, Leclerc S, Netter P, et al., 2000, Glucuronidation
               purification? Drug Metab Rev, 18: 517–551.         of apomorphine. Life Sci, 67: 1735–1745.
               https://doi.org/10.3109/03602538708994131          https://doi.org/10.1016/s0024-3205(00)00764-5
            34.  Jackson MR, Fournel-Gigleux S, Harding D, et al.,  1988,   45.  Kilpatrick GJ, Smith TW, 2005, Morphine-6-glucuronide:
               Examination of the substrate specificity of cloned rat   Actions and mechanisms. Med Res Rev, 25: 521–544.
               kidney phenol UDP-glucuronyltransferase expressed in      https://doi.org/10.1002/med.20035
               COS-7 cells. Mol Pharmacol, 34: 638–642.
                                                               46.  Landsberg L, Berardino MB, Stoff J,  et al.,  1978, Further
            35.  Testa B, Krämer SD, 2007, The biochemistry of drug   studies on catechol uptake and metabolism in rat small
               metabolism an introduction: Part  2. Redox reactions and   bowel in vivo: (1) A quantitatively significant process with
               their enzymes. Chem Biodivers, 4: 257–405.         distinctive structural specifications; and (2) the formation
               https://doi.org/10.1002/cbdv.200790032             of a dopamine glucuronide reservoir after chronic l-dopa
                                                                  feeding. Biochem Pharmacol, 27: 1365–1371.
            36.  Renaud HJ, Cui JY, Khan M, et al., 2011, Tissue distribution
               and gender-divergent expression of 78 cytochrome P450      https://doi.org/10.1016/0006-2952(78)90121-1
               mRNAs in mice. Toxicol Sci, 124: 261–277.       47.  Alexander N, Yoneda S, Vlachakis ND, et al., 1984, Role of
               https://doi.org/10.1093/toxsci/kfr240              conjugation and red blood cells for inactivation of circulating
                                                                  catecholamines. Am J Physiol, 247: R203–R207.
            37.  Tourancheau A, Rouleau M, Guauque-Olarte S, et al., 2018,
               Quantitative profiling of the UGT transcriptome in human      https://doi.org/10.1152/ajpregu.1984.247.1.R203
               drug-metabolizing tissues. Pharmacogenomics J, 18: 251–261.   48.  Gaudin C, Ruget G, Selz F, et al., 1985, Free and conjugated

               https://doi.org/10.1038/tpj.2017.5                 catecholamines in digestive tissues of rats.  Life Sci,
                                                                  37: 1469–1474.
            38.  Suleman FG, Ghersi-Egea JF, Leininger-Muller B, et al., 1993,
               Uridine  diphosphate-glucuronosyltransferase  activities  in      https://doi.org/10.1016/0024-3205(85)90177-8
               rat brain microsomes. Neurosci Lett, 161: 219–222.   49.  Berndt TJ, MacDonald A, Walikonis R, et al., 1993, Excretion
               https://doi.org/10.1016/0304-3940(93)90298-y       of catecholamines and metabolites in response to increased
                                                                  dietary phosphate intake. J Lab Clin Med, 122: 80–84.
            39.  Leclerc S, Heydel JM, Amossé V, et al., 2002, Glucuronidation
               of odorant molecules in the rat olfactory system: Activity,   50.  Azoui R, Schneider J, Dong WX, et al., 1997, Red blood cells
               expression and age-linked modifications of UDP-    participate in the metabolic clearance of catecholamines in
               glucuronosyltransferase isoforms, UGT1A6 and UGT2A1,   the rat. Life Sci, 60: 357–367.
               and relation to mitral cell activity. Brain Res Mol Brain Res,      https://doi.org/10.1016/s0024-3205(96)00659-5
               107: 201–213.
                                                               51.  Itäaho K, Court MH, Uutela P, et al., 2009, Dopamine is a
               https://doi.org/10.1016/s0169-328x(02)00455-2      low-affinity and high-specificity substrate for the human


            Volume 2 Issue 1 (2023)                         7                         https://doi.org/10.36922/gpd.227
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