Page 54 - GPD-2-1

Gene & Protein in Disease NQO2 and dopamine toxicity versus detoxification

UDP-glucuronosyltransferase 1A10. Drug Metab Dispos, 62. Gould NL, Elkobi A, Edry E, et al., 2020, Muscarinic-
37: 768–775. dependent miR-182 and QR2 expression regulation in
the anterior insula enables novel taste learning. eNeuro, 7:
https://doi.org/10.1124/dmd.108.025692
ENEURO.0067-20.2020.
52. Uutela P, Karhu L, Piepponen P, et al., 2009, Discovery of https://doi.org/10.1523/ENEURO.0067-20.2020
dopamine glucuronide in rat and mouse brain microdialysis
samples using liquid chromatography tandem mass 63. Rappaport AN, Jacob E, Sharma V, et al., 2015, Expression
spectrometry. Anal Chem, 81: 427–434. of quinone reductase-2 in the cortex is a muscarinic
acetylcholine receptor-dependent memory consolidation
https://doi.org/10.1021/ac801846w constraint. J Neurosci, 35: 15568–15581.
53. Suominen T, Uutela P, Ketola RA, et al., 2013, Determination https://doi.org/10.1523/JNEUROSCI.1170-15.2015
of serotonin and dopamine metabolites in human brain
microdialysis and cerebrospinal fluid samples by UPLC-MS/ 64. Hashimoto T, Nakai M, 2011, Increased hippocampal
MS: Discovery of intact glucuronide and sulfate conjugates. quinone reductase 2 in Alzheimer’s disease. Neurosci Lett,
PLoS One, 8: e68007. 502: 10–12.
https://doi.org/10.1371/journal.pone.0068007 https://doi.org/10.1016/j.neulet.2011.07.008
54. Wang PC, Kuchel O, Buu NT, et al., 1983, Catecholamine 65. Janda E, Lascala A, Carresi C, et al., 2015, Parkinsonian
glucuronidation: An important metabolic pathway for toxin-induced oxidative stress inhibits basal autophagy in
dopamine in the rat. J Neurochem, 40: 1435–1440. astrocytes via NQO2/quinone oxidoreductase 2: Implications
for neuroprotection. Autophagy, 11: 1063–1080.
https://doi.org/10.1111/j.1471-4159.1983.tb13587.x
https://doi.org/10.1080/15548627.2015.1058683
55. Chhour M, Perio P, Gayon R, et al., 2021, Association
of NQO2 with UDP-glucuronosyltransferases reduces 66. Harada S, Fujii C, Hayashi A, et al., 2001, An association
menadione toxicity in neuroblastoma cells. Front Pharmacol, between idiopathic Parkinson’s disease and polymorphisms
of phase II detoxification enzymes: Glutathione S-transferase
12: 660641.
M1 and quinone oxidoreductase 1 and 2. Biochem Biophys
https://doi.org/10.3389/fphar.2021.660641 Res Commun, 288: 887–892.
56. Mailliet F, Ferry G, Vella F, et al., 2004, Organs from mice https://doi.org/10.1006/bbrc.2001.5868
deleted for NRH: quinone oxidoreductase 2 are deprived of 67. Wang W, Le WD, Pan T, et al., 2008, Association
the melatonin binding site MT3. FEBS Lett, 578: 116–120. of NRH: quinone oxidoreductase 2 gene promoter
https://doi.org/10.1016/j.febslet.2004.10.083 polymorphism with higher gene expression and increased
susceptibility to Parkinson’s disease. J Gerontol A Biol Sci
57. Fu Y, Buryanovskyy L, Zhang Z, 2008, Quinone reductase 2 is Med Sci, 63: 127–134.
a catechol quinone reductase. J Biol Chem, 283: 23829–23835.
https://doi.org/10.1093/gerona/63.2.127
https://doi.org/10.1074/jbc.M801371200
68. Harada S, Tachikawa H, Kawanishi Y, 2003, A possible
58. Ross D, Kepa JK, Winski SL, et al., 2000, NAD(P)H: quinone association between an insertion/deletion polymorphism
oxidoreductase 1 (NQO1): Chemoprotection, bioactivation, of the NQO2 gene and schizophrenia. Psychiatr Genet,
gene regulation and genetic polymorphisms. Chem Biol 13: 205–209.
Interact, 129: 77–97.
https://doi.org/10.1097/00041444-200312000-00003
https://doi.org/10.1016/s0009-2797(00)00199-x
69. Okada S, Farin FM, Stapleton P, et al., 2005, No associations
59. Ross D, Siegel D, 2004, NAD(P)H: quinone oxidoreductase 1 between Parkinson’s disease and polymorphisms of the
(NQO1, DT-diaphorase), functions and pharmacogenetics. quinone oxidoreductase (NQO1, NQO2) genes. Neurosci
Methods Enzymol, 382: 115–144. Lett, 375: 178–180.
https://doi.org/10.1016/S0076-6879(04)82008-1 https://doi.org/10.1016/j.neulet.2004.11.009
60. Goodman RP, Calvo SE, Mootha VK, 2018, Spatiotemporal 70. Wang W, Jaiswal AK, 2004, Sp3 repression of polymorphic
compartmentalization of hepatic NADH and NADPH human NRH: quinone oxidoreductase 2 gene promoter. Free
metabolism. J Biol Chem, 293: 7508–7516. Radic Biol Med, 37: 1231–1243.
https://doi.org/10.1074/jbc.TM117.000258 https://doi.org/10.1016/j.freeradbiomed.2004.06.042
61. Gould NL, Sharma V, Hleihil M, et al., 2020, Dopamine- 71. Benoit CE, Bastianetto S, Brouillette J, et al., 2010, Loss of
dependent QR2 pathway activation in CA1 interneurons quinone reductase 2 function selectively facilitates learning
enhances novel memory formation. J Neurosci, 40: 8698–8714. behaviors. J Neurosci, 30: 12690–12700.
https://doi.org/10.1523/JNEUROSCI.1243-20.2020 https://doi.org/10.1523/JNEUROSCI.2808-10.2010

Volume 2 Issue 1 (2023) 8 https://doi.org/10.36922/gpd.227