Page 21 - GPD-2-2
P. 21
Gene & Protein in Disease MOR in cancer
J Neurosci, 35(41): 13879–13888. 59. Erbs E, Faget L, Scherrer G, et al., 2015, A mu-delta opioid
receptor brain atlas reveals neuronal co-occurrence in
https://doi.org/10.1523/JNEUROSCI.2711-15.2015
subcortical networks. Brain Struct Funct, 220(2): 677–702.
48. Eisenstein TK, 2019, The role of opioid receptors in immune
system function. Front Immunol, 10: 2904. https://doi.org/10.1007/s00429-014-0717-9
60. Fields H, 2004, State-dependent opioid control of pain. Nat
https://doi.org/10.3389/fimmu.2019.02904
Rev Neurosci, 5(7): 565–575.
49. Giugliano D, Torella R, Lefèbvre PJ, et al., 1988, Opioid
peptides and metabolic regulation. Diabetologia, 31(1): https://doi.org/10.1038/nrn1431
3–15. 61. Scherrer G, Imamachi N, Cao YQ, et al., 2009, Dissociation
of the opioid receptor mechanisms that control mechanical
https://doi.org/10.1007/BF00279126
and heat pain. Cell, 137(6): 1148–1159.
50. Meng J, Yu H, Ma J, et al., 2013, Morphine induces bacterial
translocation in mice by compromising intestinal barrier https://doi.org/10.1016/j.cell.2009.04.019
function in a TLR-dependent manner. PLoS One, 89(1): 62. Pasternak GW, Pan YX, 2013, Mu opioids and their receptors:
e54040. Evolution of a concept. Pharmacol Rev, 65(4): 1257–1317.
https://doi.org/10.1371/journal.pone.0054040 https://doi.org/10.1124/pr.112.007138
51. Tuerxun H, Cui J, 2019, The dual effect of morphine on 63. Stein C, 2016, Opioid receptors. Annu Rev Med, 67: 433–451.
tumor development. Clin Transl Oncol, 21(6): 695–701.
https://doi.org/10.1146/annurev-med-062613-093100
https://doi.org/10.1007/s12094-018-1974-5
64. Spike RC, Puskár Z, Sakamoto H, et al., 2002, MOR-1-
52. Gupta K, Chen C, Lutty GA, et al., 2019, Morphine promotes immunoreactive neurons in the dorsal horn of the rat spinal
neovascularizing retinopathy in sickle transgeneic mice. cord: Evidence for nonsynaptic innervation by substance
Blood Adv, 3(7): 1073–1083. P-containing primary afferents and for selective activation by
noxious thermal stimuli. Eur J Neurosci, 15(8): 1306–1316.
https://doi.org/10.1182/bloodadvances.2018026898
https://doi.org/10.1046/j.1460-9568.2002.01969.x
53. Lu H, Zhang H, Weng ML, et al., 2021, Morphine promotes
tumorigenesis and cetuximab resistance via EGFR signaling 65. Wang D, Tawfik VL, Corder G, et al., 2018, Functional
activation in human colorectal cancer. J Cell Physiol, 236(6): divergence of Delta and Mu opioid receptor organization in
4445–4454. CNS pain circuits. Neuron, 98(1): 90–108.e5.
https://doi.org/10.1002/jcp.30161 https://doi.org/10.1016/j.neuron.2018.03.002
54. Zhang H, Sun M, Zhou D, et al., 2020, Increased mu-opioid 66. Gardon O, Faget L, Chu Sin Chung P, et al., 2014, Expression
receptor expression is associated with reduced disease-free of mu opioid receptor in dorsal diencephalic conduction
and overall survival in laryngeal squamous cell carcinoma. system: New insights for the medial habenula. Neuroscience,
Br J Anaesth, 125(5): 722–729. 277: 595–609.
https://doi.org/10.1016/j.bja.2020.07.051 https://doi.org/10.1016/j.neuroscience.2014.07.053
55. Zhang JJ, Song CG, Dai JM, et al., 2021, Inhibition of 67. Wager TD, Scott DJ, Zubieta JK, 2007, Placebo effects on
mu-opioid receptor suppresses proliferation of hepatocellular human mu-opioid activity during pain. Proc Natl Acad Sci
carcinoma cells via CD147-p53-MAPK cascade signaling U S A, 104(26): 11056–11061.
pathway. Am J Transl Res, 13(5): 3967–3986.
https://doi.org/10.1073/pnas.0702413104
56. Janku F, Johnson LK, Karp DD, et al., 2016, Treatment with 68. Zubieta JK, Bueller JA, Jackson LR, et al., 2005, Placebo
methylnaltrexone is associated with increased survival effects mediated by endogenous opioid activity on
in patients with advanced cancer. Ann Oncol, 27(11): mu-opioid receptors. J Neurosci, 25(34): 7754–7562.
2032–2038.
https://doi.org/10.1523/JNEUROSCI.0439-05.2005
https://doi.org/10.1093/annonc/mdw317
69. Cheng S, Guo M, Liu Z, et al., 2019, Morphine promotes
57. Kieffer BL, 1999, Opioids: First lessons from knockout mice. the angiogenesis of postoperative recurrent tumors and
Trends Pharmacol Sci, 20(1): 19–26.
metastasis of dormant breast cancer cells. Pharmacology,
https://doi.org10.1016/s0165-6147(98)01279-6 104(5–6): 276–286.
58. Corder G, Castro DC, Bruchas MR, et al., 2018, Endogenous https://doi.org/10.1159/000502107
and exogenous opioids in pain. Annu Rev Neurosci, 70. Song Z, Huang S, Yu H, et al., 2017, Synthesis and biological
41: 453–473.
evaluation of morpholine-substituted diphenylpyrimidine
https://doi.org/10.1146/annurev-neuro-080317-061522 derivatives (Mor-DPPYs) as potent EGFR T790M inhibitors
Volume 2 Issue 2 (2023) 15 https://doi.org/10.36922/gpd.282

