Page 14 - GPD-2-3

Gene & Protein in Disease Albumin (HSA) binding and health

of health. Evidence shows that raising HSA concentration 3. Levitt DG, Levitt MD, 2016, Human serum albumin
by successful infusion into the HPV will have the beneficial homeostasis: A new look at the roles of synthesis, catabolism,
consequences of stabilizing insulin and glucose levels, renal and gastrointestinal excretion, and the clinical value of
thereby reducing vulnerability to diabetes. There is ample serum albumin measurements. Int J Gen Med, 9: 229–255.
evidence that a healthy body should respond to an increase https://doi.org/10.2147/IJGM.S102819
of WBF by replacing all nutrients and blood cells in due 4. Johnson AS, Fatemi R, Winlow W, 2020, SARS-CoV-2
time, optimizing cellular nutrients and oncotic pressure as bound human serum albumin and systemic septic shock.
well as delivery of nutrients into cells. Such optimization Front Cardiovasc Med, 7: 153.
of the colloidal pressure of plasma will also optimize WBF, https://doi.org/10.3389/fcvm.2020.00153
bringing diastolic and systolic pressures to optimal and
ensuring optimal distribution of blood flow throughout 5. Johnson AS, Polese G, Johnson M, et al., 2022, Appropriate
the body. Clinical maintenance of WBF by HSA infusion to human serum albumin fluid therapy and the alleviation
the liver will stabilize HSA variability and diurnal changes, of COVID-19 vulnerabilities: An explanation of the HSA
lymphatic nutrient pump. COVID, 2: 1379–1395.
permitting the fine control of metabolites, including
glucose and ketones. https://doi.org/10.3390/covid2100099
6. Aldecoa C, Llau JV, Nuvials X, et al., 2020, Role of albumin
Acknowledgments in the preservation of endothelial glycocalyx integrity and
None. the microcirculation: A review. Ann Intensive Care, 10: 85.
https://doi.org/10.1186/s13613-020-00697-1
Funding
7. Capozzi ME, Coch RW, Koech J, et al., 2020, The limited role
None. of glucagon for ketogenesis during fasting or in response to
SGLT2 inhibition. Diabetes, 69(5): 882–892.
Conflict of interest
https://doi.org/10.2337/db19-1216
The authors declare no conflicts of interest.
8. Zavala-Barrios B, Cérbulo-Vázquez A, García-Espinosa M,
Author contributions et al., 2023, The Colloido-Osmotic Pressure as a useful
biomarker of fatal outcome in pregnant COVID-19 patients.
Conceptualization: Andrew S. Johnson medRxiv, 2023.06.29.23292050.
Writing – original draft: Andrew S. Johnson https://doi.org/10.1101/2023.06.29.23292050
Writing – review & editing: All authors
9. Casey JD, Brown RM, Semler MW, 2018, Resuscitation
All authors have read and agreed to the published version fluids. Curr Opin Crit Care, 24(6): 512–518.
of the manuscript. https://doi.org/10.1097/MCC.0000000000000551
Ethics approval and consent to participate 10. Laffel L, 1999, Ketone bodies: A review of physiology,
pathophysiology and application of monitoring to diabetes.
Not applicable. Diabetes Metab Res Rev, 15: 412–426.
Consent for publication https://doi.org/10.1002/(sici)1520-7560(199911/12)15:6<412:aid-
dmrr72>3.0.co;2-8
Not applicable.
11. Weaving G, Batstone GF, Jones RG, 2016, Age and sex
Availability of data variation in serum albumin concentration: An observational
study. Ann Clin Biochem, 53: 106–111.
Not applicable.
https://doi.org/10.1177/0004563215593561
References 12. Gom I, Fukushima H, Shiraki M, et al., 2007, Relationship
between serum albumin level and aging in community-
1. Johnson AS, Winlow W, 2022, The HSA lymphatic nutrient
pump (HSALNP) and its critical and central importance to dwelling self-supported elderly population. J Nutr Sci
health. EC Pharmacol Toxicol, 10(12): 32–34. Vitaminol (Tokyo), 53(1): 37–42.
https://doi.org/10.3177/jnsv.53.37
2. Johnson AS, Winlow W, 2021, COVID-19 vulnerabilities are
intensified by declining human serum albumin levels. Exp 13. Starling EH, 1896, On the absorption of fluids from the
Physiol, 107: 674–682. connective tissue spaces. J Physiol, 19: 312–326.
https://doi.org/10.1113/EP089703 https://doi.org/10.1113/jphysiol.1896.sp000596

Volume 2 Issue 3 (2023) 8 https://doi.org/10.36922/gpd.0328