Page 17 - GPD-2-3

Gene & Protein in Disease

REVIEW ARTICLE
Comprehensive prognostic signatures in thyroid

cancer: A summarized review for molecular
signatures construction strategies

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Xiaoyan Lu 1,2† , Yuanyuan Zhang 1,2† , Pei Yang , Minjun Yi , Luyao Wang ,
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Jing Chen , Han Wang , Mengke Li , Yufei Jiang , Bingbing Guo ,
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Wenyuan Lu , Shijia Li , Jiahao Chen , Yingying Lian , Xinyu Li ,
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Binbin Zhao , Xiaoqing Wang *, and Yang An *
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1 Department of Biochemistry and Molecular Biology, Cell Signal Transduction Laboratory, School of
Basic Medicine, Bioinformatics Center, Henan University, Kaifeng, 475004, China
2 Henan Provincial Engineering Center for Tumor Molecular Medicine, Kaifeng Key laboratory of cell
signal transduction, Kaifeng, 475004, China
Abstract
Thyroid carcinoma (TC) is one of the most common endocrine carcinomas with
an increasing rate of morbidity in recent decades. With a high risk of relapse and
metastasis occurring in TC patients, it is essential to identify potential prognostic
signatures for TC patients. Here, through a comprehensive review, we summarized 45
prognostic signatures for TC patients and concluded three main strategies for signature
† These authors contributed equally
to this work. establishment after an extensive investigation. In particular, these signatures were
classified according to different construction strategies, and the verification methods
*Corresponding authors:
Xiaoqing Wang were summarized. Besides, we found that 18 key genes were overrepresented
(wangxiaoqing@henu.edu.cn) in reported signatures. This review provides a comprehensive understanding,
Yang An systematic summary, and integrated analysis of current prognostic signatures of TC,
(anyang@henu.edu.cn)
which may help researchers to further understand cancer progression, construct
Citation: Lu X, Zhang Y, prognostic signatures of TC, and guide future clinical treatment.
Yang P, et al., 2023,
Comprehensive prognostic
signatures in thyroid cancer:
A summarized review for molecular Keywords: Thyroid cancer; Prognostic signatures; Survival outcome
signatures construction strategies.
Gene Protein Dis, 2(3): 1138.
https://doi.org/10.36922/gpd.1138
Received: June 26, 2023 1. Introduction
Accepted: August 16, 2023
Published Online: September 20, 2023 TC is considered one of the most common endocrine carcinomas with a considerably
high morbidity and mortality [1-3] . The average annual incidence of TC is more than 6%
Copyright: © 2023 Author(s).
[4]
This is an Open-Access article and has appreciably increased in recent decades . According to distinct origins and
distributed under the terms of the differentiation degree of TC cells, TC could be mainly divided into five pathological types:
Creative Commons Attribution
License, permitting distribution, and Papillary TC (PTC), follicular TC (FTC), poor-differentiated TC (PDTC), anaplastic TC
reproduction in any medium, which (ATC), and medullary TC (MTC) [5-8] . Among these, PTC and FTC were thought to be well-
provided that the original work is
properly cited. differentiated TC, the long-term survival rates of which are higher than 90%, and PTC is
considered the most common type of thyroid cancer [9,10] . In addition to the main five types
Publisher’s Note: AccScience [11]
Publishing remains neutral with of TC, a rare subtype of TC also exists, namely, spindle cell thyroid cancer (SCTC) .
regard to jurisdictional claims in
published maps and institutional Although most TC patients exhibited good prognosis, some patients still underwent
affiliations. high risks of cancer recurrence and distant metastasis [12-14] . At present, clinical treatments for

Volume 2 Issue 3 (2023) 1 https://doi.org/10.36922/gpd.1138